Police holding discussions to repatriating Iranian fishermen Police have announced that they are holding discussions on the matter of repatriating 14 Iranians on a fishing boat found in Maldivian seas. The boat was discovered near the island of Thimarafushi in Thaa Atoll on June 6, after having been lost at sea for two months. Police revealed that the boat and its crew are now in the island of Madifushi in Thaa Atoll. Likes ( 0 ) Dislikes ( 0 ) Iranian boat and suspects connected with heroin seizure released Police have released the Iranian vessel 8216Harmooz8217 and six Pakistani nationals who were arrested in connection with the 24kgs of heroin that was seized by the police last month. A police media official has confirmed the releases to local media but has declined to say why they had been released. 8216Hormooz8217 was seized after having carried the gs from Chahabar port in Iran and delivered it to the Maldivian fishing boat 8216Violet8217 30 nautical miles outside of Maldives EEZ. A total of eighteen officers were involved in the operation, with a police report describing the operation as a unique experience for all who took part in the record-breaking operation. Police have revealed that the money was transferred to the agents in Iran by a member of the Maldives Police Service who has subsequently been arrested in connection with the case. Four Maldivians, three Bangladeshis, and 11 Pakistanis were taken into custody in connection with the case. Local newspapers have reported that Abdulla Shaffath, who was arrested in connection with theArtur brothers case last year, was among the suspects taken into custody, although police have yet to confirm this.

Police Superintendent Mohamed Rasheed, head of the g Enforcement Department had previously told the media that the street value of the gs may have been up to MVR100 million (US6.5 million). Inaninterview with Minivan News in January, Home Minister Umar Naseer said that the main target of his ministry for the next five years would be curbing g-related crimes. Naseer said that he intended to give a high priority to enhancing the customs services in order to stop illegal gs and other contraband from being smuggled in to the country. He also said that the police intelligence department was being expanded. Leaving aside abusers and peddlers, the focus of this front will be on major wholesale g dealers. We will investigate how gs are brought into the country, find the contacts abroad, find ways to locate and take action against those involved even if they are abroad, he said. Likes ( 0 ) Dislikes ( 0 ) Police reveal details of record gs seizure Police have released detailed information of the special operation conducted to seize 24kgs of heroin smuggled into the Maldives using an Iranian vessel last month. A police officer implicated in the crime as well as the 11 Pakistani nationals on the Iranian vessel were among the 18 persons arrested in connection with the case. In the statement the police said that officers involved in the operation experienced things that they had never experienced before, and it was noted that the police officers aboard the speedboat were not carrying any weapons .

Police said that officers involved in the operation first followed two Maldivians who went to Villimal on March 4 where the Maldivian boat the Violet was prepared to set sail to meet an Iranian vessel which had journeyed from Chahabar, Iran. When the two Maldivians reached the boat docked in Villimal harbour, the boat captain and three expats working on board had already made all preparations to set sail towards North Ari atoll at around 3:30pm. Police officers were assigned to follow the Violet8217 on a gulf craft speedboat as itleft Mal with interceptedmunications revealing that the Maldivian boat planned to meet with the Iranian craft at 11pm that evening. The boat reached North Ari atoll at 6:15pm, stopping in the ocean between Rasdhoo and Mathiveri, before making its first trip to meet the Iranian vessel at 3:30am in the morning. According to police, the meeting point of the Iranian vessel and the 8216Violet8217 was 30 nautical miles north of North Ari atoll. The Maldivian boat travelled outside the EEZ of the Maldives in heavy rain and rough seas with the police speedboat following throughout. When the 8216Violet8217 reached the meeting point, its crew was informed that the Iranian ship was still 450 miles away from the meeting point, and that they will take 56 hours to get there.

The 8216Violet8217 subsequently returned to North Ari atoll. Police said the two men police originally followed subsequently returned to Mal, contacting their agent in Iran at 11:30pm to get details regarding the next attempted rendezvous. The following day, as the Violet refueled in preparation for its second trip to meet the Iranian vessel, the two Maldivians suspects attempted to transfer money to agents in Iran. Police have revealed that the money was transferred by a member of the Maldives Police Service who has subsequently been arrested in connection with the case. The next day 8216Violet8217 travelled on the same route as before, again stopping between Ukulhas and Mathiveri, before being contacted at 12:45am by the Iranian ship which explained that it was 200 miles from the meeting point. After receiving this news, the Maldivian boat travelled towards Baa Atoll 8211 outside Maldivian territorial waters 8211 and waited there until the Iranian vessel informed the crew that the gs were hidden inside a small dingy in the Iranian vessel. The following day (March 9) the Maldivian vessel reached the meeting point, but again had to wait for the Iranian vessel to get there the next morning. When the two boats met the the Maldivian boat tooka small dingy released by theIranian vessel and began its trip back to Mal late in the afternoon of March 10, the police statement said. Upon their arrival in Hulhumale that evening, all aboard 8216Violet8217 were arrested and the gs seized.

After collecting enough information to begin the operation, police assigned 16 officers to follow Violet: five intelligence officers were based in Mathiveri Island, a surveillance team consisting on seven officers was created. Eight intelligence officers were assigned as a ground analysis team, and a further five were assigned as ground technical team. Three intelligence officers were assigned as covert team and two others were used to tracemunications, the police statement revealed. Likes ( 0 ) Dislikes ( 0 ) Comment: Iranian people need Maldives leadership at the UN Dr Fatemeh Haghighatjoo is a former member of the Sixth Iranian Parliament.

A co-founder and chief executive officer of the Nonviolent Initiative for Democracy and a leading advocate for a civil, womens, and democratic rights in Iran. During its current session, the UN Human Rights Council has heard thelatest report from former Maldivian Foreign Minister and current UN Special Rapporteur on Human Rights for Iran Dr Ahmed Shaheed. The council is set to consider a resolution to extend Dr Shaheed8217s current mandate this Thursday (March 27). Eight months ago, Iranians overwhelmingly supported the moderate Mr Hassan Rouhani electing him president hoping that he could deliver on his promises to make meaningful human rights reforms. These include the release of political prisoners and prisoners of conscious, and specifically Irans most important political opposition leaders Mir Hossein Mousavi, Mehdi Karroubi and Ms. Zahra Rahnavard 8211 who have been placed under house arrest for three years without charges or even seeing a court. The internationalmunity weed Mr Rouhanis election for many of the same reasons. Yet today, Iran has seen little to no human rights changes. Speech remains strictly curtailed. Hundreds political prisoners languish behind bars.

Unfortunately, torture ismon while fair trials are rare. Indeed, Iran8217s leader and the judiciary have block any prospect of progress. Facing these internal challenges, the Iranian people need the internationalmunity to help prioritise human rights reforms in our country. The Maldives has played this role in recent years.

As one of 47 voting members of the United Nations Human Rights Council it voted to establish and renew a special rapporteur dedicated to monitoring the situation in Iran on three occasions. In fact, the Maldives sponsored these resolutions. In doing so the Maldives demonstrated why it was elected to the council. It established itself as leading member of the body and one of the few Muslim countries willing to defend human rights. As a Muslim myself, I know how vital it is that Muslim nations show theirmitment to human rights. This week, I hope Maldives demonstrates its leadership once again when the Iran vote is presented. To do otherwise would be to surrender its responsibilities at the Human Rights Council. The illegal detention of Mousavi, Karroubi, and Radnvard plays a key role in Iran and demonstrates the need for Maldives and the Council to act. These three people are no ordinary Iranians. Mousavi is a former Prime Minister of the Islamic Republic and Karroubi, a ranking cleric, is a former speaker of parliament.

Both were government-vetted candidates in the disputed 2009 presidential election, and Radnavar 8211 who is Mousavis wife 8211 is one of the most respected womens advocates in Iran and a former chancellor of Alzahra University. So, if these individuals can be stripped of their rights, held without legal justification, formal charges, or a trial in violation of Irans own constitution anyone can. After authorities stopped Mousavi, Karroubi, and Radnavar from joining a Feary 14, 2011 peaceful demonstration in support of the Arab Spring, hardline members of Irans parliament called for their deaths on the floor of parliament. For the last three years, the supreme leader has called them traitors and state and pro-government media have repeatedly used distorted religious rhetoric to demonise them. As a former member of parliament, Mr Karroubi was my boss, a friend and a mentor. Karroubi is a kind, caring and social person. Human interaction is at the core of his personality.

And for three years he has been cut off from the outside world, from visits with others with the rare exception of a few allowed visits from his wife and children. When I was a member of parliament, Karroubi frequently visited with the families of political prisoners and learned of their plight. He advocated on their behalf and in at least two instances, his support for prisoners sentenced to death led to their executions being stayed. Mousavi and Radnvard were no different 8211mitting themselves in defense of the rights of Iranian people and for this paid the price. And it isnt just Mousavi, Karroubi, and Radnvard suffering in Iran. This month, 23 prisoners of conscience wrote an open letter calling for an urgent visit to Iran by international human rights bodies and Dr Ahmed Shaheed, the appointed UN Special Rapporteur on the Situation of Human Rights in Iran, to investigate the systematic violations taking place inside prisons. As a former member of parliament, I understand the Islamic Republic. I know the only way well see change in Iran is when the world stands with the people of Iran and loudly raises its concern. The Maldives cannot ignore what is happening in Iran.

This week, it must join the Human Rights Council and adopt a resolution renewing the mandate on human rights in Iran. The Maldives should also call for the release of Mousavi, Karroubi, and Rahnavard and other political prisoners and prisoners of conscience in Iran. For progress to be made, UN member states must stand together and tell Irans supreme leader that Iran must improve its dismal human rights record. Likes ( 0 ) Dislikes ( 0 ) Comment: Maldives should honor its history by supporting the rights of the Iranian people In theing days, the United Nations General Assembly will adopt a human rights resolution passed last month by its humanitarianmittee aimed at improving the lives of Irans citizens. The human rights conditions of Iranians have been abysmal for three decades now. This includes entrenched political repression, state-sanctioned gender and religious discrimination, and institutionalised violence and torture of government critics.

Today, nearly a thousand political prisoners and prisoners of conscience languish in Iranian prisons due to the exercise of their guaranteed rights to expression, conscience, and religion. While newly elected President Hassan Rouhani has provided hope to Iranians who voted him in on a platform of citizens rights, limits to presidential power are already undercutting his administrations ability to usher in the human rights reforms he promised during his campaign for president. Policymaking in Iran also rests with unelected officials, so for Rouhani to advance his reform agenda, support from Irans Supreme Leader is necessary. What the Iranian people desperately need, therefore, and what President Rouhani can benefit from, is sustained and elevated attention to their situation. This will help Irans entire leadership understand that episodic or cosmetic steps will not be accepted as a substitute for genuine, broad-based democratic human rights reforms.

Yet, when the vote on this issue was called at the United Nations in November, the Maldives seat was empty. This is all the more astonishing since the Maldives, itself, recently emerged from authoritarianism following its first multi-party elections in 2008. Meanwhile, the Maldives asked the UN General Assembly not once, but twice, to be elected to the Human Rights Council. It was the UN that called attention to a lack of gender equality in the Maldives judicial appointments, which helped the Maldives end gender discrimination within the judiciary, leading to the appointments ofthe countrys first-ever female judges. In Iran, female judges were unjustly removed from the bench after the 1979 revolution. They should be returned to their rightful posts. Remembering the role of the internationalmunity It was just eight years ago when in 2005, the UN Special Rapporteurs on freedom of expression, freedom of religion or belief, and human rights defenders sent an urgent appeal to the government of the Maldives concerning the now-defunct Supreme Council for Islamic Affairs declared ban on the possession of the Universal Declaration of Human Rights (UDHR). The government responded within a week affirming its support for the UDHR and explaining that the Councils statement was not legally binding.

Moreover, the Deputy Minister of Foreign Affairs responded a month later to confirm the initial response and to inform the UN experts that the government notified the Council to desist from such pronouncements without prior consultation. For these reasons, and more, the Maldivian people understand firsthand the vital role played by the internationalmunity in assisting nations to make human rights progress. The Iranian people deserve the same support from the internationalmunity. They certainly deserve the backing of the Maldivian people who have faced similar challenges and benefitted from the UNs attention.

The Iran human rights resolution focuses on many critical issues, such as the lack of freedom of expression and assembly in the country 8211 as well as the need to release the hundreds of human rights defenders, activists, journalists, and opposition members in prison. It catalogues how women and religious minorities continue to face severe discrimination in law and practice, sometimes amounting to persecution. It discusses the countrys exorbitant execution rate, the highest per capita in the world. It requests Iran to end the practice of juvenile executions, public executions and other executions carried out in the absence of respect for internationally recognized safeguards, as well as to end inhumane and degrading forms of punishment, including amputation. Despite President Rouhanis election, more than 254 hangings have been carried out by Irans judiciary since his inauguration in August.

The government has surpassed last years record by executing 529 people as of the end of November. Finally, the resolution calls on Iran to cooperate with UN human rights special procedures, including the mandate of the UN Special Rapporteur on the situation of human rights in Iran, who has not been allowed to visit the country since 2005. The Maldives has the ability again this week to be present when the vote on the human rights of the Iranian people is called at the UN General Assembly. It has another opportunity to honor its own painful and inspirational history, and to honor the hundreds of prisoners of conscience in Iran who continue to fight for their freedom and for their human dignity. The Maldives should vote yes for its own people and for the people of Iran. Dokhi Fassihian is an international human rights expert. Since 2003, she has led three non-governmentalanizations working in the areas of human rights, democracy, and Iranian affairs Allment pieces are the sole view of the author and do not reflect the editorial policy of Minivan News. If you would like to write an opinion piece, please send proposals to editorialminivannewsarchive Likes ( 0 ) Dislikes ( 0 ) Shaheed more 8220actor than rapporteur8221: Iran8217s human rights chief Iranian officials have accused former Maldivian foreign minister Dr Ahmed Shaheed, subsequently appointed UN Special Rapporteur on Iran, of failing to perform his duties adequately.

The Secretary General of Irans High Council for Human Rights labelled Dr Shaheed more of an actor than a rapporteur, suggesting that he had been acting like an inspector rather than a rapporteur according to the Tehran Times . Mohammad Javad Larijani at the same time rejected Shaheeds requests to visit the Islamic republic, stating: I believe that the request is not serious. I believe that in view of the measures taken by Ahmed Shaheed and the show of interviews launched by him, he is more of an actor than a rapporteur, he added. Dr Shaheed was appointed Special Rapporteur on Human Rights in Iran in 2011 8211 the first time a Maldivian has held such a position.

The decision to establish a Special Rapporteur on Iran was made in 2011 after the deterioration of human rights in the country following the 2009 election. The mandate for the position includes investigating human rights abuses and undertaking country visits in order to report back to the General Assembly. The Tehran Times also quoted Irans Foreign Ministry Spokesman, who also attacked Dr Shaheed. He has not acted fairly and has played the role of the opposition, and his measures have been outside the purview of a UN rapporteur, the paper quoted Abbas Araqchi as saying. The spokesman is reported to have said that Iran has no intention of allowing Shaheed into the country until his approach is modified.

Shaheed is scheduled to report his recent findings to the General Assembly in October. In his last report in March, he informed the UN Human Rights Council that Irans human rights violations had increased in the past two years. In a list of rmendations, he urged Iran to extend its full cooperation to the country mandate-holder by engaging in a substantive and consctive dialogue and facilitating a visit the country. Irans official response to this report described it as biased and as disregarding the realities on the ground8221 and 8220principles of transparency, fairness and impartiality. Speaking with the Canadian media last month, Dr Shaheed had expressed hope that the new administration of President Hasan Rohani would result in greater opportunities for dialogue. Skepticism borne out of previous experience should not make us blind to opportunities, he told theNew Canadian Media website. Shaheeds chief critic, Larijani, made headlines last year when he reportedly described homosexuality as a disease.

Likes ( 0 ) Dislikes ( 0 ) Ahmadinejad sends independence day congratulations to President Waheed President Mahmoud Ahmadinejad of Iran has congratulated President Mohamed Waheed of the Maldives for the occasion of the country8217s Independence Day, according to the Islamic Republic News Agency (IRNA). 8220President Mahmoud Ahmadinejad on Monday congratulated anniversary of Maldives Independence Day to his Maldivian Counterpart President Huhammad Hassan Vahid,8221 IRNA reported. Ahmadinejadexpressed hoped 8220that the relations between the Islamic Republic of Iran and the Republic of Maldives would expandprehensively more than ever before,8221 the agency added. 8220The IRI president meanwhile in his message hoped for the establishment of peace and security throughout the world, and prayed to God for good health and evermore success of President Muhammad Hassan Vahid, as well as prosperity and wellbeing of the Muslim Maldivian government and nation.8221 Likes ( 0 ) Dislikes ( 0 ) President Waheed discusses expanding Iranian relations President Dr Mohamed Waheed Hassan hasmitted to strengthen relations with Iran in a number of areas such as education and energy, the country8217s state media has reported. The staten Fars News Agency has reported that President Waheed had shown willingness to expand ties between the two nations during a meeting with Iranian Deputy Foreign Minister Abbas Araqchi in Male8217 last week. Thements were as Iranian President Dr Mahmoud Ahmadinejad invited Dr Waheed to attend the 16th Non Aligned Movement Summit in Iran between August 30 to 31. The invitation was delivered personally by Deputy Foreign Minister Abbas Araqchi at meeting at the President8217s Office.

Discussions were also held on the potential for investment and higher education opportunities from Iran. Likes ( 0 ) Dislikes ( 0 ) Iranian Ambassador Nabi Hassani-Pour meets President Waheed President Dr Mohamed Waheed Hassan has met with the Iranian Ambassador of Iran accredited to the Maldives, Mohammed Nabi Hassani-Pour. At a meeting at the President8217s Office in Male8217 yesterday, Dr Waheed discussed the current state of bilateral relations with Iran, as well as means to further strengthen cooperation with the Maldives. The ambassador was also thanked for the ongoing support provided by Iran in relation to the country8217s economic situation, according to the President8217s Office website.

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The natural choice in urinary calculi and UTI Anti-lithiatic and lithotriptic: Cystone has potent anti-lithiatic (prevents the formation of kidney stones) and lithotriptic (dissolves kidney stones) properties. It prevents the accumulation, deposition and supersaturation of calculogenic chemicals like oxalic acid and calcium hydroxyproline in urine. This action inhibits the formation of kidney stones. Its lithotriptic property dissolves mucin, which binds the stone particles together. Cystone is also a diuretic that flushes out small stones from the kidneys.

bats urinary tract infections and symptoms: Cystone normalizes urinary pH and alleviates burning during urination. Its antimicrobial property bats mon urinary pathogens. Its demulcent and anti-inflammatory properties are beneficial in soothing an irritated bladder. For the prevention and treatment of adult and pediatric urolithiasis (kidney stone formation), including calcium oxalate stones, calcium and phosphate stones and uric acid and urate bladder stonesCrystalluria (presence of crystals in urine)Prevention of post lithotripsy (removal of kidney stones with shockwaves) recurrence of stonesAs an adjuvant in chronic UTI, nonspecific urethritis (irritation or swelling of the urethra) including dysuria (painful urination or blood present in urine), burning micturition (urination) and hyperuricemia (gout) Small Caltrops (Gokshura) is helpful the management of uro-genital diseases like kidney stones, bladder infection and other urinary tract infections. It helps promote general urinary tract health by eliminating dysuria (painful urination or blood present in urine) and crystalluria. Small Caltrops prevents the deposition, accumulation and supersaturation of calculogenic chemicals in urine.

It is a potent antimicrobial agent. Pasanabheda (Saxifraga Ligulata) possesses diuretic, demulcent and antimicrobial properties. Due to a high content of mucilage, which renders the herb its demulcent property, Pasanabheda soothes and protects irritated or inflamed internal tissue. As a diuretic, the herb helps to flush out small stones and gravel along with urine. Shilapushpa (Didymocarpus pedicellata) is known for its antilithiatic property, which prevents the formation of urinary stones. As a lithotriptic, Shilapushpa helps dissolve kidney stones. The herb is also known for its antimicrobial properties.

Please consult your physician to prescribe the dosage that best suits the condition. Available as tablet and syrup. Cystone review Cystone . an herbal formula which is posed of ginger, shilapuspha, pasanabheda, Indian madder, umbrellas edge, prickly chaff flower, sedge, purple fleabeane, lime silicate calx and mineral pitch, aids in keeping the urinary tract healthy. It also maintains the position of the urine and the integrity of the mucus in the body. By acting as a diuretic in order to help relieve temporary water, it is also responsible for health water management in the body. Shilapuspha, one of the ingredients of this Cystone, has been shown to be effective in keeping the urinary tract healthy.

Pasanavheda is used as a diuretic that would maintain the crystal-colloid balance that maintains the amount of calcium salts in a persons blood. promoting optimum urinary function. The rough chaff tree is another wonder ingredient because it is known for its effectiveness as a diuretic and cardiac tonic. The Indian Madder purifies the blood and regulates the immunity system. It may also have some antioxidant properties. The Umbrellas Eagle has also been proven to promote a healthy gentio-urinary system. Lastly, the sedge has been known for its ability to increase the bodys immune resistance and regulate the excretion of urine.

Being the bination of these fantastic ingredients, Cystone is taken in in order to prevent and treat urinary stones. For people who have already undergone surgery in order to remove urinary stones, this formula can be used to stop it from recurring. Another benefit of drinking this formula is its ability to treat burning urination and stop the recurrence of urine tract infection. Cystone has anti-bacterial and anti-inflammatory properties that can help stop the recurrence of urinary tract infection. Also, because it can normalize the acidic urine, it can relieve burning urination. Because it can also lessen the concentration of the substances that can cause the formation of stones in the urinary tract and aid in expelling them from the body, this wonder drug can also stop the recurrence of urinary tract stones. For people who need to undergo treatment because of urinary tract stones, Cystone can help them by acting on mucin, the gummy substance which binds the small particles together, breaking the stones inside the urinary tract.

By taking one to two capsules twice a day for several weeks, this natural product can produce progressive and long-lasting results. Patients who have kidney. liver and heart impairment should take extra precautions when taking this drug. Because it is natural, Cystone does not produce any side effects as long as the right amount is taken. Neither d oes it have any significant drug interactions. No contraindications for the use of Cystone have been reported. Cystones effectiveness as a means of maintaining urinary health was proven in a study that involved a controlled trial of one hundred cases. According to the results that were published in the Current Medical Practice in May 1982, Cystone performed very well in 76 of the cases.

Even after prolonging the use for six months, no side effects were found. Kidney stones ndash they really pain severely The pain that kidney stones fabricate is as much as getting stabbed in the flanks with a sharp knife. Even worst, the pain is felt as if someone has perverted that sharp edge knife. The process could be repeated for a few more times without giving any announcement to the sufferer. The reason why renal calculi (medical term for kidney stones) produce so concentrated pain is because they have a razor-sharp, jagged edges due to an obvious reason that they are subsequent to all stones. When these stones try to get passed through the urethra, they cause severe pain, and can hurt all the organs they go through. There are many ways to lessen the pain cause by renal calculi such as using a natural product like Cystone from the makers of Liv.52, the Himalaya Health Care pany. The manufactured goods have natural herbal extracts as its potent ingredient those are said to smooth the sharp edges of the stones and ultimately dissolving them to a dust like tiny particle.

Stone in attendance in the urinary tract might cause severe tenderness bleeding and can also get in the way the urine flow, or can also produce renal infection. Cystone used as a kidney stone behavior can stop the process of urolithiasis (medical term for stone formation). According to estimation, every year, 1 out of 1000 adults in the United States gets hospitalized due to stones where on earth in their urinary tract. Stones strength form when the urine is very saturated with different salts folks can form stones or basically due to the urine that lacks the normal inhibitors required to stop the understanding of the calculi. position of the renal calculi About 80 of the stones are made up of building block calcium. However, renal calculi can also be formed due to various other elements/machinery such as uric acid, cosine, and straiten. Straiten stone is a mixture of Mg (magnesium), NH4, and phosphate and this is acknowledged as infection stone since it occurs generally in urine with some infection. Stones are different in size and shape from being too tiny to be seen with the microscope alone to one inch or supplementary in diameter that can be seen with naked eyes. Cystone Ingredients: Shilapuspha (Didymocarpus pedicellata) 130mg Pasanabheda (Saxifraga ligulata Syn. Bergenia ligulata / ciliata) 98mg Manjishtha (Rubia cordifolia) 32mg Nagarmusta (Cyperus scariosus) 32mg Apamarga (Achyranthes aspera) 32mg Gojiha (Onosma bracteatum) 32mg Sahadevi (Vernonia cinerea) 32mg Shilajeet (Purified) 26mg Hajrul yahood bhasma 32mg Kidney stone formation and role of Cystone The kidneys are very awful organs and the task they perform is particularly important one. Kidneys are responsible to cleanse the bodies of the potentially deadly toxic substance that are formed in the body on a daily basis.

They ca not do this tremendously tough job without a favor from us undoubtedly. When the person pumps up by way of more soda and than water, or more chocolate and not fruits, they debilitate the kidneys and make a fair probability to have excruciating renal calculi. Everything in the body is posed of a organization that depends upon proper functioning and balance. Urine is the fluid that kidneys send out out of the body is no different. When the urine contains calcium or uric acid in excess amount than the kidneys can break them down, or kidneys are short of the ponents that they require to avert the crystal-forming contents like calcium to get stick together then such crystals turn in stones/calculi. The size of these calculi possibly will be as tiny as a grain of sand or it could be as huge as sparrowrsquos egg. Regular consumption of Cystone as a therapy for kidney stone elimination helps in preventing those troublesome episodes when you are awakened in the core of the night because of an extensive pain felt below the ribs. The pain is so severe with the intention of you may bend forward to heal it naturally. Though you have tried drinking plenty of hose down on a daily basis, it might not have helped you the way you wanted. Cystone is a powerful herbal pill that can break downstairs the stone and gradually even melt curing the renal calculi.

Actions of Cystone Cystone can diminish renal calculi pain It can also flush out grate and cleanse the urinary tract Cystone can dissolve calculi by temporary on their chemical position Regular intake of Cystone can stop inflammation and urinary infections caused by movement of existing calculi It can also prevent calculi from form in the future Cystone ndash herbal way to get rid of kidney stones Cystone is a revolutionary, non-prescription natural product that contains ingredient those have been used for kidney stones since years. Regular convention of Cystone is said to flush kidney stones out of the body and also stop new ones from form. With the betterment and advancement in medical science, there are lots of researches those have helped scientists to make out the biochemical cause of renal calculi. Based on that new result, researchers were capable to isolated potential chemical extracts from herbs those have been said as kidney friendly plants. Using this indispensable material, Cystone is prepared to reverse the element process of kidney stone formation and also to breakdown them, if any. The active ingredient present in Cystone can help supporting the four most important factors of kidney stone removal mentioned underneath: 1. Cystone can disintegrate renal calculi and decrease the intensity of soreness. 2. Regular consumption of Cystone can flush out irritate from the body through urination. 3. Many health care providers judge that Cystone, along with its stone breaking properties, can also prevent urinary tract infections.

4. Cystone can also be in use as prophylactic herbal supplement to prevent the formation of renal calculi. Kidney stones are the result of gathering of metabolic wastes for months together. The wastage that had to be eliminated through the urine is store and then formed renal calculi. Such kind of accumulation might happen when the chemicals and pH atmosphere of the kidneys just get out of its track. Even the smallest calculus is wide enough to get unavailable in urinary tract and can cause a severe damage.

The real danger from renal calculus lies in its changeable potential to hurt the organ. Product Ingridients: Apamarga (Achyranthes aspera) Gojiha (Onosma bracteatum) Manjishtha (Rubia cordifolia) Nagarmusta (Cyperus scariosus) Pasanabheda (Saxifraga ligulata) Sahadevi (Vernonia cinerea) Shilajeet (Purified) Shilapuspha (Didymocarpus pedicellata) Other names used: Therapeutic actions: Cystone is a herbal medication that exerts diuretic, spasmolytic, litholytic, antibacterial and anti-inflammatory action. The medication regulates crystalloid-colloid balance in dismetabolic nephropahty, reduces the amount of chemicals responsible for production of kidney stones(calcium, oxalic acid, hydroxyproline). Cystone increases the level of microelements that inhibit the process of kidney stones production(sodium, magnesium, potassium). By acting on mucin the preparation contributes to stones desintegration.

Cystone stimulates diuresis and relaxes the smooth muscles of the urinary tract. Cystone is effective in elimination of oxalate and phosphate salts, uric acid from the urinary tract. Cystone exerts bacteriostatic and bactericidal action, especially against Klebsiella spp. Pseudomonas aeruginosa, Escherichia coli and other gram-negative bacteria. Litolytic effect of the preparation does not depend on urinary PH levels. Cystone is indicated in the following conditions: Prophylaxis and treatment of urolithiasis in children and adults Crystalluria Urinary tract infections Gout Contraindications and Cautions: Cystone should not be used in known hypersensitivity to any of the medication active ingredients Talk with your health care provider prior to taking Cystone if you are pregnant or breastfeeding Do not use Cystone in acute pain in the urinary tract. There are possible side-effects associated with this medicine that can affect individuals in different ways.

If a side effect is stated here, that does not necessarily mean the fact that all people using Cystone will experience it or any other. In rare cases skin allergic reactions and acute pain in the urinary tract are possible. If you experience any of these side effects during treatment stop taking Cystone immediately. The side effects listed above may not include all of the side effects reported by the drugs manufacturer. For more information about any other possible risks associated with Cystone, please read the information provided with Cystone or consult your doctor or pharmacist. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Cystone. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the bination is safe.

Cystone may enhance the effects of antibiotics used in the treatment of urinary tract infections. Cystone may interact with medicines used to treat kidney stones(urolithiasis). DO NOT SHARE Cystone with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials. Himalaya Cystone Benefits of Cystone: Urinary Tract Health, Kidney Health Cystone is an ayurvedic formulation of herbs and minerals. Cystone naturally promotes a healthy urinary tract and helps maintain normal urine position and mucosal integrity.

It is a natural aid in maintaining healthy water management and relieves temporary water - weight gain. How does Cystone work What are the benefits of Cystone Cystone helps to flush the urinary tract safely and gently Cystone maintains normal urine position Cystone promotes normal kidney health Cystone promotes normal urinary tract health Cystone soothes the urinary tract using systemic flushing Cystone supports normal equilibrium of pH (acidity or alkaline) in the bladder Helps in supporting the immune system Helps to prevent urinary stones What are the ingredients in Cystone Ingredients (Per Tablet):Shilapuspha (Didymocarpus pedicellata) 130mg Pasanabheda (Saxifraga ligulata Syn. Bergenia ligulata / ciliata) 98mg Indian madder / Manjishtha (Rubia cordifolia) 32mg Umbrellas edge / Nagarmusta (Cyperus scariosus) 32mg Prickly chaff flower / Apamarga (Achyranthes aspera) 32mg Sedge / Gojiha (Onosma bracteatum) 32mg Purple fleabane / Sahadevi (Vernonia Cinerea) 32mg Lime silicate calx / Hajrul yahood Bhasma / Badrashma bhasma 32mg Shilajit 26mg Cystone Ingredients in Ayurveda In India several indigenous herbs for maintaining urinary tract health have been in vogue since ancient times Charak (600 BC) and Sushruta (1000 BC). These herbs include Didymocarpus pedicellata (Patharphor), Pasanabheda, Dolichos biflorus (Kulath), Rubia cordifolia (Manjit), Crataeva nurvala (Varuna) and Tamarindus indica (Tamarind). Cystone, manufactured by The Himalaya Drug Co. is a formulation of such herbs. How do the herbs and minerals in Cystone promote urinary tract health Didymocarpus pedicellata also known as Shilapushpa which literally means Stone flower is widely used in traditional Indian medicine for renal issues. In research studies the herb extract was shown to provide antioxidant activity and protect against renal oxidation.

Saxifraga ligulata also known as Pasana bheda which literally means that which breaks stones has been used in ayurveda to maintain renal health and for protecting against vesical calculi. It is known in Ayurveda for its ability to dissolve stones. Rubia cordifolia or Manjistha posseses detoxifying and diuretic properties that help to maintain the health of the urinary tract Umbrellas edge or Nagarmusta is used in traditional Ayurvedic medicine to reduce swelling and is a detoxifying agent that cleanses the kidneys, pancreas, liver, spleen and uterus Prickly chaff flower or Apamarga helps to break up calculi, cleanse the blood and also helps reduce swelling of internal organs. It is also anti-pyretic in nature Sedge or Gojiha is considered beneficial for the kidneys, prevention of kidney stones and pulmonary system Purple fleabane or Sahadevi is helpful in reducing bladder spasms, purifiying blood and normalizing urinary flow Hajrul yahood bhasma is a fossilized mineral powder that contains silicate of lime. It has diuretic and lithontriptic properties and helps normal flushing of urine. Shilajit helps in promoting a smooth urine flow. What are the directions for taking Cystone Take 2 tablets twice daily with meals.

May be increased to 2 tablets three times daily, if required. Allow several weeks for benefits. The use of natural products provides progressive but long-lasting results. Does Cystone have any side effects Does Cystone have any contraindications and drug interactions Special precautions Special precautions are to be exercised in patients with kidney, liver and heart impairment who are taking prescription medicines. Since Cystone is also meant to help kidney and liver functions, you should inform your physician as medicine dosage may need to be monitored Side effects Cystone does not produce any side effects, if taken as per the prescribed dosage. Drug intractions No clinically or biochemically significant drug interactions have been reported with the use of Cystone.

Cystone from Himalaya Herbals Cystone is a product from the renowned Himalaya Herbals brand endorsed by over 250,000 doctors worldwide and used by customers in over 60 countries. Himalaya Herbals products have been researched clinically and standardized to guarantee bioequivalence. Bioequivalence refers to ensuring that the product on the market is equivalent to the one on which clinical trials were successfully conducted. Himalaya Herbal Healthcare uses chromatographic fingerprinting, one of the most sophisticated standardization techniques, to ensure consistent quality and performance Cystone Research and Clinical Studies Cystone has been subjected to various clinical studies to establish its benefits for the urinary tract and kidneys. Various research studies on cystone have been documented in medical journals. Kidney stones are a mon problem for which inadequate prevention exists.

We recruited ten recurrent kidney stone formers with documented calcium oxalate stones into a two phased study to assess safety and effectiveness of Cystonex000ae, an herbal treatment for prevention of kidney stones. The first phase was a randomized double-blinded 12 week cross over study assessing the effect of Cystonex000ae vs. placebo on urinary supersaturation. The second phase was an open label one year study of Cystonex000ae to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. Results revealed no statistically significant effect of Cystonex000ae on urinary position short (6 weeks) or long (52 weeks) term. Average renal stone burden increased rather than decreased on Cystonex000ae. Therefore, this study does not support the efficacy of Cystonex000ae to treat calcium oxalate stone formers. Future studies will be needed to assess effects on stone passage, or on other stone types. Keywords: puterized Tomography, Cystonex000ae, herb, Kidney Calculi, supersaturation, nephrolithiasis, quantitative CT Introduction Kidney stones are a global affliction causing a great deal of morbidity and economic loss. 1 The prevalence of nephrolithiasis increases as societies bee industrialized. 2 ,3 ,4 Therefore, the worldwide burden is likely to increase in future years.

A method to prevent kidney stones would be an obvious benefit. Existing treatments with evidence that supports their long term efficacy to prevent calcium oxalate kidney stones include dietary and lifestyle changes, as well as chronic use of one of three medications (thiazides, potassium citrate, and allopurinol). No new treatments have been established in decades, and these that are available have inherent problems related to patient pliance, cost, effectiveness and side effects. Therefore, a preventive treatment that would be easy to take, low in cost, safe and effective would be highly desirable.

Cystonex000ae tablets are an Ayurvedic treatment for stones, traditionally practiced in India. Many studies and long experience attest to the safety of this pound. It is also claimed that Cystonex000ae decreases urinary supersaturation or micropulverizes and expels kidney stones, but existing studies have been limited by small patient numbers, weak methodology, and poor study design including lack of proper controls. Therefore, in this study we rigorously evaluated the ability of Cystonex000ae to decrease urine supersaturation and to prevent new stone formation and growth of existing stones via a short-term randomized, placebo-controlled, double-blinded, cross over study (to evaluate effects on urinary chemistries), followed by an open label extension (to evaluate effects on stone burden) ( Figure 1 ). Quantitative puterized tomography (CT) was used to assess changes in stone burden over the time of the study. Study Design and Conduct The protocol is illustrated in Figure 1. Patients were randomly assigned by Mayo Clinic Research Pharmacy to a 6 week treatment program with Cystonex000ae tablets, 2 by mouth twice daily, or identical placebo. This is the dose remended by the manufacturer. After a 1 week washout the patients crossed over to the alternate treatment for another 6 weeks. Patients provided two 24-hour urine collections shortly before starting the study, at the end of the first 6 weeks of treatment, and again at the end of the 6 week cross over, each of which were analyzed for determinants of urinary supersaturation in the Mayo Renal Function Laboratory and calculated using the Equil2 program.

5 After pleting both crossover arms, patients then immediately took Cystonex000ae open label in the same dose for an additional 48 weeks, thus ensuring a 52 week total exposure to Cystonex000ae during the 59 week study. Quantitative noncontrast multidetector CT exams were all performed on a 64-channel MDCT scanner (Sensation-64, Siemens Medical Solutions, Forschheim, Germany). For the 64-channel technique, patients were in the supine position on the CT table with arms above the head. An initial survey topogram was obtained for positioning purposes (80kVp, 300mA) from the top of the liver through the pubic symphysis. Subsequent CT images were obtained in a single breath-hold through the kidneys.

A standardized acquisition protocol was used for all exams (collimation 64x000d70.6 gantry rotation time, 0.5seconds table feed, 23mm/rotation (pitch of 1.2), quality reference 240 mAs 120 kVp and the field of view was adjusted to patient size). Three reconstruction intervals were obtained from the raw data including: 5.0mm thickness at 5.0mm intervals (axial), 2.0mm thickness at 2.0mm intervals (axial) and 2.0mm thickness at 2.0 intervals (coronal adjusted to the long axis of the kidneys). The 2.0mm thickness at 2.0mm interval (axial) data set was also processed at a free standing 3D workstation (Vitrea, Vital Images, Inc. Minnetonka, MN) by dedicated 3D technologists to obtain quantitative calcium scoring data for each kidney. All scored images were reviewed to determine that the included calcifications were consistent with urolithiasis rather than renal arterial or parenchymal calcifications.

The scoring programs are typically used for coronary artery calcification quantification and generate both an Agatston score (reported as Agatston Units, AU) and volumetric score (reported as mm 3 ). In the algorithms positive calcification required a minimum density threshold of 130 Hounsfield Units and a minimum area threshold of 3 adjacent pixels of at least 130 Hounsfield Units. In addition to quantified scoring, all images including the axial and reconstructed coronal series were reviewed by the diagnostic radiology service and a clinical report was generated. These images were subsequently sent to a picture archiving and munication system and available for referring clinicians. In addition, all images were reviewed by a radiologist (TJV) in a blinded fashion to score each kidney as increased, no change, or decreased stone burden.

Study Drug Cystonex000ae is traditionally used for relief of a variety of urological problems including nephrolithiasis and is prised of the following substances: shilapuspha ( Didymocarpus pedicellata ) 130mg, Pasanabheda ( Saxifaga lgulata Syn. Bergenia ligulata/ciliata ) 98 mg, Manjishtha ( Rubia cordifolia ) 32 mg, Nagarmusta ( Cyperus scariosus ) 32 mg, Apamarga ( Achyranthes aspera ) 32 mg, Gohija ( Onosma bracteatum ) 32 mg, Sahadevi ( Vernonia cinerea ) 32 mg, Shilajeet (Purified) 26 mg, and Hajrul yahood bhasma 32 mg. Its purported effect is to x0201cprevent supersaturation of lithogenic substances, control oxamide (a substance that precipitates stone formation) from the intestine and correct the crystalloid-colloid imbalance. Cystonex000ae inhibits calculogenesis by reducing stone-forming substances like oxalic acid, calcium hydroxyproline, etc, and causes their expulsion by micropulverization. Cystonex000ae causes disintegration of the calculi and crystals by acting on the mucin, which binds the particles together. Cystonex000aex02019s antimicrobial activity is beneficial in the prevention of urinary tract infections associated with urinary stones and crystalluria. Cystonex000aex02019s antispasmodic and anti-inflammatory activities relieve ureteric colic and alleviate symptoms of painful and burning and micturition. x0201d ( ). Cystonex000ae is manufactured and sold virtually world wide by Himalaya Health Care. In the United States, the product is known as Uricarex000ae. Statistics and Randomization Randomization was acplished using a table provided by the department of statistics to the study coordinator who was blinded as to whether the patients received placebo or Cystonex000ae.

Biochemical and supersaturation results were analyzed via a matched pair analysis using the JMP software package (SAS Instituted, Inc.) P values x0003c 0.05 were deemed significant. Table 2 displays the 24 hour urinary supersaturation results. In a matched pair analysis of the initial crossover study no statistically significant differences for any parameter between Cystonex000ae treatment as pared to placebo were present. Similarly, the 24-hour urine chemistries did not differ after one year on Cystonex000ae, as pared to values on placebo during the initial crossover period. Therefore there was no evidence that Cystonex000ae altered urinary chemistries after short term (6 weeks) or long term (1 year) usage.

No patients described any side effects attributable to Cystonex000ae, consistent with previous studies. Discussion Current non-surgical therapies of kidney stones take 3 different approaches. Prevention, either primary or secondary is preferred. Indeed, evidence exists that supports the prescription of specific dietary measures and/or drugs for this purpose. Chemolysis (dissolution) of existing stones may be possible with uric acid and some cystine stones. No scientific data supports the feasibility of calcium stone chemolysis, to our knowledge. Expulsion therapy to help pass stones that have moved into the ureter (but not stones resident in the kidney) is, however, supported by recent controlled trials. 6 Randomized controlled studies exist to support the efficacy of thiazides, 7 allopurinol, 8 and potassium magnesium citrate 9 for secondary prevention of calcium oxalate kidney stones. Side effects, cost, and imperfect prevention make the ready availability of cheap, safe and effective stone prevention therapy highly desirable.

Current treatments for stone prevention typically decrease urinary supersaturation by affecting urinary position (e. g. decrease calcium excretion). No agent is known that can be safely taken and enter the urine to decrease calcium oxalate crystallization, or perhaps even better dissolve calcium oxalate stones and/or crystals. If such a pound were found, it would represent a new class of treatment for renal stones. Several herbs have been purported to decrease stone risk, or hasten stone passage. However, hard scientific evidence regarding their efficacy is scanty.

The Chinese Kampou medicine has been used to treat disease for centuries, including for prevention and treatment of urinary calculi. An experimental study suggested an inhibitory effect of Kampou extracts on in vitro CaOx crystallization. 10 In this report, the two species from Kampou (Takusya and Kagosou) also were effective for preventing renal crystallization in a rat nephrolithiasis model similar results were obtained in a second report. 11 Chorey-to, another Chinese medicine which contains Takusya, also exhibited a protective effect in rats rendered hyperoxaluric with ethylene glycol, even though urinary citrate levels fell. 12 Many stone patients in Brazil take a tea made from the annual herb Phyllanthus niuri that grows in the tropical indigenous area and does not cause side effects. 12 This natural product has been called break stone because it has been used for generations to eliminate gallstones and kidney stones. 12 Diverse classes of potentially active pounds have been identified from genus Phyllanthus . including alkaloids, flavonoids, lactones, steroids, terpenoids, lignans, and tannins.

Some researchers have demonstrated antispasmodic and analgesic activities in Phyllanthus niuri which could explain the popular use of the plant for kidney and bladder stones. 12 ,13 The alkaloid extract caused smooth muscle relaxation specific to the urinary and biliary tract which could facilitate the expulsion of both kind of stones. 14 Phyllanthus niuri has also been shown to inhibit CaOx endocytosis by renal tubular cells, 15 another mechanism by which this agent could decrease crystal retention in the kidney, and in a small clinical trial appeared to reduce urinary calcium excretion amongst hypercalciuric stone formers. 16 No toxicity was apparent in the latter study. A Moroccan herb Hernaria hirsuta has similarly been evaluated for effects on CaOx crystallization, including by our group. 17 Interestingly, Phyllanthus niuri is purported to act by promoting nucleation of more crystals that achieve a smaller size.

A major shorting of prevention trials to date is the lack of adequate end points. Typically, the hard end point in most trials is stone passage rate, even though there has not been any data to suggest that any current treatment prevents passage of preformed stones. This formulation presumes relatively tight correlation between stone burden and stone passage rates. Although it is true that one cannot pass a stone unless it has developed and grown, the time between stone development and passage appears to be variable and unpredictable. Therefore, the ability to accurately measure stone size in vivo over time in vivo could represent a valuable surrogate end point for clinical trials in the future. Stone risk, position, and risk of recurrence all correlate with urinary supersaturation, as calculated using the iterative puter program Equil2. 18 Therefore, urinary supersaturation is a second potential surrogate endpoint for clinical trials. In this study we assessed the effect of Cystonex000ae, a mon stone prevention treatment outside of Europe and the United States, on both urinary supersaturation and radiographically assessed stone burden.

The current results did not document any beneficial effect of Cystonex000ae on the urinary position. However, the failure to find statistically significant change in urinary supersaturation does not rule out a beneficial effect. Equil2 only calculates SS based upon the inorganic position of urine, 5 and does not take into account the potential effect of potential macromolecular inhibitors such as Tamm-Horsfall protein or osteopontin, 19 or smaller molecules such as phytate. 20 Furthermore, Cystonex000ae could exert effects on other ion pairs that can form in urine and influence growth of calcium oxalate crystals, but are not included in the Equil2 calculations.

21 Cystonex000ae is purported to promote stone passage. However, on average stone burden increased rather than decreased in our study. It is important to note that stone formers in this study tended to be those who had failed standard therapy, which may have influenced the end point of stone formation and passage. It is also possible an effect may have been apparent with longer follow up. No patient reported any side effects from Cystonex000ae. This is in accord with previously published studies. Conclusion This short term study does not suggest that Cystonex000ae affects those urinary chemistries monly measured and known to influence calcium oxalate stone formation, nor does decrease renal calcium stone burden over a 1 year period. It is possible elements of the urine were affected that are not typically measured (e. g. glycoprotein inhibitors). A longer term study with more patients would be necessary to detect changes in stone events or enhanced stone passage, or effects on other stone types.

In any new study of Cystone, the botanical authenticity of each individual herb will need to be documented by the manufacturer using high pressure liquid chromatography. This short term trial failed to find evidence that Cystonex000ae prevents kidney stone formation and growth in recurrent calcium oxalate stone formers. Himalaya Cystone Beneficios de Cystone: Salud del tracto urinario, Rin Salud Cystone es una formulacin ayurvdica de hierbas y minerales. Cystone naturalmente promueve la salud del tracto urinario y ayuda a mantener la posicin normal de la orina y la integridad de la mucosa. Es una ayuda natural para mantener la gestin del agua saludable y alivia temporalmente el agua - el aumento de peso. o un suplemento diettico Cystone ayuda a los riones y el tracto urinario en las funciones normales. Proporciona la absorcin normal y la utilizacin de un tracto urinario saludable en general. Cmo funciona Cystone Cules son los beneficios de Cystone Cystone ayuda a limpiar el tracto urinario con seguridad y suavemente Cystone mantiene la posicin normal de la orina Cystone promueve la salud renal normal Cystone promueve la salud del tracto urinario normal Cystone alivia el tracto urinario mediante lavado sistmica Cystone apoya equilibrio normal de pH (acidez o alcalina) en la vejiga Ayuda en el apoyo al sistema inmunolgico Ayuda a prevenir los clculos urinarios Cules son los ingredientes de Cystone Ingredientes Principales(Por Tableta):Shilapuspha (Didymocarpus pedicellata) 130mg Pasanabheda (Saxifraga ligulata Syn. Bergenia ligulata / ciliata) 98mg Indian madder / Manjishtha (Rubia cordifolia) 32mg Umbrellas edge / Nagarmusta (Cyperus scariosus) 32mg Prickly chaff flower / Apamarga (Achyranthes aspera) 32mg Sedge / Gojiha (Onosma bracteatum) 32mg Purple fleabane / Sahadevi (Vernonia Cinerea) 32mg Lime silicate calx / Hajrul yahood Bhasma / Badrashma bhasma 32mg Shilajit 26mg Cystone Ingredientes en Ayurveda En la India, varias hierbas indgenas para mantener la salud del tracto urinario han estado en boga desde la antigedad Charak (600 BC) y Sushruta (1000 BC). Estas hierbas incluyen Didymocarpus pedicellata (Patharphor), Pashanabheda, Dolichos biflorus (Kulath), Rubia cordifolia (Manjit), Crataeva nurvala (Varuna) y Tamarindus indica (tamarindo).

Cystone, fabricado por The Himalaya Drogas Co. es una formulacin de este tipo de hierbas. Cmo las hierbas y minerales en Cystone promueven la salud del tracto urinario Didymocarpus pedicellata tambin conocido o Shilapushpa que literalmente significa flor de piedra es ampliamente utilizado en la medicina tradicional de la India por cuestiones renales. En la investigacin se estudia el extracto de la hierba se ha demostrado para proporcionar actividad antioxidante y proteger contra la oxidacin renal. Ligulata Saxifraga tambin conocido o Pasana bheda que literalmente significa aquello que rompe piedras se ha utilizado en ayurveda para mantener la salud renal y para la proteccin contra la litiasis vesical. Es conocido en Ayurveda por su capacidad para disolver los clculos. Rubia cordifolia o Manjistha Posee propiedades anti-bacterianas y diurticas que ayudan a proteger contra las infecciones del tracto urinario. Borde de Umbrella o Nagarmusta se utiliza en la medicina tradicional ayurvdica para reducir la inflamacin y es un agente desintoxicante que limpia los riones, el pncreas, el hgado, el bazo y el tero Flor paja espinoso o Apamarga ayuda para romper clculos, limpiar la sangre y tambin ayuda a reducir la inflamacin de los rganos internos. Tambin es antipirtico en la naturaleza Juncia o Gojiha se considera beneficioso para los riones, la prevencin de clculos renales y el sistema pulmonar Fleabane prpura o Sahadevi es til para reducir los espasmos de la vejiga, Purificacion sangre y el flujo urinario normalizadora Bhasma Yahood Hajrul es un polvo mineral fsil que contiene silicato de cal. Tiene propiedades diurticas y lithontriptic y ayuda a prevenir la retencin de orina. Shilajit ayuda a prevenir el ardor al orinar y permite el flujo de orina sin problemas.

Cules son las instrucciones para tomar Cystone Tome 2 tabletas dos veces al da con las idas. Puede aumentarse a 2 primidos tres veces al da, si es necesario. Permita varias semanas para beneficios. El uso de productos naturales ofrece los resultados progresivos y duraderos. Tiene Cystone tiene efectos secundarios Tiene Cystone tener contraindicaciones e interacciones medicamentosas Precauciones especiales Precauciones especiales han de ejercerse en pacientes con rin, hgado e insuficiencia cardaca que estn tomando medicamentos recetados.

Desde Cystone tambin est destinado a ayudar a las funciones renales y hepticas, debe informar a su mdico, ya que puede necesitar dosis de medicina para ser monitoreados Los efectos secundarios Cystone no produce efectos secundarios, si se toma o por la dosis prescrita. Interaccin con otros medicamentos No clnicamente y bioqumicamente interacciones farmacolgicas importantes han sido reportados con el uso de Cystone. Cystone de Himalaya Herbals Cystone es un producto de la famosa marca de Herbals Himalaya respaldado por ms de 250.000 mdicos de todo el mundo y utilizada por clientes en ms de 60 pases. Himalaya productos Herbals se han investigado clnicamente y estandarizado para garantizar bioequivalencia. Bioequivalencia se refiere a asegurar que el producto en el mercado es equivalente a aquella en la que se llevaron a cabo con xito los ensayos clnicos. Himalaya Herbal Healthcare utiliza la huella dactilar cromatogrfico, una de las ms sofisticadas tcnicas de normalizacin, para garantizar la calidad y rendimiento constante Cystone Investigacin y Estudios Clnicos Cystone ha sido sometido a diversos estudios clnicos para establecer sus beneficios para el tracto urinario y de los riones.

Diversos estudios de investigacin sobre Cystone se han documentado en revistas mdicas. Referencias: Himalaya Herbals panyPrevents stone formation in the urinary tract. Normalizes acidic urine and relieves burning urination. Reduces pain and inflammation. Has antibacterial action. Cystone treats stones in the urinary tract, and recurrent urinary tract infections. Cystone inhibits stone formation byReducing the concentration of stone forming substances in the blood and expelling them from the body. Breaking up stones by acting on mucin, a gummy substance which binds particles together. Normalizing acidic urine.

Reducing oxidative stress, which is implicated in urinary stone formation. Cystones antibacterial action along with its antibacterial, anti-inflammatory, pain relieving and urine pH normalizing actions prevent stone formation in the urinary tract and provide relief from pain and burning urination associated with urinary stones and urinary tract infections. Indications: Prevent and treat urinary stones. Prevent recurrence of stones after surgery. As an aid in preventing recurrence of urinary tract infections.

Aid in treating burning urination. Ingredients Include: Ginger (Zingiber officinale) Shilapuspha (Didymocarpus pedicellata) Pasanabheda (Saxifraga ligulata) Indian madder (Rubia cordifolia) Umbrellas edge (Cyperus scariosus) Prickly chaff flower (Achyranthes aspera) Sedge (Onosma bracteatum) Purple fleabane (Sahadevi) Lime silicate calx (Badrashma bhasma) Mineral pitch (Shilajeet) Use Directions: One tablet twice daily. Safety, Contraindications and Drug intractions: ContraindicationsThere are no contraindications for the use of Cystone Special precautionsSpecial precautions are to be exercised in patients with kidney, liver and heart impairment. Side effectsCystone does not produce any side effects, if taken as per the prescribed dosage. Drug intractionsNo clinically or biochemically significant drug intractions have been reported with the use of Cystone.

Cystone as a daily health supplement is specifically valuable in subjects prone to burning urination, repeated urinary infections or those who have a tendency to stone formation. Daily use of Cystone keeps the kidneys and the urinary tract flushed and working at optimum efficiency, due to its gentle amp safe diuretic effect, preventing the urinary tract from infections by acting on mon urinary pathogens. As a dietary supplement Cystone assists kidneys and urinary tract in normal functions. It provides normal absorption and utilization for overall healthy urinary tract. In a controlled trial of 100 cases, Cystone was pared with other methods, such as antispasmodics, to treat urinary problems. The results published in Current Medical Practice May 1992 show excellent results with Cystone in 76 of the cases. No side effects were observed even on prolonged use for 6 months.

Cystone treatment decreases the concentration of some risk factors in the urine of stone formers. It has been observed that if the urine position can be altered, the stones growth is stopped. Asian Med 1 (1985): 28.261. The study revealed that Cystone inhibits the precipitation of Calcium Phosphate or Calcium Oxalate salts. Ind. 1. Med. Res (1983): 78.422. Because of the significant fall observed in the uric acid levels Cystone is a valuable adjutant in benign prostatic enlargement (enlarged prostate). Cystone is useful as a diuretic in patients with heart problems. Clinical trial with Cystone proved the value of Cystone as a non-toxic diuretic. Cystone helps to prevent and remove kidney stone. Within weeks of taking Cystone the kidney stones will gradually disintegrate, get pulverized and pass through urine painlessly.

In most cases within 3 Months of taking Cystone you can expect plete relief from kidney stones. In about 20 of the cases the Cystone may have to be taken for another 3 months.106210801089109010861085 : - , - , , , , ( ) , , - - - , : . : (Didymocarpus pedicellata) 65 , (Saxifraga ligulata) 49 , (Rubia cordifolia) 16 , (Cyperus scariosus) 16 , (Achyranthes aspera) 16 , (Onosma bracteatum) 16 , (Vernonia cinerea) 16 , (Shilajeet purified) 13 (Hajrul Yahood Bhasma) 16 ), : : 2 2 . : 1 2 4-5.Cystone Tablets Ginger (Zingiber officinale) Shilapuspha (Didymocarpus pedicellata) Pasanabheda (Saxifraga ligulata) Indian madder (Rubia cordifolia) Umbrellas edge (Cyperus scariosus) Prickly chaff flower (Achyranthes aspera) Sedge (Onosma bracteatum) Purple fleabane (Sahadevi) Lime silicate calx (Badrashma bhasma) Mineral pitch (Shilajeet) Use Directions:One tablet twice daily. Safety, Contraindications and Drug intractions:Contraindications There are no contraindications for the use of Cystone Special precautions Special precautions are to be exercised in patients with kidney, liver and heart impairment. Side effects Cystone does not produce any side effects, if taken as per the prescribed dosage. Drug intractions No clinically or biochemically significant drug intractions have been reported with the use of Cystone. Presentation Sealed packs of 60 tablets. Allergies: An ayurvedic view Ayurveda, an ancient healing system is best for treating the urinary tract infection caused by bacteria in the urinary tract as it balances the infection-fighting properties of the urinary system. According to Ayurveda all living things are characterized by three active doshas Vata.

Pitta and Kapha and believes that aggravated Pitta produces heating toxins in the body which accumulate in the mutra vahi strota (urinary channels) causes UTI. Ayurvedas integrated approach to UTI includes a healthier life style, modified diet, intake of herbal supplements and practicing yoga as follows. Lifestyle : Mental feelings like excessive stress and anger are to be controlled. Not to sleep excessively in the daytime after eating. To go to bed early and get enough sleep at night Not to expose to sun and heat excessively Wear loose-fitting and cotton clothes. Diet : Drink plenty of water as it cleanses your body by diluting and flushing out the unwanted substance. Take Vitamin C rich diet as it prevents the bacterial growth due to the acidic environment created in the bladder and the urinary tract. Avoid processed food like cheese, chocolate and dairy products.

Do not take spicy food, caffeine, alcohol and cigarettes. Not to take carbonated drinks like beer, soda or any other drink with fizz. Avoid foods and drinks that are difficult to digest like white flour products. Herbal supplements: Ayurvedic herbs like Gokshura (Tribulus terrestris), Punarnava (Boerrhavia diffusa), Guduchi (Tinospora cordifolia), Chandan (Santalum album) are the effective natural cures.

Yoga : Gomukhasana (Cows face pose), Pawanmuktasana (The knee to chest), Ardha Matsendra Asana (Half spinal twist) are few useful yogic practices to fight UTI. In Ayurvedic medicine. the UTI treatment takes patience, discipline and a full mitment to ones health to restore balance but the results are well worth the effort. Allergies - Yoga and Life style Ayurveda. an integrated system of medicine emphasis on an ideal life style based on yoga which helps to remove stress and leads to relaxation which are extremely effective in reducing the allergy symptoms by tempering the immune systems response to the offender. a) Practicing yoga posture in a relaxing way with slow deep breathing relaxes the nervous system is beneficial in fighting allergies.

Kapalabhati breathing is great for allergies as it forces out the mucus. Standing poses8212forward and backward bends, and twists tends to massage various parts of the spine and the thoracic cage and condition the lungs. b) Lifestyle to be changed if one has a stressful job or home life. Meditation and relaxation techniques calms the nerves and loosen up muscles and treats allergy. c) Few guidelines for managing allergy are. Allergies aggravates when routine of life is hectic, so one should have a regular routine of life. Do yoga postures which strengthen the bodys natural resistance and helps the body block toxic reactions and strengthens the liver, which boosts the immunity.

Ayuvedic herbal preparations can be very beneficial, and some of the most promising anti-allergy herbs include: turmeric, Picrorhiza kurroa, Tinospora cordifolia, and Triphala. Taking Triphala helps keep the colon clean, which reduces the buildup of improperly digested food remains, and their associated toxins. Include detoxifying spices in your daily diet like turmeric which has anti-allergy, immune-balancing effects. Go to bed by 10:00 P. M as between 10 PM and 2 AM, the body performs a natural cycle of internal cleansing.

Eat the largest meal when you are most capable of digesting it i. e, between 12.00 and 1.00pm. Cold drinks, ice cream, frozen yogurt and other cold foods are to be avoided Avoid eating heavy evening meals, particularly after 7 PM. Avoid excessively hot spices, sour and acidic foods. Drinking alcohol or coffee should be stopped. Cleanse the body before the allergy season. Needless to say, Ayurveda is an alternative therapy which helps to lead a healthy balanced life and is an effective way of treatment for allergyCystone is a unique herbomineral formulation to treat and prevent urinary tract infection and stone formation.

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As an aid in preventing recurrence of urinary tract infections. Aid in treating burning urination. Ingredients Include: Use Directions: One tablet twice daily. Safety, Contraindications and Drug intractions: ContraindicationsThere are no contraindications for the use of Cystone Special precautionsSpecial precautions are to be exercised in patients with kidney, liver and heart impairment.

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Renormalises urinary pH and provides relief from pain associated with burning urination. Key Ingredients Include: Ginger (Zingiber officinale) Shilapuspha (Didymocarpus pedicellata) Pasanabheda (Saxifraga ligulata) Indian madder (Rubia cordifolia) Umbrellas edge (Cyperus scariosus) Prickly chaff flower (Achyranthes aspera) Action amp Benefits: Cystone prevents stone formation in the urinary tract, normalizes acidic urine and relieves burning urination, reduces pain and inflammation and has an antibacterial action. Cystones antibacterial action along with its antibacterial, anti-inflammatory, pain relieving and urine pH normalizing actions prevent stone formation in the urinary tract and provide relief from pain and burning urination associated with urinary stones and urinary tract infections. Quantity in stock No items available Dosage 1 Tablet Twice Daily Do not give to Children under 14 years Please maintain an hours gap between intake of our products or any other allopathic drugs. Our products will not interfere with any prescription medication you may be taking.

Cystone Syrup Urolithiasis. Oxalate stones Phosphate stones Uric acid and urate stones Crystalluria Prevents post-operative recurrence of stones Mixed crystals 8211 glycolic acids As an adjuvant in: Urinary tract infections Urinary tract infections during pregnancy Non-specific urethritis Cystitis, pyelitis Burning micturition Gout and hyperuricemia Urinary incontinence in women Sialolithiasis Ayurveda for Natural Health Diabetes 8211 Ayurvedic view According to Ayurveda an ancient healing system, one develops allergies when ojas (life force) is depleted amp when the immune system is weakened. High quality ojas is primarily built from proper digestion of wholesome foods, and is depleted through stress, lack of rest, toxic foods, irregular eating habits and routines amp turbulent emotions. Ayurvedic management of allergies includes : a) Diet. Nutrition and Digestion 8211 Allergies can be aggravated through improper diet. Foods that can be easily digested, creating nutrients that are then assimilated into the tissues to rebuild their strength is remended. Prepare foods in ways that create maximum nourishment for the body.

b) Stress Management and Improved Emotional Function-Allergies are worsened by heightened stress and mental fatigue. Sleep disturbance that is often created by symptoms of allergies increases fatigue, which in turn increases ones susceptibility to stress, which in turn aggravates the allergy condition. Meditation relieves the stress ponent of allergies . c) Lifestyle and Daily Routine 8211 Regularity in our daily routine is highly effective as one of the most important factors for balancing Vata and keeping the natural cleansing processes strong is to have a lifestyle that does not disturb natural bodily rhythms d) Ayurvedic Herbs - Appropriate herbal formulas is advised for aiding the healing process, strengthening digestion and helping the body purify itself. e) Herbalized Oil Massage 8211 Daily oil massage creates heat and friction which enhance circulation and help cleanse the areas of chemical impurities that could be causing symptoms of allergies. f) Cleansing therapies 8211 Treatment program of massage, application of herbalized preparations and mild internal cleansing therapies like panchakarma is the cornerstone of ayurvedic treatment. g) Exercise 8211 Ayurveda considers proper stretching and flexibility exercises to have a very positive effect on the bodys healing response and the treatment of allergies.

Yoga breathing practices that create a state of restful alertness in mind and body. Thus, Ayurveda is an integrated approach to allergy as it eliminates toxin buildup, stabilize the nervous system, enliven the healing ability of the body and manage stress and thereby strikes the allergy at its root. Urinary tract infection - Ayurveda viewIt is known as CYSTONE Himalaya cystone is one of the premier products that are being used world wide by people who suffer form ay trouble pertaining to urine. This herbal formulation is extremely beneficial in treating all your urinary tract problems. Himalaya Cystone is a powerful Ayurvedic formulation that prevents supersaturation of lithogenic substances, controls oxamide (a material that precipitates stone formation in the kidney) absorption from the intestine and rectifies the crystalloid-colloid imbalance in the body. Himalaya herbal Cystone restrains calculogenesis by dropping stone-forming substances like oxalic acid, calcium hydroxyproline, etc. and causes their exclusion by micro pulverization. Cystone (Tablets 038 Syrup) Benefits, Uses, Dosage 038 Side Effects Cystone (Tablets amp Syrup) is an ayurvedic proprietary medicine used for kidney stones, which is manufactured by Himalaya Herbal Healthcare (The Himalaya Drug pany). Cystone also provides support in chronic urinary tract infection and prevents recurrence of stone formation in the kidneys.

Ingredients (position) Medicinal Properties Cystone has following therapeutic action. Lithontriptic (lithotriptic) 8211 dissolves stones in the kidneys Diuretic Anti-lithiatic 8211 Prevents and inhibits stone formation in the kidneys Anti-microbial property 8211 appears in UTI Demulcent Anti-inflammatory Therapeutic Indications Kidney stones Crystalluria (crystals in the urine) Dysuria As adjuvant in UTIs Hyperuricemia (excess of uric acid in the blood) Burning urination Non-specific Urethritis (swelling or irritation of the urethra) Benefits amp Uses Due to diuretic, lithotriptic, Antilithiatic, anti-inflammatory and anti-microbial properties, Cystone helps dissolving, removing and preventing kidney stones and helps in urinary disorders. Kidney Stones Cystone is monly used for kidney stones and its prevention. Cystone ingredients act on almost all types of stones, help dissolving the stones, and flush out the stone gravel through the urine. Cystone contains several ingredients, which are potent Anti-lithiatic and lithotriptic agents. These ingredients help dissolving the stones and diuretic action of Cystone aids in flushing out the stone crystals through the urine. Cystone works well in following types of stones.

Calcium oxalate stones Uric acid stones Calcium and phosphate stones Cystone syrup can also be used in Pediatric urolithiasis. In children, it is best syrup based preparation available in the market for kidney stones. Bladder Stones Cystone is also beneficial for dissolving and eliminating urate bladder stones. For the best results, it should be used along with Chandanasava. It also helps clearing stone crystals and gravels. Burning micturition amp UTI Cystone has antimicrobial and anti-inflammatory properties. In bination with Chandanasava and Chandanadi Vati, Cystone reduces burning micturition and urinary tract infections. Recurrent formation of stones In some people, stone formation bees habitual.

They also require following kidney stone diet in addition to the treatment. Cystone along with Chandraprabha Vati helps preventing recurrence of the kidney stones. Crystalluria (presence of crystals in urine) In addition to stones, some medicines such as sulfonamides, penicillin or Ciprofloxacin can cause Crystalluria. Cystone and Chandraprabha Vati bination is best alternative treatment for Crystalluria. One may have to take this bination for several weeks to cure this problem. Cystone is available in syrup and tablets form. Its dosage is as follows.

Cystone in Renal Dysfunction The Antiseptic, (1974): 8, 452 Cystone in Renal Dysfunction G. T. Patel, M. D. (Med.) Asst. Associate Prof. of Medicine, Bangalore Medical College, Physician, Victoria Hospital, Bangalore, India The importance of diagnosing the underlying cause of renal dysfunction and giving appropriate treatment, cannot be sufficiently emphasized. This is relevant for several valid reasons, which include the possibility of its amelioration and the demonstration of the reversibility of the underlying pathology.

Particularly this is so when the prognosis is often in doubt as in acute or chronic renal failure and in patients with the nephrotic syndrome. The value of drugs like Cystone in such cases is therefore worth assessing. Cystone is claimed to be effective in treating crystalluria, urinary or salivary calculi and also because of its diuretic effect. REVIEW OF THE LITERATURE Cystone has been reported to act on the mucin in the calculi that bind the particles together and to allow the disintegrating particles to escape with the flow of urine. It also corrects the crystalloid - colloid balance8,5,6,1. The ingredients are of vegetable-mineral origin with no toxic action, even when given regularly over prolonged periods.

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Important Contributor Licensing Agreement, now required. by River at 3:34 AM (523 Views / 0 Likes) In order to protect all of our contributors and users legally, we are requiring the sign-off of a Contributor licensing agreement in order to submitmits to the Vizun Project. The CLA basically outlines the rights that you give to the project, and the rights that you retain of your intellectual property when youmit to the project. It also requires you to agree that you are submitting your code under the Apache 2 license. Adoption of a Code Style by River at 8:07 AM (878 Views / 0 Likes) We039ve adopted the Google Java Style for the project. We are moving to these standards as a way to keep all the code similar and readable. Holiday Extra 2014 HAPPY HOLIDAYS I want to begin by thanking all of our customers and friends that have been with us over the years. You are all great.

Lots of new things have begun here at Avalon Visions. If you havent been in for a while, its time to check us out. And, theres no time like the present. You may not know that during the holiday season until December 26, Capitola Village offers 3 free hours of parking. You dont have to do anything except park your car and enjoy yourself for 3 hours.

So, while you are out and about in the Village enjoying that free parking, stop in and visit us here at Avalon Visions. ly unique and locally made items are now again available. We have added local art, hand dyed scarves, locally made jewelry, locally made essential oil sprays, and many, many other items, most of which are very affordable and would make wonderful holiday gifts. We always offer 10 off on sterling silver chains when you buy a pendant, but for the rest of December you will get 15 off. Thanks to all of you, we pulled off the seemingly impossible. As other bookshops folded, we managed to expand. Little by little we are adding in products that you just cant find elsewhere. This year we have added in new clothing lines.

Mention our newsletter or our Facebook page and enjoy our special Dress-Down Friday discounts of 10-15 off on all clothing now through the end of the year. We know we cant meet all your needs without knowing what they are, so we are expanding on our special orders. Just let us know if you cant find something in particular. Well do our best to locate and order it for you. If we simply cant find something, well try to find something even better. Because Capitola seems to be a ghost town every time it gets overcast and rains, beginning in January through March, we will be introducing Brave the rainy day aura photo discounts. If its a rainy day and you are brave enough to venture into our little ghost town, Avalon Visions will reward your courage by offering Aura and Chakra reports for 30 instead of 35. If you havent been in recently, then you may not realize that this past year weve had a wee bit of consction while creating our new addition. Where there used to be a cigar store, you can now find an exciting mix of healers, readers, and of course, our aura camera. Our great group of readers include: Monique McDonnell, Michelle Bradshaw, Valerie OKelly, Sharon Dunn, Gwen Thomas, and Chere Miller.

Our list of healers now includes Richard Newton, Rebecca Madsen, Sandy Hagar, and Ona Tigue . Please check our website for their schedules. The rates for both the readers and the healers are 30 for 15 minutes. The aura reports are still 35. Currently, no appointment is necessary.

In the evenings, this new space is where we host our meetings and classes. Again, please check our website for the schedule of events. If you have any questions, feel free to give us a call at (831) 464-7245. We have several events in December. On Friday, December 12, radical astrologist, Hale Mednick, will again give his fascinating presentation on the art of sign shifting. Beginning December 18, through May 21, Chere Miller will begin teaching a Monthly Tarot Class every third Thursday of the month. Thanks to Dr. Alan Saxon, weve added a special documentary movie night on the last Monday of every month. Please check our website calendar for details or follow us on Facebook for current events and other postings.

Meet your Holiday Gift needs at Avalon Introducing: Dress-Down Fridays Every Friday Now Through December 31st All Clothing 10 8211 15 Off Find the Perfect ingredients Show Santa you have been good with a positive Aura MEET UP NEWS AND EVENTS AT AVALON Avalon Visions hosts a variety of Meetups throughout the month. Along with the regular events, Avalon also hosts a myriad of special workshops through out the year. THE PRACTICE OF TAROT Beginning in December Have you always wanted to learn to give a Tarot readinge to this fun class at Avalon Visions at 208 Monterey Avenue, Capitola Village starting Thursday December 18th from 7-9pm. Chere Miller has been doing readings since she was 15 and has studied with Amber Jayanti as well as other local readers and authors. You will need a Rider Waite deck which can be purchased at the store. We will meet once a month for six months December 18, 2014 to May 21, 2015 . You can sign up for the whole series or drop in for individual classes.

The cost is 25 per class or 20.00 per class if paid in advance. If you have questions please call Chere at 831-325-8129 Looking forward to meeting you RADICAL ASTROLOGY AND THE ART OF SIGN SHIFTING Have you ever wanted to be a different sun or moon sign for a day In this event, Hale Mednik will teach his unique skill of sign shifting, or changing your astrology sign at will. It will also be a lively discussion on the roots of the zodiac and proving astrology is real, as discussed in Hales new book, Radical Astrology and the art of Sign Shifting . Hale Mednik is also the author of the acclaimed epic novel, The Twelve Tribes. Friday December 12th, 7-9 pm.

Adalat CC Description Adalat reg CC is an extended release tablet dosage form of the calcium channel blocker nifedipine. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dimethyl ester, C 17 H 18 N 2 O 6. and has the structural formula: Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 346.3. Adalat CC tablets consist of an external coat and an internal core. Both contain nifedipine, the coat as a slow release formulation and the core as a fast release formulation. Adalat CC tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration. Inert ingredients in the formulation are: hydroxypropylcellulose, lactose, corn starch, crospovidone, microcrystalline cellulose, silicon dioxide, and magnesium stearate. The inert ingredients in the film coating for Adalat CC 30 and 60 are: hypromellose, polyethylene glycol, ferric oxide, and titanium dioxide. The inert ingredients in the film coating for Adalat CC 90 are: hypromellose, polyethylene glycol and ferric oxide Adalat CC - Clinical Pharmacology Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The contractile processes of vascular smooth muscle and cardiac muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Nifedipine selectively inhibits calcium ion influx across the cell membrane of vascular smooth muscle and cardiac muscle without altering serum calcium concentrations.

Mechanism of Action The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. The increased peripheral vascular resistance, an underlying cause of hypertension, results from an increase in active tension in the vascular smooth muscle. Studies have demonstrated that the increase in active tension reflects an increase in cytosolic free calcium. Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. Stores of intracellular calcium in vascular smooth muscle are limited and thus dependent upon the influx of extracellular calcium for contraction to occur. The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. Pharmacokinetics and Metabolism Nifedipine is pletely absorbed after oral administration. The bioavailability of nifedipine as Adalat CC relative to immediate release nifedipine is in the range of 84-89. After ingestion of Adalat CC tablets under fasting conditions, plasma concentrations peak at about 2.5-5 hours with a second small peak or shoulder evident at approximately 6-12 hours post dose.

The elimination half-life of nifedipine administered as Adalat CC is approximately 7 hours in contrast to the known 2 hour elimination half-life of nifedipine administered as an immediate release capsule. When Adalat CC is administered as multiples of 30 mg tablets over a dose range of 30 mg to 90 mg, the area under the curve (AUC) is dose proportional however, the peak plasma concentration for the 90 mg dose given as 3 x 30 mg is 29 greater than predicted from the 30 mg and 60 mg doses. Two 30 mg Adalat CC tablets may be interchanged with a 60 mg Adalat CC tablet. Three 30 mg Adalat CC tablets, however, result in substantially higher C max values than those after a single 90 mg Adalat CC tablet. Three 30 mg tablets should, therefore, not be considered interchangeable with a 90 mg tablet. Once daily dosing of Adalat CC under fasting conditions results in decreased fluctuations in the plasma concentration of nifedipine when pared to t. i.d. dosing with immediate release nifedipine capsules.

The mean peak plasma concentration of nifedipine following a 90 mg Adalat CC tablet, administered under fasting conditions, is approximately 115 ng/mL. When Adalat CC is given immediately after a high fat meal in healthy volunteers, there is an average increase of 60 in the peak plasma nifedipine concentration, a prolongation in the time to peak concentration, but no significant change in the AUC. Plasma concentrations of nifedipine when Adalat CC is taken after a fatty meal result in slightly lower peaks pared to the same daily dose of the immediate release formulation administered in three divided doses. This may be, in part, because Adalat CC is less bioavailable than the immediate release formulation. Nifedipine is extensively metabolized to highly water soluble, inactive metabolites accounting for 60 to 80 of the dose excreted in the urine. Only traces (less than 0.1 of the dose) of the unchanged form can be detected in the urine. The remainder is excreted in the feces in metabolized form, most likely as a result of biliary excretion. Nifedipine is metabolized via the cytochrome P450 3A4 system. Drugs that are known to either inhibit or induce this enzyme system may alter the first pass or clearance of nifedipine.

No studies have been performed with Adalat CC in patients with renal failure however, significant alterations in the pharmacokinetics of nifedipine immediate release capsules have not been reported in patients undergoing hemodialysis or chronic ambulatory peritoneal dialysis. Since the absorption of nifedipine from Adalat CC could be modified by renal disease, caution should be exercised in treating such patients. Because nifedipine is metabolized via the cytochrome P450 3A4 system, its pharmacokinetics may be altered in patients with chronic liver disease. Adalat CC has not been studied in patients with hepatic disease however, in patients with hepatic impairment (liver cirrhosis) nifedipine has a longer elimination half-life and higher bioavailability than in healthy volunteers. The degree of protein binding of nifedipine is high (92-98). Protein binding may be greatly reduced in patients with renal or hepatic impairment.

After administration of Adalat CC to healthy elderly men and women (age 60 years), the mean C max is 36 higher and the average plasma concentration is 70 greater than in younger patients. In healthy subjects, the elimination half-life of a different sustained release nifedipine formulation was longer in elderly subjects (6.7 h) pared to young subjects (3.8 h) following oral administration. A decreased clearance was also observed in the elderly (348 mL/min) pared to young subjects (519 mL/min) following intravenous administration. Co-administration of nifedipine with grapefruit juice results in up to a 2-fold increase in AUC and C max. due to inhibition of CYP3A related first-pass metabolism. Ingestion of grapefruit and grapefruit juice should be avoided while taking nifedipine. Clinical Studies Adalat CC produced dose-related decreases in systolic and diastolic blood pressure as demonstrated in two double-blind, randomized, placebo-controlled trials in which over 350 patients were treated with Adalat CC 30, 60 or 90 mg once daily for 6 weeks.

In the first study, Adalat CC was given as monotherapy and in the second study, Adalat CC was added to a beta-blocker in patients not controlled on a beta-blocker alone. The mean trough (24 hours post-dose) blood pressure results from these studies are shown below:About DailyMed DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts). This Web site provides a standard, prehensive, up-to-date, look-up and download resource of medication content and labeling found in medication package inserts. The National Library of Medicine (NLM) provides this as a public service and does not accept advertisements. The drug labeling information on this Web site is the most recent submitted to the Food and Drug Administration (FDA) and currently in use it may include, for example, strengthened warnings undergoing FDA review or minor editorial changes. These labels have been reformatted to make them easier to read.

Adalat CC generic prescription drugs Accepted at over 60,000 pharmacies nationwide Generic Name: nifedipine (nye FEH dih peen) What is Adalat CC Adalat CC is in a class of drugs called calcium channel blockers. Nifedipine relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload. Adalat CC is used to lower hypertension (high blood pressure) and to treat angina (chest pain). Adalat CC may also be used for purposes other than those listed in this medication guide. What is the most important information I should know about Adalat CC Do not stop taking Adalat CC without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could bee worse. Do not crush, chew, or break any form of Adalat CC. Swallow the pills whole.

Do not consume grapefruit or grapefruit juice during treatment with Adalat CC. Nifedipine can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects. You should discuss the use of grapefruit and grapefruit juice with your doctor. What should I discuss with my healthcare provider before taking Adalat CC Before taking Adalat CC, tell your doctor if you have kidney disease liver disease another disease of the heart or blood vessels such as sick sinus syndrome, aortic stenosis, heart failure, low blood pressure, or coronary artery disease. You may not be able to take Adalat CC, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Adalat CC is in the FDA pregnancy category C. This means that it is not known whether nifedipine will be harmful to an unborn baby. Do not take nifedipine without first talking to your doctor if you are pregnant or could bee pregnant during treatment. Adalat CC passes into breast milk. Do not take nifedipine without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from Adalat CC. Your doctor may prescribe a lower dose of this medication.

How should I take Adalat CC Take Adalat CC exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Adalat CC should be taken on an empty stomach. Do not crush, chew, or break any form of Adalat CC. Swallow the pills whole. Do not consume grapefruit or grapefruit juice during treatment with Adalat CC. Nifedipine can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects.

You should discuss the use of grapefruit and grapefruit juice with your doctor. Occasionally, the Procardia XL tablet shell may be seen in the stool. This is not harmful. The medicine has been absorbed by the body and the tablet shell is designed to be eliminated in the stool.

Do not stop taking Adalat CC without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could bee worse. Store Adalat CC at room temperature away from moisture and heat. What happens if I miss a dose Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication. What happens if I overdose Seek emergency medical attention. Symptoms of a Adalat CC overdose include dizziness, weakness, chest pain, shortness of breath, fainting, an unusually fast or slow heartbeat, a, slurred speech, and confusion.

What should I avoid while taking Adalat CC Do not consume grapefruit or grapefruit juice during treatment with Adalat CC. Nifedipine can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects. You should discuss the use of grapefruit and grapefruit juice with your doctor. Follow any remendations your doctor makes about diet or exercise. Use caution when you stand or sit up from a lying position, especially if you wake up during the night. You may bee dizzy when changing positions. Use alcohol cautiously. Alcohol may further lower blood pressure and increase drowsiness or dizziness while taking Adalat CC. What are the possible side effects of Adalat CC If you experience any of the following serious side effects, stop taking Adalat CC and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing closing of the throat swelling of the lips, tongue, or face or hives) unusually fast or slow heartbeats severe dizziness or fainting psychosis yellowing of the skin or eyes (jaundice) or swelling of the legs or ankles.

Other, less serious side effects may be more likely to occur. Continue to take Adalat CC and talk to your doctor if you experience headache, fatigue, or tiredness flushing insomnia vivid or abnormal dreams nausea or constipation or increased urination. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect Adalat CC Before taking Adalat CC, tell your doctor if you are taking any of the following drugs: another heart medication to treat the same or another condition cimetidine (Tagamet, Tagamet HB) erythromycin (E-Mycin, E. E.S. Eryc, Ery-Tab, others) itraconazole (Sporanox) or ketoconazole (Nizoral) carbamazepine (Tegretol) phenytoin (Dilantin) or rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).

You may not be able to take Adalat CC, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with Adalat CC or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products. Where can I get more information Your pharmacist has additional information about Adalat CC written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children. Never share your medicines with others and only use this medication for the condition prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (Multum) is accurate, up-to-date, and plete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been piled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multums drug information does not endorse drugs, diagnose patients or remend therapy. Multums drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug bination in no way should be construed to indicate that the drug or drug bination is safe, effective or appropriate for any given patient.

Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2009 Cerner Multum, Inc. Version: 7.02. Revision Date: 4/12/2009.

By Schering Corporation Last revised: 28 February 2011 ADALAT CC - nifedipine tablet, film coated Schering Corporation DESCRIPTION Adalat CC is an extended release tablet dosage form of the calcium channel blocker nifedipine. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dimethyl ester, C 17 H 18 N 2 O 6 . and has the structural formula: Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 346.3. Adalat CC tablets consist of an external coat and an internal core. Both contain nifedipine, the coat as a slow release formulation and the core as a fast release formulation. Adalat CC tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration. Inert ingredients in the formulation are: hydroxypropylcellulose, lactose, corn starch, crospovidone, microcrystalline cellulose, silicon dioxide, and magnesium stearate.

The inert ingredients in the film coating for Adalat CC 30 and 60 are: hypromellose, polyethylene glycol, ferric oxide, and titanium dioxide. The inert ingredients in the film coating for Adalat CC 90 are: hypromellose, polyethylene glycol and ferric oxide CLINICAL PHARMACOLOGY Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The contractile processes of vascular smooth muscle and cardiac muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Nifedipine selectively inhibits calcium ion influx across the cell membrane of vascular smooth muscle and cardiac muscle without altering serum calcium concentrations. Mechanism of Action The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. The increased peripheral vascular resistance, an underlying cause of hypertension, results from an increase in active tension in the vascular smooth muscle. Studies have demonstrated that the increase in active tension reflects an increase in cytosolic free calcium.

Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. Stores of intracellular calcium in vascular smooth muscle are limited and thus dependent upon the influx of extracellular calcium for contraction to occur. The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. Pharmacokinetics and Metabolism Nifedipine is pletely absorbed after oral administration. The bioavailability of nifedipine as Adalat CC relative to immediate release nifedipine is in the range of 84-89. After ingestion of Adalat CC tablets under fasting conditions, plasma concentrations peak at about 2.5-5 hours with a second small peak or shoulder evident at approximately 6-12 hours post dose.

The elimination half-life of nifedipine administered as Adalat CC is approximately 7 hours in contrast to the known 2 hour elimination half-life of nifedipine administered as an immediate release capsule. When Adalat CC is administered as multiples of 30 mg tablets over a dose range of 30 mg to 90 mg, the area under the curve (AUC) is dose proportional however, the peak plasma concentration for the 90 mg dose given as 3 x 30 mg is 29 greater than predicted from the 30 mg and 60 mg doses. Two 30 mg Adalat CC tablets may be interchanged with a 60 mg Adalat CC tablet. Three 30 mg Adalat CC tablets, however, result in substantially higher C max values than those after a single 90 mg Adalat CC tablet. Three 30 mg tablets should, therefore, not be considered interchangeable with a 90 mg tablet. Once daily dosing of Adalat CC under fasting conditions results in decreased fluctuations in the plasma concentration of nifedipine when pared to t. i.d. dosing with immediate release nifedipine capsules.

The mean peak plasma concentration of nifedipine following a 90 mg Adalat CC tablet, administered under fasting conditions, is approximately 115 ng/mL. When Adalat CC is given immediately after a high fat meal in healthy volunteers, there is an average increase of 60 in the peak plasma nifedipine concentration, a prolongation in the time to peak concentration, but no significant change in the AUC. Plasma concentrations of nifedipine when Adalat CC is taken after a fatty meal result in slightly lower peaks pared to the same daily dose of the immediate release formulation administered in three divided doses. This may be, in part, because Adalat CC is less bioavailable than the immediate release formulation. Nifedipine is extensively metabolized to highly water soluble, inactive metabolites accounting for 60 to 80 of the dose excreted in the urine. Only traces (less than 0.1 of the dose) of the unchanged form can be detected in the urine. The remainder is excreted in the feces in metabolized form, most likely as a result of biliary excretion. Nifedipine is metabolized via the cytochrome P450 3A4 system. Drugs that are known to either inhibit or induce this enzyme system may alter the first pass or clearance of nifedipine. No studies have been performed with Adalat CC in patients with renal failure however, significant alterations in the pharmacokinetics of nifedipine immediate release capsules have not been reported in patients undergoing hemodialysis or chronic ambulatory peritoneal dialysis.

Since the absorption of nifedipine from Adalat CC could be modified by renal disease, caution should be exercised in treating such patients. Because nifedipine is metabolized via the cytochrome P450 3A4 system, its pharmacokinetics may be altered in patients with chronic liver disease. Adalat CC has not been studied in patients with hepatic disease however, in patients with hepatic impairment (liver cirrhosis) nifedipine has a longer elimination half-life and higher bioavailability than in healthy volunteers. The degree of protein binding of nifedipine is high (92-98). Protein binding may be greatly reduced in patients with renal or hepatic impairment. After administration of Adalat CC to healthy elderly men and women (age 60 years), the mean C max is 36 higher and the average plasma concentration is 70 greater than in younger patients. In healthy subjects, the elimination half-life of a different sustained release nifedipine formulation was longer in elderly subjects (6.7 h) pared to young subjects (3.8 h) following oral administration. A decreased clearance was also observed in the elderly (348 mL/min) pared to young subjects (519 mL/min) following intravenous administration. Co-administration of nifedipine with grapefruit juice results in up to a 2-fold increase in AUC and C max, due to inhibition of CYP3A related first-pass metabolism. Ingestion of grapefruit and grapefruit juice should be avoided while taking nifedipine.

Clinical Studies Adalat CC produced dose-related decreases in systolic and diastolic blood pressure as demonstrated in two double-blind, randomized, placebo-controlled trials in which over 350 patients were treated with Adalat CC 30, 60 or 90 mg once daily for 6 weeks. In the first study, Adalat CC was given as monotherapy and in the second study, Adalat CC was added to a beta-blocker in patients not controlled on a beta-blocker alone. The mean trough (24 hours post-dose) blood pressure results from these studies are shown below:Procardia XL 90 mg round, pink, imprinted with PROCARDIA XL 90 What are the possible side effects of nifedipine (Procardia) Get emergency medical help if you have any of these signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as: worsening angina severe constipation and cramps, severe stomach pain or heartburn. coughing up blood feeling like you might pass out feeling short of breath, swelling in your hands or feet fast or pounding heartbeats numbness or tingly feeling jaundice (yellowing of the skin or eyes) or chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling. Less serious side effects may include: headache.

dizziness drowsiness, tired feeling nausea, diarrhea mild constipation or stomach pain sleep problems (insomnia ) mild rash or itching joint pain. leg cramps warmth, redness, or tingly feeling under your skin or urinating more than usual. This is not a plete list of side effects and others may occur. Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about nifedipine (Procardia) You should not use nifedipine if you are allergic to it. Before taking nifedipine, tell your doctor if you have kidney or liver disease, a blockage in your digestive tract (stomach or intestines), a history of stomach surgery, coronary artery disease, underactive thyroid. diabetes. or congestive heart failure . If you need surgery, tell the surgeon ahead of time that you are using nifedipine. You may need to stop using the medicine for a short time.

Many drugs can interact with nifedipine. Tell your doctor about all other medications you use. Do not stop taking nifedipine without first talking to your doctor, even if you feel fine. Stopping suddenly may make your condition worse. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Nifedipine (Procardia, Adalat, Procardia XL, Adalat CC) Miscellaneous Antihypertensive, antianginal (calcium channel blocker) Vasospastic (Prinzmetal146s or variant) angina Chronic stable angina Hypertension Contraindications: Use of sustained-release preparations in patients with severe obstructive coronary artery disease or recent MI Hypertensive emergencies Pregnancy category C has been used in pregnant women patible with breast feeding Adverse Reactions (Side Effects): CNS: anxiety, asthenia, depression, dizziness, headache, insomnia, somnolence, tremor GI: abdominal cramps, constipation, diarrhea, flatulence, dry mouth, nausea, vomiting GU: Nocturia, polyuria SKIN: hair loss, pruritus, rash, urticaria MISC: cough, epistaxis, flushing, muscle cramps, nasal congestion, sexual dysfunction, shortness of breath, sweating, tinnitus, weight gain Administered orally (capsule, sustained release tablet)Adult:PO 10mg 3 times daily initially, usual range 10-20mg 3 times daily doses 120 mg/day are rarely necessaryAdalat CC 30mg Tablets Product Summary PRESCRIPTION REQUIRED IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for plete information about this product and your specific health needs. NIFEDIPINE SUSTAINED-ACTION - ORAL (nye-FED-i-peen) MON BRAND NAME(S): Adalat CC USES: This medication is used alone or in bination with other drugs to treat high blood pressure (hypertension).

Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Nifedipine belongs to a class of medications known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used for certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. This medication must be taken regularly to be effective. It should not be used to treat attacks of chest pain when they occur. Use other medications (e. g. sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor. Consult your doctor or pharmacist for details.

This medication may also be used to treat certain blood circulation disorders (Raynauds syndrome). HOW TO USE: Take this medication by mouth on an empty stomach, usually once daily or as directed by your doctor. Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Your doctor may gradually increase your dose. Follow your doctors instructions carefully. Dosage is based on your medical condition and response to treatment. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise.

Grapefruit juice can increase the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Do not suddenly stop taking this medication without consulting your doctor. Your condition may bee worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

Tell your doctor if your condition worsens (e. g. increase in your routine blood pressure readings). SIDE EFFECTS: Headache, dizziness, nausea, flushing, constipation, leg/muscle cramps, or sexual problems may occur. To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling of the ankles/feet, shortness of breath, unusual weakness/tiredness. Tell your doctor immediately if any of these rare but very serious side effects occur: fast/slow/irregular heartbeat, fainting, mental/mood changes, swollen/tender gums, vision changes. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a plete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it or to other calcium channel blockers (e. g. felodipine, amlodipine) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (e. g. congestive heart failure, aortic stenosis), liver problems, kidney problems, a certain metabolic disorder (porphyria). Before having surgery, tell your doctor or dentist that you are taking this medication. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Nifedipine passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding. DRUG INTERACTIONS: See also How to Use section. Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alpha blockers (e. g. doxazosin), beta blockers (e. g. propranolol, metoprolol), calcium or magnesium sulfate received through a vein, digoxin, fentanyl, melatonin, quinidine, certain drugs that may weaken the immune system (e. g. sirolimus, tacrolimus), drugs affecting liver enzymes that remove nifedipine from your body (e. g. cimetidine, nefazodone, quinupristin/dalfopristin, St. Johns wort, azole antifungals such as itraconazole, macrolide antibiotics such as erythromycin, rifamycins such as rifampin, anti-seizure medicines such as carbamazepine/phenytoin). Check the labels on all your medicines (e. g. cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure or heart rate (e. g. pseudoephedrine, phenylephrine, chlorpheniramine, diphenhydramine, clemastine, ibuprofen, naproxen). Ask your pharmacist about using those products safely. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting, fast/slow/irregular heartbeat.

NOTES: Do not share this medication with others. Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Laboratory and/or medical tests (e. g. liver or kidney function tests, EKG) may be performed from time to time to monitor your progress or check for side effects. Consult your doctor for more details. Have your blood pressure checked regularly while taking this medication. Learn how to monitor your own blood pressure at home, and share the results with your doctor. There are different tablet strengths of this medication available. Some tablet strengths may not be used in place of others.

Do not change tablet strengths or use a different number of tablets for your dose without consulting your doctor or pharmacist. MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. STORAGE: Store at room temperature below 86 degrees F (30 degrees C) away from light and moisture.

Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal pany for more details about how to safely discard your product. MEDICAL ALERT: Your condition can cause plications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada). Information last revised May 2012. Copyright(c) 2012 First Databank, Inc. As a VIPPS accredited pharmacy licensed in all 50 states, we only sell FDA approved medications as is required by law. PRINCIPAL DISPLAY PANEL 8212 90mg Revised: 05/2014 Aphena Pharma Solutions 8212 Tennessee, LLC DrugInserts provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the US Food and Drug Administration.

Package information is not reviewed or updated separately by DrugInserts. Every individual package label entry contains a unique identifier which can be used to secure further details directly from the US National Institutes of Health and/or the FDA. Clinical Trials FDA MedWatch Trustworthy Health InformationNifedipine (Procardia XL174, Adalat CC174) Nifedipine (Procardia XL, Adalat CC) is used to treat high blood pressure (hypertension) in children who have undergone liver transplantation. Nifedipine is a calcium-channel blocker. It blocks the movement of calcium into the heart muscle and blood vessels.

As a result, the heart muscle relaxes and blood vessels open (dilate), lowering blood pressure. Types Available Nifedipine is usually taken by mouth. It is available as capsules and tablets. Procardia XL, Adalat CC are extended-release tablets that available in 30-, 60-, and 90-mg doses. How to Take Nifedipine can be taken with or without food.

Your child should swallow the tablet whole without chewing, breaking or crushing it. Avoid drinking grapefruit juice one hour before or two hours after taking nifedipine. Missed Doses If your child misses a dose, take it as soon as you or your child remembers. If the time is within two hours of the next scheduled dose, skip the missed dose and resume your childs usual dosing schedule. Do not double the dose to catch up. Side Effects mon side effects that may occur but should disappear as your childs body adjusts to the medication include: Dizziness or lightheadedness (especially during the first few days). Getting up slowly helps minimize dizziness. bloating heartburn nausea blurred vision muscle cramps weakness headache flushing sweating sleep disturbances Rare side effects include: breathing difficulties swelling of the hands or feet chest pain or irregular heartbeat tender bleeding or swollen gums shortness of breath constipation If your child has trouble with any of these, inform your transplant doctor or transplant coordinator. Note: The empty tablet shell may appear in your childs stool. Do not be concerned the medication has already been absorbed into his or her body. Drug Interactions Tell your coordinator and/or pharmacist about any other prescription or over-the-counter medications your child is taking, so you can be warned of undesirable interactions and prevent them.

Drug information changes periodically. For the most updated information on drugs, visit drugs. What is Adalat CC (nifedipine) Adalat CC (nifedipine) is a prescription drug that is used for the long-term treatment of high blood pressure. By lowering high blood pressure, Adalat CC decreases the risk of kidney disease, heart attacks and strokes. Adalat CC should not be used in the acute treatment of critically high blood pressure. Adalat CC contains the active ingredient nifedipine, a calcium channel blocker. A calcium channel blocker widens the blood vessels in the body so blood can flow more easily. This ultimately reduces stress on the heart because it does not need to pump as hard to move blood through the body.

Adalat CC is often prescribed for other conditions, though it is only FDA-approved as a long-term treatment for high blood pressure. When used to treat angina, Adalat CC may improve your tolerance for exercise and may reduce the occurrence of chest pain attacks caused by angina. Other off-label uses include: treatment of migraine headaches, kidney problems due to diabetes and hiccups. Adalat CC is a specially formulated, extended-release version of nifedipine that only needs to be taken once a day. It es in pill form and is taken by mouth.

Generic forms are available and marketed under the names Nifedipine ER, Nifediac CC and Afeditab CR. The generic form has been shown to be as effective as Adalat CC.