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Rather, it is a non-bacteriostatic sulfonamide possessing a chemical scture and pharmacological activity distinctly different from the bacteriostatic sulfonamides. Diamox is an enzyme inhibitor that acts specifically on carbonic anhydrase, the enzyme that catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In the eye, this inhibitory action of acetazolamide decreases the secretion of aqueous humor and results in a drop in intraocular pressure, a reaction considered desirable in cases of glaa and even in certain non-glaatous conditions. Evidence seems to indicate that Diamox has utility as an adjuvant in treatment of certain dysfunctions of the central nervous system (e. g. epilepsy).

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INDICATIONS AND USAGE: For adjunctive treatment of: chronic simple (open-angle) glaa, secondary glaa, and preoperatively in acute angleclosure glaa where delay of surgery is desired in order to lower intraocular pressure. Diamox is also indicated for the prevention or amelioration of symptoms associated with acute mountain sickness despite gradual ascent. CONTRAINDICATIONS: Hypersensitivity to acetazolamide or any excipients in the formulation. Since acetazolamide is a sulfonamide derivative, cross sensitivity between acetazolamide, sulfonamides and other sulfonamide derivatives is possible. Acetazolamide therapy is contraindicated in situations in which sodium and/or potassium blood sm levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. It is contraindicated in patients with cirrhosis because of the risk of development of hepatic encephalopathy. Long-term administration of Diamox is contraindicated in patients with chronic non-congestive angle-closure glaa since it may permitanic closure of the angle to occur while the worsening glaa is masked by lowered intraocular pressure.

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There are no adequate and well-controlled studies in pregnant women. Acetazolamide should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Nursing Mothers Because of the potential for serious adverse reactions in nursing infants from Diamox, a decision should be made whether to discontinue nursing or to discontinue the g taking into account the importance of the g to the mother. Acetazolamide should only be used by nursing women if the potential benefit justifies the potential risk to the child.

Pediatric Use The safety and effectiveness of Diamox SEQUELS in pediatric patients below the age of 12 years have not been established. Growth retardation has been reported in children receiving long-term therapy, believed secondary to chronic acidosis. Geriatric Use Metabolic acidosis, which can be severe, may occur in the elderly with reduced renal function. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and coitant disease or other g therapy. ADVERSE REACTIONS: Body as a whole: Headache, malaise, fatigue, fever, pain at injection site, flushing, growth retardation in children, flaccid paralysis, anaphylaxis. Digestive: Hematological/Lymphatic: Blood dyscrasias such as aplastic anemia, agranulocytosis, leukopenia, thrombocytopenic purpura, melena. Hepato-biliary disorders: Abnormal liver function, cholestatic jaundice, hepatic insufficiency, fulminant hepatic necrosis. Metabolic/Nutritional: Metabolic acidosis, electrolyte imbalance, including hypokalemia, hyponatremia, osteomalacia with long-term phenytoin therapy, loss of appetite, taste alteration, hyper/hypoglycemia. Drowsiness, paresthesia (including numbness and tingling of extremities and face), depression, excitement, ataxia, confusion, convulsions, dizziness.

Allergic skin reactions including urticaria, photosensitivity, Stevens - Johnson syndrome, toxic epidermal necrolysis. Special senses: Hearing disturbances, tinnitus, transient myopia. Urogenital: Crystalluria, increased risk of nephrolithiasis with long-term therapy, hematuria, glycosuria, renal failure, polyuria. OVERDOSAGE: No specific antidote is known. Treatment should be symptomatic and supportive. Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur. Sm electrolyte levels (particularly potassium) and blood pH levels should be monitored.

Supportive measures are required to restore electrolyte and pH balance. The acidotic state can usually be corrected by the administration of bicarbonate. Despite its high intraerythrocytic distribution and plasma protein binding properties, Diamox may be dialyzable. This may be particularly important in the management of Diamox overdosage whenplicated by the presence of renal failure. DOSAGE AND ADMINISTRATION: The rmended dosage is 1 capsule (500 mg) two times a day. Usually 1 capsule is administered in the morning and 1 capsule in the evening. It may be necessary to adjust the dose, but it has usually been found that dosage in excess of 2 capsules (1 g) does not produce an increased effect. The dosage should be adjusted with careful individual attention both to symptomatology and intraocular tension. In all cases, continuous supervision by a physician is advisable.

In those unusual instances where adequate control is not obtained by the twice-a-day administration of Diamox SEQUELS, the desired control may be established by means of Diamox (tablets or parenteral). Use tablets or parenteral in accordance with the more frequent dosage schedules rmended for these dosage forms, such as 250 mg every four hours, or an initial dose of 500 mg followed by 250 mg or 125 mg every four hours, depending on the case in question. Acute Mountain Sickness Dosage is 500 mg to 1000 mg daily, in divided doses using tablets or extended-release capsules as appropriate. In circumstances of rapid ascent, such as in rescue or military operations, the higher dose level of 1000 mg is rmended. It is preferable to initiate dosing 24 to 48 hours before ascent and to continue for 48 hours while at high altitude, or longer as necessary to control symptoms. HOW SUPPLIED: Diamox reg SEQUELS reg (Acetazolamide Extended-Release Capsules) are available as 500 mg: Orange opaque cap and orange opaque body filled with white to off-white pellets. Imprinted in black ink, Diamox 754 .

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Gplc (Glycine Propionyl L-Carnitine)GPLC (glycine propionyl l-carnitine) What is GPLC Glycine Propionyl L-Carnitine: GPLC is an exciting new supplement that heralds a potential breakthrough in the treatment of cardiovascular problems, such as heart attacks, angina and myocardial ischemia insufficient blood supply to the heart muscle. Not only that but this ground-breaking product is also proving to be particularly beneficial for those who exercise vigorously as it helps boost energy levels. There is also evidence that it is effective in the area of sexual dysfunction and can help men improve their sexual performance The name of this incredible supplement is Glycine Propionyl L-Carnitine (gPLC) a new, super-charged form of the established supplement carnitine. Carnitine provides energy and helps remove harmful toxins from your cells In order to understand how gPLC works it is important to know more about carnitine and its role in the body first. Carnitine is similar to, and closely related to, an amino acid. Your body manufactures it in your liver, with the aid of iron and the vitamins C, B3 and B6. It is also available from dietary sources and is present in meat, dairy products and avocados.

Tissues in your heart, liver and muscles are reliant on carnitine to transport fatty acids into the mitochondria the power stations within your cells (a typical heart muscle contains 5,000 mitochondria) so that energy can be produced for use by your body. Fatty acid metabolism (the production of energy from food) is responsible for between 60 and 70 per cent of the energy generated in the cells of your heart and the lining of your arteries. Fatty acids yield higher levels of ATP (adenosine triphosphate your bodys main energy storagepound) than glucose does. While one glucose molecule can yield 38 ATP molecules, one molecule of fat can yield more than three times as much (namely 129 molecules of ATP). In effect, fatty acids are your hearts high-energy fuel. Your cells cant store all the ATP that they need, so they have to have a continuous turnover. Your heart, for example, must have a constant supply of ATP and carnitine helps with this process.

While carnitine acts as a sort of shuttle service which carries fatty acids across the membrane of the mitochondria, it also acts in the opposite direction as a vehicle for helping to remove toxic waste products from the mitochondria. How is gPLC more effective than carnitine for promoting optimal heart health The supplement gPLC has been shown to improve heart function even better than normal carnitine as it contains both PLC (Propionyl-L-Carnitine) a form of carnitine produced in your body which has a special affinity for cells within the heart muscle and blood vessels and glycine (an amino acid which is used to promote muscle health). As a result gPLC ensures optimal heart energy production and it is also better absorbed than ordinary carnitine. The benefits of carnitine and in particular its new supercharged form gPLC have been championed in the US by leading cardiologist Dr Stephen Sinatra. His research suggests that when gPLC is taken following a heart attack energy levels increase. In addition, gPLC appears to prevent damage in the cells of the heart muscle caused by a lactic acid build-up such a build-up occurs during a heart attack. According to Dr Sinatra, it can improve your chances of surviving a heart attack and indeed animal studies have shown that it can increase the ability to survive a series of heart attacks. Most heart attack damage occurs in the left ventricle if this increases in size after an attack, this is often an indicator that there will be further problems.

The promising news is that a randomised, placebo-controlled study, involving 30 heart failure patients, has shown that gPLC led to a small but significant decrease in left ventricular size and also improved the patients ability to tolerate exercise. In addition, a randomised, double blind, placebo-controlled study involving more than 500 people over a period of six months also suggests that the supplement helps to improve exercise tolerance in heart failure patients. Benefits everyone from athletes to sufferers of intermittent claudication and erectile dysfunction gPLC can also help people without heart problems improve their exercise tolerance. Obviously, a heart whose cells are efficiently producing optimal energy is best able to pump blood efficiently around the body, enabling it to cope better under strain, such as during exercise.

Additional Information: In addition to encouraging this healthy functioning of the heart, gPLC also promotes fatty acid metabolism in other muscles, making it especially beneficial to athletes and those involved in rigorous exercise since such activities rely on the use of fatty acids as a major source of fuel. gPLC can be helpful to athletes since it facilitates the creation of energy that is being used up at a higher than normal rate. In addition, gPLCs beneficial effect on peripheral muscles makes it more efficient than ordinary carnitine in improving the symptoms of intermittent claudication a peripheral arterial disease, whereby diminished blood flow to the legs can result in pain when exercising. A randomised placebo-controlled study involving 495 patients with intermittent claudication suggests that gPLC can significantly increase the maximum distance that such patients can walk without difort. Male Potency: On top of all this, there appears to be an added bonus attached to gPLC in the area of male potency and sexual performance. One study showed that abination of gPLC and Acetyl-L-Carnitine (another form of carnitine) was as good as testosterone in the treatment of erectile dysfunction, and further studies have shown gPLC to be helpful in potentiating the action of Viagra. What to take for best results The rmended dosage amount is one gPLC tablet taken each day in between meals with juice or water, or as otherwise directed by your healthcare practitioner.

While there are no known contraindications attached to gPLC, you should consult your doctor before taking it, especially if you are currently on any medication. It should not be taken as a substitute for a prescribed medicine or remedy. BEST SELLER: Jarrows GPLC STAFF PICK: Doctors Bests GPLC

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