Aldactonespironolactone Aldactone, Novo-Spiroton (CA) Pharmacologic class: Aldosterone inhibitor Therapeutic class: Potassium-sparing diuretic Pregnancy risk category D FDA Box Warning Drug induced tumors in chronic toxicity studies in rats. Use only in conditions listed under quotIndications and dosages. quot Avoid unnecessary use. Availability Tablets: 25 mg, 50 mg, 100 mg x2298 Indications and dosages x27A3 Edema caused by heart failure, hepatic cirrhosis, or nephrotic syndrome Adults: As sole diuretic, initially 100 mg/day P. O. (range of 25 to 200 mg) in single or divided doses, continued for 5 or more days and then adjusted to optimal therapeutic level Children: 1 to 3 mg/kg/day P. O. as a single dose or in divided doses x27A3 Essential hypertension Adults: Initially, 50 to 100 mg/day P. O. as a single dose or in divided doses, continued for at least 2 weeks Children: 1 to 2 mg/kg P. O. b. i.d. x27A3 Hypokalemia Adults: 25 to 100 mg/day P. O. x27A3 Diagnosis and treatment of primary hyperaldosteronism Adults: For diagnosis, 400 mg/day P. O. for 4 days in short test or for 3 to 4 weeks in long test. Resolution of hypokalemia and hypertension confirm diagnosis of primary hyperaldosteronism. Dosages of 100 to 400 mg/day P. O. may be used as a bridge to surgical therapy in patients unsuitable for this therapy, lowest effective dosage may be used for long-term maintenance. Generic Name: Spironolactone What is Aldactone Aldactone is a diuretic medication used to control high blood pressure. It is also used to treat hyperaldosteronism (an increase in a hormone called aldosterone which can cause an increase in blood pressure), other conditions that require the elimination of excess fluid from the body (such as congestive or severe heart failure, and kidney disease), and to treat or prevent low potassium levels in the blood. What is the most important information I should know about Aldactone Aldactone only controls high blood pressure it does not cure it. You must take Aldactone regularly for it to be effective. If you have severe heart failure, your doctor will need to monitor your potassium levels during treatment with Aldactone. Who should not take Aldactone Do not take Aldactone if you are allergic to any of its ingredients, and if you have kidney disease, difficulty urinating, or high potassium levels.

What should I tell my doctor before I take the first dose of Aldactone Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Aldactone. Also, talk to your doctor about your plete medical history, especially if you have kidney problems, liver disease, severe heart failure, are taking potassium supplements, or if you are going to have surgery while taking Aldactone. What is the usual dosage The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctors approval.

High Blood Pressure Adults . The usual starting dose is 50-100 milligrams (mg) daily in single or divided doses. This medication may be given with another diuretic or with other blood pressure medications. Fluid Retention Adults: The usual starting dose is 100 mg daily either in single or divided doses doses may vary between 25-200 mg daily. Adults: The usual dose is 25-100 mg per day when potassium cannot be replaced with a supplement. Severe Heart Failure Adults: The usual starting dose is 25 mg once daily, depending on your potassium levels and kidney function. How should I take Aldactone What should I avoid while taking Aldactone Avoid potassium supplements and foods containing high levels of potassium, including salt substitutes.

Also avoid drinking alcohol. Avoid being overheated or dehydrated during exercise and in hot weather. Follow your doctors instructions about the type and amount of liquids you should drink. What are possible food and drug interactions associated with Aldactone What are the possible side effects of AldactoneSpironolactone is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks. and kidney problems. It is also used to treat swelling (edema ) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems . This medication is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone).

Spironolactone is known as a water pill (potassium - sparing diuretic). OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication has also been used to treat excessive hair growth (hirsutism ) in women with polycystic ovary disease. How to use Aldactone Take this medication by mouth. as directed by your doctor. If stomach upset occurs, take it with food or milk. It is best to take your dose early in the day (before 6 p. m.) to prevent having to get up during the night to urinate.

Consult your doctor or pharmacist if you have any questions. Dosage is based on your medical condition and response to therapy. In children, the dosage is also based on body weight . Take this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day as directed.

It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Take this medication exactly as prescribed. Do not increase your dose, take it more often than prescribed, or stop using this medicine without first consulting your doctor.

Your condition may bee worse when the drug is suddenly stopped. Inform your doctor if your condition worsens (e. g. if you notice an increase in your routine blood pressure readings ). Side Effects Drowsiness, dizziness. lightheadedness, stomach upset, diarrhea. nausea. vomiting. or headache may occur.

To minimize lightheadedness, get up slowly when rising from a seated or lying position. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: increased thirst, change in the amount of urine, mental/mood changes, unusual fatigue /weakness. muscle spasms. menstrual period changes, breast pain. breast enlargement (gyneastia ) in men, sexual function problems, signs of infection (e. g. fever, persistent sore throat ), severe stomach/abdominal pain.

persistent nausea/vomiting, vomit that looks like coffee grounds, dark urine, yellowing of the eyes /skin. easy bruising/bleeding. This medication may lead to high levels of potassium, especially in patients with kidney problems. If not treated, very high potassium levels can be fatal. Tell your doctor right away if you notice any of the following serious side effects: slow/irregular heartbeat.

muscle weakness. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash.

itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing. This is not a plete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at fda. gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions Before taking spironolactone, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies.

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, untreated mineral imbalance (such as high potassium, low sodium ), decreased adrenal gland function (Addisons disease ). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medication may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Limit foods high in potassium such as bananas, tomatoes, potatoes, and low-salt milk. Consult your doctor or pharmacist for more details, including remendations.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Older adults may be more sensitive to the side effects of this drug, especially the effects on potassium (see Side Effects section). This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk but is unlikely to harm a nursing infant.

Consult your doctor before breast-feeding. Interactions See also Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctors approval. Some products that may interact with this drug include: lithium, drugs that may increase the level of potassium in the blood (such as amiloride, cyclosporine, eplerenone, tacrolimus, triamterene, birth control pills containing drospirenone). Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure or worsen swelling (edema).

This medication may interfere with certain laboratory tests (including digoxin or cortisol levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Do not share this medication with others.

Laboratory and/or medical tests (such as kidney/liver function, blood mineral levels such as potassium) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. If you are taking this medication for high blood pressure, lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Have your blood pressure checked regularly while taking this medication. Discuss with your doctor and learn how to monitor your own blood pressure. Inform your doctor of your blood pressure readings. Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Store at room temperature away from light and moisture.

Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal pany. Information last revised October 2015. Copyright(c) 2015 First Databank, Inc. What Is Spironolactone (Aldactone) 51 Reviews Spironolactone is the generic form of the brand-name drug Aldactone.

a prescription diuretic drug. The drug is used to treat a condition called primary hyperaldosteronism, in which the body produces excess amounts of the hormone aldosterone, which regulates your bodyrsquos sodium and water levels. Spironolactone helps restore a healthy balance of sodium and potassium in your body. Itrsquos also used to treat: Essential hypertension (high blood pressure with an unknown cause) Hypokalemia (potassium deficiency) Edema (fluid retention) from various conditions, including congestive heart failure, kidney disease, and cirrhosis (liver scarring) Severe heart failure Spironolactone is a potassium-sparing diuretic. Sometimes called quotwater pills, quot diuretics help the kidneys expel water and salt in urine while retaining potassium. The drug may also be used in bination with other medications to treat precocious (early) puberty and myasthenia gravis. a neuromuscular disease. Manufactured by Pfizer, s pironolactone was approved by the Food and Drug Administration (FDA) in 1985. Though s pironolactone has been around for over 25 years, the FDA is still updating the drug39s safety labeling.

In 2011, the FDA added Stevens-Johnson syndrome and toxic epidermal necrolysis mdash two life-threatening skin disorders mdash to s pironolactone 39s list of possible side effects. In 2013, the agency added a warning about a potentially fatal condition called hyperkalemia (high potassium levels in the blood). Spironolactone for Acne Spironolactone is sometimes used off-label to treat women with persistent adult acne due to increased androgen levels, because the drug is able to inhibit the activity of sebaceous glands (small skin glands that releases an oily, lubricating substance called sebum). The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess. Spironolactone for Hair Loss and Hirsutism Because of its anti-androgen activity, s pironolactone is also used off-label to treat female-pattern hair loss and hirsutism. Women with certain endocrine disorders produce more androgens than normal, leading to hair loss on the top or front of the scalp, and increased hair on the face and other (generally hair-free) body areas. Spironolactone helps by slowing down the production, and blocking the action, of androgens.

Spironolactone Warnings Spironolactone carries a black-box warning for tumor risk, due to chronic toxicity studies that show spironolactone can cause tumor development in rats. Spironolactone shouldn39t be taken with potassium-supplementing drugs or diets because the excessive potassium intake may cause hyperkalemia, which can lead to abnormal heart rhythms (arrhythmias). Your doctor should also know if you have severe heart failure, because hyperkalemia has an increased risk of death in such cases. Additionally, tell your doctor if you have liver problems such as cirrhosis, as even minor changes in fluid and electrolyte balance may cause liver-related a. Spironolactone shouldn39t be used if you have certain kidney problems or conditions associated with hyperkalemia, including the adrenal gland disorder known as Addison39s disease. Pregnancy and Spironolactone Spironolactone may pose risks to a developing fetus. Some research suggests that s pironolactone has the potential to feminize male fetuses during early pregnancy and cause endocrine problems in late pregnancy by inhibiting the activity of male hormones (androgens). In general, diuretics such as s pironolactone aren39t remended for pregnant women. Unless the drug is absolutely necessary, it39s not remended for women who are breastfeeding because canrenone, a byproduct of s pironolactone.

is excreted in breast milk. What is Aldactone Aldactone (spironolactone) is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Aldactone is used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body. Aldactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication is also used to treat or prevent hypokalemia (low potassium levels in the blood). Aldactone may also be used for purposes not listed in this medication guide. Important information You should not use Aldactone if you have kidney disease, high levels of potassium in your blood, Addisons disease (an adrenal gland disorder), if you are unable to urinate, or if you are also taking eplerenone.

Slideshow: Whats That 10 Of The Most mon Skin Conditions Before taking this medicineINDICATIONS ALDACTONE (spironolactone) is indicated in the management of: Primary hyperaldosteronism for: Establishing the diagnosis of primary hyperaldosteronism by therapeutic trial. Short-term preoperative treatment of patients with primary hyperaldosteronism. Long-term maintenance therapy for patients with discrete aldosterone - producing adrenal adenomas who are judged to be poor operative risks or who decline surgery. Long-term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism). Edematous conditions for patients with: Congestive heart failure : For the management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures. ALDACTONE is also indicated for patients with congestive heart failure taking digitalis when other therapies are considered inappropriate. Cirrhosis of the liver acpanied by edema and/or ascites : Aldosterone levels may be exceptionally high in this condition.

ALDACTONE is indicated for maintenance therapy together with bed rest and the restriction of fluid and sodium. Nephrotic syndrome : For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response. Essential Hypertension ALDACTONE is indicated for the treatment of hypertension. to lower blood pressure.

Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. Control of high blood pressure should be part of prehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Programs Joint National mittee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular oute benefit has been a reduction in the risk of stroke. but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia ), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e. g. on angina. heart failure. or diabetic kidney disease). These considerations may guide selection of therapy. Usually in bination with other drugs, ALDACTONE is indicated for patients who cannot be treated adequately with other agents or for whom other agents are considered inappropriate. Hypokalemia For the treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate.

ALDACTONE is also indicated for the prophylaxis of hypokalemia in patients taking digitalis when other measures are considered inadequate or inappropriate. Severe Heart Failure (NYHA class III ndash IV) To increase survival, and to reduce the need for hospitalization for heart failure when used in addition to standard therapy. Usage In Pregnancy The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developing toxemia. Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. ALDACTONE is indicated in pregnancy when edema is due to pathologic causes just as it is in the absence of pregnancy (however, see PRECAUTIONS . Pregnancy ).

Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus. is properly treated through elevation of the lower extremities and use of support hose use of diuretics to lower intravascular volume in this case is unsupported and unnecessary. There is hypervolemia during normal pregnancy which is not harmful to either the fetus or the mother (in the absence of cardiovascular disease ), but which is associated with edema, including generalized edema, in the majority of pregnant women. If this edema produces disfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme disfort that is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate. DOSAGE AND ADMINISTRATION ALDACTONE may be employed as an initial diagnostic measure to provide presumptive evidence of primary hyperaldosteronism while patients are on normal diets. ALDACTONE is administered at a daily dosage of 400 mg for three to four weeks. Correction of hypokalemia and of hypertension provides presumptive evidence for the diagnosis of primary hyperaldosteronism.

Short Test ALDACTONE is administered at a daily dosage of 400 mg for four days. If serum potassium increases during ALDACTONE administration but drops when ALDACTONE is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered. After the diagnosis of hyperaldosteronism has been established by more definitive testing procedures, ALDACTONE may be administered in doses of 100 to 400 mg daily in preparation for surgery. For patients who are considered unsuitable for surgery, ALDACTONE may be employed for long-term maintenance therapy at the lowest effective dosage determined for the individual patient.

Edema In Adults (Congestive Heart Failure, Hepatic Cirrhosis, Or Nephrotic Syndrome) An initial daily dosage of 100 mg of ALDACTONE administered in either single or divided doses is remended, but may range from 25 to 200 mg daily. When given as the sole agent for diuresis. ALDACTONE should be continued for at least five days at the initial dosage level, after which it may be adjusted to the optimal therapeutic or maintenance level administered in either single or divided daily doses. If, after five days, an adequate diuretic response to ALDACTONE has not occurred, a second diuretic that acts more proximally in the renal tubule may be added to the regimen. Because of the additive effect of ALDACTONE when administered concurrently with such diuretics, an enhanced diuresis usually begins on the first day of bined treatment bined therapy is indicated when more rapid diuresis is desired. The dosage of ALDACTONE should remain unchanged when other diuretic therapy is added.

Essential Hypertension For adults, an initial daily dosage of 50 to 100 mg of ALDACTONE administered in either single or divided doses is remended. ALDACTONE may also be given with diuretics that act more proximally in the renal tubule or with other antihypertensive agents. Treatment with ALDACTONE should be continued for at least two weeks since the maximum response may not occur before this time. Subsequently, dosage should be adjusted according to the response of the patient. ALDACTONE in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia, when oral potassium supplements or other potassium-sparing regimens are considered inappropriate. Treatment should be initiated with ALDACTONE 25 mg once daily if the patients serum potassium is le 5.0 mEq/L and the patients serum creatinine is le 2.5 mg/dL. Patients who tolerate 25 mg once daily may have their dosage increased to 50 mg once daily as clinically indicated. Patients who do not tolerate 25 mg once daily may have their dosage reduced to 25 mg every other day. See WARNINGS. Hyperkalemia in patients with severe heart failure for advice on monitoring serum potassium and serum creatinine.

Aldactone reg Aldactone has been shown to be a tumorigen in chronic toxicity studies in rats (see Precautions ). Aldactone should be used only in those conditions described under Indications and Usage. Unnecessary use of this drug should be avoided. Aldactone Description Aldactone oral tablets contain 25 mg, 50 mg, or 100 mg of the aldosterone antagonist spironolactone, 17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid gamma-lactone acetate, which has the following structural formula: Slideshow: Newly Approved Weight Loss Drugs - Can They Help You Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. ACTIONS / CLINICAL PHARMACOLOGY Mechanism of action Aldactone (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through petitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Aldactone causes increased amounts of sodium and water to be excreted, while potassium is retained.

Aldactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents that act more proximally in the renal tubule. Aldosterone antagonist activity Increased levels of the mineralocorticoid, aldosterone, are present in primary and secondary hyperaldosteronism. Edematous states in which secondary aldosteronism is usually involved include congestive heart failure, hepatic cirrhosis, and nephrotic syndrome. By peting with aldosterone for receptor sites, Aldactone provides effective therapy for the edema and ascites in those conditions. Aldactone counteracts secondary aldosteronism induced by the volume depletion and associated sodium loss caused by active diuretic therapy. Aldactone is effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Aldactone inhibits the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss.

Aldactone has not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. Pharmacokinetics Aldactone is rapidly and extensively metabolized. Sulfur-containing products are the predominant metabolites and are thought to be primarily responsible, together with Aldactone, for the therapeutic effects of the drug. The following pharmacokinetic data were obtained from 12 healthy volunteers following the administration of 100 mg of spironolactone (Aldactone film-coated tablets) daily for 15 days. On the 15th day, spironolactone was given immediately after a low-fat breakfast and blood was drawn thereafter. Aldactone Side Effects Center For Patients Last reviewed on RxList 5/12/2015 Aldactone (spironolactone) is an aldosterone receptor antagonist that causes the kidneys to remove water and sodium from the body, with reduced losses of potassium.

Aldactone is used to reduce edema caused by heart, liver or kidney problems, hypertension, and certain patients with hyperaldosteronism. Aldactone is available in a generic form named spironolactone. mon side effects of Aldactone include skin rash, headache, dizziness, nausea, vomiting, gas, and stomach pain. Tell your doctor if you have serious side effects of Aldactone including irregular heart rate, muscle pain or weakness, urinating less than usual, shallow breathing, tremors, confusion, or a severe skin reaction. Aldactone is available in 25, 50 and 100 mg tablets. Serious side effects of Aldactone include hyperkalemia, altered heart beats, confusion, tremors, decreased or no urine output, shallow breathing, muscle pain or weakness, and numbness. Because of tumor formation in experimental animals, use in pregnancy should be avoided unless the benefits outweigh the potential risks to the fetus women who are breastfeeding are advised not to use Aldactone.

In addition, the drug should not be used to decrease the normal edema of pregnancy. Aldactone has not been proved safe or effective in the pediatric population. Our Aldactone (spironolactone) Side Effects Drug Center provides a prehensive view of available drug information on the potential side effects when taking this medication. This is not a plete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Aldactone in Detail - Patient Information: Side Effects Get emergency medical help if you have any of these signs of an allergic reaction: hives difficulty breathing swelling of your face, lips, tongue, or throat. Stop using spironolactone and call your doctor at once if you have a serious side effect such as: numbness or tingly feeling muscle pain or weakness slow, fast, or uneven heart rate feeling drowsy, restless, or light-headed urinating less than usual or not at all shallow breathing tremors, confusion nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes) or severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

This is not a plete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Read the entire detailed patient monograph for Aldactone (Spironolactone)What is spironolactone (Aldactone) Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body. Spironolactone also treats fluid retention (edema ) in people with congestive heart failure. cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication is also used to treat or prevent hypokalemia (low potassium levels in the blood).

Spironolactone may also be used for purposes not listed in this medication guide./media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-patientcare. jpg / Quality Care Find out why Mayo Clinic is the right place for your health care. Make an appointment. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-docsdepts. jpg / Meet the Staff Find a directory of doctors and departments at all Mayo Clinic campuses. Visit now. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-research. jpg / Research and Clinical Trials See how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care. Explore now. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-meded.

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jpg / Give to Mayo Clinic Help set a new world standard in care for people everywhere. Give now. Generic equivalents for Aldactone . What are Generics A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, how it is taken, performance, and intended use. Before generics bee available on the market, the generic pany must prove it has the same active ingredients as the brand-name and works the same way in the body in the same amount of time. The only differences between generics and their brand-name counterparts is the generics are less expensive and may look slightly different (e. g. different shape or color), as trademark laws prevent a generic from looking exactly like the brand-name drug. Generics are less expensive because generic manufacturers dont have to invest large sums of money to invent a drug. When the brand-name patent expires, generic panies can manufacture a copy of the brand-name drug and sell it at substantial discounts. NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. This page contains answers to some mon questions about Aldactone. It does not contain all the information that is known about Aldactone.

It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. Bookmark or print this page, you may need to read it again.

Aldactone - 100 mg What is Spironolactone Spironolactone is a potassium-sparing diuretic (water pill) that stops the body from absorbing too much salt and keeps the potassium levels from decreasing greatly. It is prescribed for the treatment of hypertension (high blood pressure) as well as to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephritic syndrome. It is also used to treat or prevent hypokalemia or low potassium levels in the blood. Spironolactone is also prescribed for the diagnosis or treatment of a condition in which there is too much aldosterone in the body. Aldosterone is a hormone secreted by the adrenal glands that helps regulate the salt and water balance in the body. Spironolactone is sold under various trade names, one of which is Aldactone (made by RPG Life Sciences). Important Information about Spironolactone Do not take Spironolactone (Aldactone) if you have a known allergy to it, or if you have kidney disease, high levels of potassium in your blood, or if you are unable to urinate. Do not take potassium supplements or other diuretics while you are taking Spironolactone.

Also avoid salt substitutes or low sodium milk products that contain potassium. These products can shoot up your potassium levels while taking this medicine Prior to taking Spironolactone, let your doctor know if you have liver disease, or if you take steroidal medicines or another diuretic. Avoid a high salt diet while taking this medicine. High salt intake will cause your body to retain water and can make this medicine less effective. Do not exert more or bee dehydrated while exercising and while in hot weather. Follow your doctorrsquos directions about the type and amount of liquids you should drink. In some instances, consuming too much liquid can be as harmful as not drinking enough. If you are being treated for high blood pressure, continue taking Spironolactone even if you donrsquot have any symptoms.

High blood pressure doesnrsquot have any outwardly signs. You may have to take this medicine for the rest of your life. Spironolactone is an FDA pregnancy category C drug. It is known that this medicine can harm an unborn baby if taken during pregnancy. Spironolactone can pass into breast milk and harm a nursing baby. Consult your doctor before taking Spironolactone if any of these cases apply to you. Before taking Spironolactone Before taking Spironolactone (Aldactone), take care of all precautions mentioned above. Discuss them with your doctor and clear all doubts which you may have about this drug. How should I take Spironolactone Take Spironolactone strictly according to your doctorrsquos direction or according to the instructions on the medication label.

Do not alter the dosage unless your doctor advises you to do so. Also, do not take this medication after the prescribed period is over. All medications e with a patient leaflet. Refer the instructions in them for detailed information on that particular medication. Always store this medicine in a cool and dry place. What if I miss a dose If you miss a dose of Spironolactone, take it as soon as you remember. Donrsquot take the missed dose if the time to take the next dose is almost up. Taking multiple doses near to each other can lead to excess medication in your body which can be harmful.

What if I overdose In case of an overdose of Spironolactone, get emergency medical attention or call the Doctor Immediately. Overdose may result in drowsiness, confusion, red skin rash, nausea, vomiting, or diarrhea. Things and Activities to avoid while taking Spironolactone Spironolactone may impact your thinking capability and reflexes. Take extra care while driving or other such activities that require a high level of mental awareness and alertness. Do not exert more or bee dehydrated while exercising and while in hot weather. Also, do not take potassium supplements or other diuretics while you are taking Spironolactone. Also avoid salt substitutes or low sodium milk products that contain potassium.

These products can shoot up your potassium levels while taking this medicine Spironolactone Side Effects Some mon side effects of Spironolactone are reduced heart rate, dizziness, nausea, headache, or fatigue. However, if any of these side effects persist or deteriorate, seek medical attention right away. Some serious side effects or allergic reactions due to Spironolactone are rash, itching, swelling of face, tongue, or throat, or breathing trouble, symptoms of high potassium that can be fatal (slow or irregular heartbeat, muscle weakness), unusual fatigue, sudden or unexplained weight gain, increased thirst, change in amount of urine, severe dizziness, muscle spasms, menstrual period changes, breast enlargement in men, sexual function problems, severe stomach or abdominal pain, dark urine, yellowing of eyes and skin, or persistent nausea or vomiting. The side effects mentioned above are not the only ones that you may experience or witness due to Spironolactone.

If you get any serious side effects due to this medication, contact your doctor right away. Spironolactone Dosing Information Spironolactone dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be determined by your doctor after examining you properly. Remember to follow your doctorrsquos advice properly for best results. Interaction with other drugs The following drugs can interact with Spironolactone: lithium, digoxin, steroids, ACE inhibitors, NSAIDs. However, these are not the only drugs that can interact with Spironolactone.

There may be others. Let your doctor know in advance if you use any medicines or related products such as OTC medicines, vitamin pills, or herbal products. Never start a new medication without proper medical advice. Server Error in / Application. Runtime Error Description: An application error occurred on the server. The current custom error settings for this application prevent the details of the application error from being viewed remotely (for security reasons).

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Medical Research - A look at recent progress and developments in the field of health and medicine. About DailyMed DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts). This Web site provides a standard, prehensive, up-to-date, look-up and download resource of medication content and labeling found in medication package inserts.

The National Library of Medicine (NLM) provides this as a public service and does not accept advertisements. The drug labeling information on this Web site is the most recent submitted to the Food and Drug Administration (FDA) and currently in use it may include, for example, strengthened warnings undergoing FDA review or minor editorial changes. These labels have been reformatted to make them easier to read. Brand Name: Aldactone Generic Name: Spironolactone This medicine is a diuretic or water pill.

What does this medicine do Helps the body hold on to potassium, an important mineral in the body. Removes a small amount of extra fluid from the body. How should I give my child this medicine Give at the same time each day as directed. Give with or without food/liquids. Can be given as a liquid or as a pill. The liquid should be measured only with an oral syringe. What should I do if my child vomits after a dose If vomiting occurs within 15 minutes after the medicine is given, give the entire dose again. If more than 15 minutes have passed, do not give it again until the next scheduled dose.

What should I do if my child misses a dose Give the dose up to 2 hours later. If it is more than 2 hours late, skip the missed dose and give the next dose at the regular time. Never try to make up missed doses by giving extra medicine. What precautions or special instructions should I know about Children taking Aldactone and other diuretics can bee easily dehydrated if they have diarrhea or vomiting that lasts more than 24 hours. For babies on diuretics, this can happen even quicker.

Signs of dehydration in children include decreased urine output, dry mouth, lack of tears with crying, and dry skin. In babies, another sign of dehydration is that the soft spot on top of the head bees depressed or sunken. If you notice any of these signs in a child with vomiting or diarrhea, please call your childs doctor right away. What are the mon side effects Side effects are unlikely but report: Muscle weakness Fatigue Tingling hands/feet Enlarged breasts Upset stomach Irregular heartbeat This information does not cover all the uses, precautions, side effects or interactions of this medicine. If you have any further questions, please contact your doctor. 2006: Information reviewed by Lynda Dettling BSN, RNAbout DailyMed DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts). This Web site provides a standard, prehensive, up-to-date, look-up and download resource of medication content and labeling found in medication package inserts.

The National Library of Medicine (NLM) provides this as a public service and does not accept advertisements. The drug labeling information on this Web site is the most recent submitted to the Food and Drug Administration (FDA) and currently in use it may include, for example, strengthened warnings undergoing FDA review or minor editorial changes. These labels have been reformatted to make them easier to read. Aug 24, 2010 (Started Jun 01, 2010) What is spironolactone Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body. Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome.

This medication is also used to treat or prevent hypokalemia (low potassium levels in the blood). Spironolactone may also be used for other purposes not listed in this medication guide. Precautions Do not use this medication if you have: kidney disease or are unable to urinate high potassium levels (hyperkalemia) or if you are taking potassium supplements or other potassium-sparing diuretics such as Aldactazide, amiloride (Midamor, Moduretic), or triamterene (Dyrenium, Dyazide, Maxzide). Before using spironolactone, tell your doctor if you have: heart disease liver disease or if you are using a steroid, or another diuretic. If you have any of these conditions, you may need a dose adjustment or special tests to safely take spironolactone. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to bee pregnant during treatment.

Spironolactone passes into breast milk and could cause harm to a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Avoid drinking alcohol, which can increase some of the side effects of spironolactone. Tell your doctor if you regularly use other medicines that make you light-headed (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to the side effects of spironolactone. Do not use salt substitutes or low-sodium milk products that contain potassium.

These products could cause your potassium levels to get too high while you are taking spironolactone. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. Spironolactone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid being overheated or dehydrated during exercise and in hot weather. Follow your doctors instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Instructions Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include drowsiness, confusion, red skin rash, nausea, vomiting, or diarrhea. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Side Effects Get emergency medical help if you have any of these signs of an allergic reaction: hives difficulty breathing swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects: numbness or tingly feeling muscle pain or weakness slow, fast, or uneven heartbeat feeling drowsy, restless, or light-headed urinating less than usual or not at all shallow breathing tremors, confusion or nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious side effects may include: mild nausea or vomiting dizziness, headache gas, stomach pain or skin rash. This is not a plete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Interactions Before taking this medication, tell your doctor if you are using any of the following drugs: lithium (Eskalith, Lithobid) digoxin (digitalis, Lanoxin) steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik) or an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others. This list is not plete and there may be other drugs that can interact with spironolactone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. SCHEDULING STATUS: PROPRIETARY NAME (and dosage form): ALDACTONE reg 25 TABLETS ALDACTONE reg 100 TABLETS POSITION : ALDACTONE 25: Each tablet contains 25 mg spironolactone ALDACTONE 100: Each tablet contains 100 mg spironolactone PHARMACOLOGICAL CLASSIFICATION: A18.1 Diuretics PHARMACOLOGICAL ACTION: ALDACTONE promotes diuresis in patients with oedema or ascites.

ALDACTONE acts in the distal portion of the renal tubule by petitive inhibition of aldosterone, a sodium-retaining, potassium-excreting hormone. INDICATIONS: Congestive cardiac failure, hepatic cirrhosis with ascites and oedema, the nephrotic syndrome, idiopathic oedema including premenstrual oedema, malignant ascites, essential hypertension, pre-operative management of primary aldosteronism, long-term treatment of primary aldosteronism where the patient is unable or unwilling to undergo surgery, as an aid to the diagnosis of mineralocorticoid excess, including primary aldosteronism. CONTRA-INDICATIONS: ALDACTONE should not be given in acute renal insufficiency, rapidly progressing impairment of renal function, anuria or hyperkalaemia. Administration is not remended in the presence of a raised serum potassium and the conitant use of triamterene or amiloride should be avoided as hyperkalaemia may be induced. The use of potassium supplements is also not remended for the same reason except in cases of initial potassium depletion. DOSAGE AND DIRECTIONS FOR USE: Adults:- Congestive heart failure, hepatic cirrhosis with ascites and oedema, idiopathic oedema including premenstrual oedema, the nephrotic syndrome, malignant ascites.

The usual dosage is 100 - 200 mg/day, (usually in association with a conventional diuretic). Essential hypertension . the usual dosage is 100 mg/day. A higher dosage may be used it necessary. Primary aldosteronism and other forms of hypertension associated with low plasma renin. a) Pre-operative management 100 - 400 mg/day for 3 - 5 weeks before operation. b) Long-term management Where operative correction of primary aldosteronism is not desirable, or possible, 200 - 400 mg/day frequently normalises blood pressure and electrolyte abnormalities.

The smallest dose which achieves the desired effect should be used. c) Screening for mineralocorticoid excess including primary aldosteronism. Mineralocorticoid excess may be detected by using 300 - 400 mg daily in divided doses in conjunction with in-vivo faecal dialysis, or rectal electrical potential measurements. Tests based on changes in serum potassium, and serum and urinary potassium have also been described. Children:- The remended dosage is 3 mg/kg body weight daily. ALDACTONE is insoluble in water but the tablets may be crushed and given in suspension if necessary. SIDE EFFECTS AND SPECIAL PRECAUTIONS: Gastro-intestinal intolerance, drowsiness and mental confusion have been observed.

Reversible unilateral or bilateral gynaeastia may occur. A maculopapular or erythematous cutaneous eruption has been reported. There have been rare reports of mild androgenicity, hirsutism and menstrual irregularity. Hyponatraemia may occur, especially with intense treatment in bination with conventional diuretics. Potentiation of the action of other anti-hypertensive drugs occurs. Caution should be observed in the presence of liver disease as hepatic a may be precipitated in susceptible subjects.

As with all diuretic therapy, periodic estimation of serum electrolytes may be desirable. KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: True toxic effects have not been reported in overdosage. Hyperkalaemia may be manifested clinically by paraesthesia, weakness, flaccid paralysis or muscle spasm, and may be difficult to distinguish clinically from hypokalaemia. Electrocardiographic changes give the earliest indications of pathologically disturbed serum potassium levels. In the event of hyperkalaemia, discontinue the drug, reduce potassium intake and administer potassium-excreting diuretics and intravenous glucose with insulin or an oral ion-exchange resin as appropriate. IDENTIFICATION: ALDACTONE 25: 8,8 mm diameter, white, biconvex tablets stamped, SEARLE above 39 on one side. ALDACTONE 100: 11,1 mm diameter, white biconvex tablets stamped, SEARLE above 134 on one side. PRESENTATION: ALDACTONE 25: Bottles containing 60 or 200 tablets. ALDACTONE 100: Bottles containing 30 or 60 tablets.

STORAGE INSTRUCTIONS: Store in a dry place below 25176C. Keep out of reach of children. REGISTRATION/REFERENCE NUMBERS: NAME AND BUSINESS ADDRESS OF THE APPLICANT: G. D. Searle (South Africa) (Pty) Ltd.,

Sleeping Or Cuddling After Sex What It Might Mean For Your Relationship

Sleeping Or Cuddling After Sex What It Might Mean For Your RelationshipSleeping Or Cuddling After Sex What It Might Mean For Your Relationship Jan 23, 2012 Emma Gray Executive Womens Editor, The Huffington Post Science has finally proven that pillow talk isnt just for women. However, when you fall asleep first, it may mean something different than when your male partner does. A new study from the University of Michigan and Albright College in Pennsylvania found that nodding off first could make your partner want to cuddle even more, according to a press release published on ScienceDaily. Daniel ger, the studys lead author and a research fellow at the University of Michigan explained: The more ones partner was likely to fall asleep after sex, the stronger the desire for bonding. And get this: Of the 456 study participants. women and men were equally as likely to pass out first.

The research, published in the December 2011 issue of the Journal of Social, Evolutionary and Cultural Pyschology . analyzed data from online surveys that asked participants about their post-sex sleep habits as well as their desires surroundingmunication and affection. Most of the partners who didnt drop off so easily expressed a stronger penchant for cuddling and conversation after sex. The researchers also found that being the first to fall asleep may leave your partner wanting more in the morning, but it could also mean that youre unconsciously trying to avoid a conversation relating tomitment. The researchers asserted that men may avoid these conversations because women tend to have better verbal abilities. and therefore an upper hand in discussions about the future of a relationship.

If men actively avoidmitment promises in post-coital conversation, this could increase the likelihood of women ending the relationship. Hastening sleep onset may evade this adverse effect, wrote the researchers. Women also tended to find sleeping with a partner after sex to be more important than men did, and were more likely to fall asleep first when going to bed with a partner without having sex. Perhaps men stay awake longer. making sure the woman doesnt leave them for another partner, Susan Hughes, co-author of the study, told ScienceDaily. Men may also stay awake longer in an attempt to entice their partner into having sex. Alas, you cant always get what you want -- sometimes a woman just needs some shut-eye.

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