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Maldives Joins The International Rowing FederationMaldives joins the International Rowing Federation The Maldives has been weed as the 131st member of the International Rowing Federation (FISA), following the associations congress in New Zealand. The landmark membershipes as British Olympic rower Guin Batten returned to the Maldives last week with a team of four champion female rowers, to try and break the record she set for crossing the equator between Huvadhoo Atoll and Fuahmulah in March. Batten crossed the 60 kilometre zero degree channel in seven hours 16 minutes, in an epic sggle against the the swells, tides and currents of the open Indian Ocean in her 35 kilogram rowing boat. The 42 year-old silver medallist, who also holds the world record for her solo row across the English Channel, attempted the crossing again together with elite rowers Rachel Woolf, Ali Gill, Elise Cope and Louise Wymer. The aim, says Batten, was to trash my record for the single crossing, in a quad (four rowers, one coxswain). Unfortunately the weather against us. We started quickly, and might have managed it in 5.5 hours, but we were not fast enough for currents and it began to look like it would take us 15 hours 8211 which meant the support vessel was going ton out of fuel, she says.

The team had trained for an endurance slog, but the brief window in the weather had closed and conditions rapidly began to deteriorate and the attempt was reluctantly called off after three hours. But the record is still there for the taking, and theres a good chance somebody local could break my time of 7:16, Batten says. Batten may keep her title for the meantime, but the main purpose of the visit was to inspire local islanders 8211 particularly women 8211 to pick up the oar and re-embrace the countrys traditional mode of transport. Acting as the Sports Development Coordinator for Friends of Maldives (FOM), Batten arranged for two four-person quad rowboats to be brought to the Maldives, with the support of British Airways (BA), British Rowing and Westminster School.

Meanwhile, the mission to reintroduce rowing to the country has been ticking away ever since Batten left her rowboat behind following her attempt in March. Primary school teacher and coastal rower James Cowley has been working as a volunteer based in Thinadhoo to develop the sport of rowing in the Maldives, and has already established the Rowing Association of the Maldives: I believe its the first national sporting association to be based outside Male, Batten says. Cowley told World Rowing in October that getting appropriate equipment to the country remained a key challenge for the project: It is amazing how much the young people have learnt using only Guins rowing boat, a canoe and the goggles Speedo sent out last month, he said. The equipment problem was been somewhat addressed with Battens latest visit, but other challenges remain: For starters, a lot of people here dont swim, which was quite surprising, so James taught 30 young people to swim and got them rowing in the lagoon while they developed safety procedures.

Currently Cowley is training a group of male rowers and some younger men, as well as four girls who are facing a lot of pressure because James is a male coach, Batten says. Elise Cope will spend three weeks coaching, but we need to have a female coach based out here too.8221 Rowing, she notes, 8220is one of the fastest growing sports for women worldwide8221, andan art not entirely lost to the Maldives, 8220but most of the people who know how to do it are in their 60s, and theres a risk the knowledge will be lost with this generation, says Batten. Despite the challenges locals have really taken to the project, and the arrival of the new boats will get many more out onto the water. Saad Ibrahim, representing the Rowing Association of the Maldives, observes that the boat allows us to take multiple young rowers out at the same time so they can learn to row together and develop their team skills. Batten describes it as a fantastic opportunity to bring rowing back to the Maldivianmunity. The vision for this long term initiative is to bring sport into themunity to encourage life skills such as team work amongst the local people and to give them the chance to see more of their surroundings. Locally, the projects ambition is to set up six water sports clubs throughout the Upper Southern Province. Ultimately, Batten says, the Maldives may one day look to host the World Coastal Rowing Championships, which will introduce a lot of people to the country who would not normally visit otherwise 8211 its quite a different group of people to the surfing and divingmunity, she adds. Likes ( 0 ) Dislikes ( 0 )

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Dorzox TDorzolamide, Timolol Maleate Description Dorzox Eye Drops (Dorzolamide) is used to treat intraocular pressure in patients with ocular hypertension or glaua. It is used by patients specifically in order to manage and alleviate the associated symptoms. Dosage and Administration Dorzox Eye Drops (Dorzolamide) are administered in the same way that most eye drops are. Patients prescribed this medication will usually be instructed to dispense 1 droplet into each affected eye, between 1 and 3 times each day. Immediately after applying the required eye drops, close the eye for 1 to 2 minutes to help the medicine distribute at the same time as applying gentle pressure to the inside corner of the eye. Dorzox Eye Drops (Dorzolamide) are usually very well tolerated and any side effects are only mild and short-lasting, however any you notice should be reported to your physician. Possible side effects include: Irritation Burning Stinging Dryness Blurry vision Increased sensitivity to lightDorzox-T Eye Drops - Uses, position, Dosage, Side Effects amp Reviews Dorzox-T is considered safe for the treatment of open angle glaua which reduces the intraocular pressure to cure the problem. This medication also cures ocular hypertension. This drug contains two ponents which are dorzolamide and timolol. These both work together to decrease the elevated intraocular pressure by reducing the aqueous humor secretion.

The higher the level of intraocular pressure, the greater the likelihood of glauatous field loss and optic nerve damage. The bined effect of these two agents administered as dorzolamide-timolol fixed dose bination resulting in additional intraocular pressure reduction. Now save your gradually decreasing vision due to open angle glaua with the use of Dorzox-T. Buy it online at discounted prices from us. Dorzox-T Eye Drops Uses Dorzolamide . It acts as an inhibitor of human carbonic anhydrase II. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol . It acts as adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant or local anesthetic activity. Dorzox-T Eye Drops position Dorzolamidehelliphelliphelliphelliphelliphelliphellip.

.2 w/v Timololhelliphelliphelliphelliphelliphelliphelliphelliphellip. 0.5 w/v Benzalkonium Chloridehelliphellip. 0.0075 w/v Dorzox-T Eye Drops Dosage The remended dose is one drop in the affected eye two times daily. If more than one topical ophthalmic drug is being used, the drugs should be administered ten minutes apart. Please consult your doctor and follow his or her remendations. Please do not self medicate. Dorzox-T Eye Drops Side Effects The side effects are the negative response of a drug or a medical treatment on your body. The mon side effects which can occur after taking this medicine are unusual taste, ocular burning, stinging, conjunctival hyperemia, blurred vision, eye itching, superficial punctate keratitis, abdominal pain, back pain, corneal erosion, corneal staining, eye debris, eye discharge, eye discharge, eye pain, eyelid edema, headache, hypertension, influenza, lens nucleus coloration, lens opacity, nausea, nuclear lens opacity, pharyngitis, sinusitis, upper respiratory infection, urinary tract infection, visual field defect and vitreous detachment.

Consult your doctor in case any of these side effects bother you. Other Information on Dorzox-T Eye Drops:Dorzox T - 5 ml Eye Drop Dorzox T Eye Drop What is Dorzolamide Hydrochloride - Timolol Maleate Dorzolamide Hydrochloride - Timolol Maleate is a bination eye care medication having two active ingredients namely Dorzolamide Hydrochloride and Timolol Maleate. Dorzolamide Hydrochloride reduces the amount of fluid in the eye that lowers pressure inside the eye. Timolol Maleate is a beta blocker that also lowers eye pressure. High intraocular pressure or IOP (fluid pressure inside the eye) is a major risk factor for glaua. Dorzolamide Hydrochloride - Timolol Maleate is mainly prescribed for the treatment of some types of glaua and other causes of high IOP. Dorzolamide Hydrochloride - Timolol Maleate is sold under various trade names, some of which are Cosopt and Dorzox T (made by Cipla). Important Information about Dorzolamide Hydrochloride - Timolol Maleate Do not use Dorzolamide Hydrochloride - Timolol Maleate if you have a known allergy to Dorzolamide Hydrochloride or Timolol Maleate, or if you have a history of asthma, COPD, or a serious heart condition such as AV block slow heartbeats, or if you recently had a heart attack. Also, before using this medication, inform your doctor if you are allergic to any other drugs, or if you have narrow angle glaua, diabetes, kidney or liver disease, or a thyroid disorder. This will enable your doctor to judge whether this medication is safe for you. Do not put any other eye drops into your eyes unless or otherwise advised by your doctor.

Allow at least 10 minutes between two different types of eye drops if you must use two eye drops. Dorzolamide Hydrochloride - Timolol Maleate can cause blurred vision temporarily. Be extra careful while driving or doing anything which requires a high level of vision clarity. Dorzolamide Hydrochloride - Timolol Maleate is a FDA pregnancy category C drug. It is not known if this medication can harm an unborn baby if it is used while being pregnant.

It is also not known whether it can pass into breast milk and harm a nursing baby. Notify your doctor in advance if you are pregnant, planning to bee pregnant, or breast feeding a baby. Before using Dorzolamide Hydrochloride - Timolol Maleate Before taking Dorzolamide Hydrochloride - Timolol Maleate (Cosopt, Dorzox T), take care of all precautions mentioned above and discuss them with your doctor. How should I use Dorzolamide Hydrochloride - Timolol Maleate Use Dorzolamide Hydrochloride - Timolol Maleate (Cosopt, Dorzox T) strictly according to your doctorrsquos direction or according to the instructions on the medication label. Do not alter the dosage unless your doctor advises you to do so. Do not put Dorzolamide Hydrochloride - Timolol Maleate eye drops while you are wearing contact lenses. This medication may have a preservative ingredient which can be absorbed into the soft contact lenses.

Ensure a gap of at least 15 minutes after putting the eye drops before you wear your contact lenses. Ensure a high degree of hygiene while handling Opthalmic drops as chances of contamination are high. Avoid touching the tip of the medication bottle or dropper as well as protect it from contact with any surface. Put the Dorzolamide Hydrochloride - Timolol Maleate drops as advised by your doctor or as mentioned in the instructions. Putting an eye drop is quite simple and doesnrsquot require much assistance. Always store Dorzolamide Hydrochloride - Timolol Maleate in a cool and dark place. Keep the bottle tightly closed when not in use. What if I forgot to take a dose of Dorzolamide Hydrochloride - Timolol Maleate Opthalmic Do not miss a single dose of Dorzolamide Hydrochloride - Timolol Maleate Opthalmic. However, if you miss a dose, take it as soon as your remember it. Do not take the missed dose if the time to take the next dose is almost up. Instead continue with the original schedule.

Never take multiple doses closer to each other. What to do in case of an Overdose An overdose of Dorzolamide Hydrochloride - Timolol Maleate is not expected to cause any serious effects. However, if you think that you have overdosed on this medication, seek medical attention right away or call the Doctor immetiately. Things and Activities to avoid while using Dorzolamide Hydrochloride - Timolol Maleate Dorzolamide Hydrochloride - Timolol Maleate may cause blurred vision for sometime after putting it in your eyes. Do not indulge in any activities that require alertness and proper vision such as driving. Do not use other eye drops while using Dorzolamide Hydrochloride - Timolol Maleate ophthalmic solution unless or otherwise advised by your doctor. But leave a gap of at least 10 minutes between two types of eye drops. Side Effects due to Dorzolamide Hydrochloride - Timolol Maleate Some mon side effects of Dorzolamide Hydrochloride - Timolol Maleate drops (Cosopt, Dorzox T) are blurred vision, double vision, dropping eyelid, burning or stinging in eye, bitter or unusual taste in your mouth, dry eyes, feeling like something is in your eyes, nausea, or headache. If any of these side effects donrsquot subside after sometime or deteriorate, stop using Dorzolamide Hydrochloride - Timolol Maleate and seek immediate medical help.

Some serious but rare side effects of Dorzolamide Hydrochloride - Timolol Maleate are swelling or redness in the eye, eye disfort, sensitivity to light, drainage oozing or crusting of your eyes or eye lids, or signs of infection (fever, chills, sore throat). These are not all the possible side effects due to Dorzolamide Hydrochloride - Timolol Maleate Opthalmic. There may be others. If you experience any serious side effects, stop using this medication and get emergency medical attention. Dorzolamide Hydrochloride - Timolol Maleate Dosing Information Interaction with other drugsDorzox T - 5 ml Eye Drop Dorzolamide is a carbonic anhydrase inhibitor and is a mon medicine given in the treatment of glaua. This medicine is remended by the doctor for the treatment of glaua. Timolol maleate is a beta blocker that reduces the pressure inside the eyes. It was the first beta blocker approved for the topical use. It helps to reduce the elevated intraocular pressure which is a main reason behind glaua. Both the drugs help in reducing the elevated intraocular pressure and also decrease the concentration of aqueous humor in the eye. They are prescribed to treat glaua and other pressure conditions.

Dorzolamide and Timolol maleate bination is available on our website in ophthalmic eye drop dosage from. These eye drops are made up of sterile, isotonic and buffered solution with preservative in it. The ailments it is used for . Dorzolamide and Timolol is a potent drug that aims to reduce the intraocular pressure in open angle glaua and ocular hypertension. Understanding the drug Dorzolamide and Timolol: Dorzolamide and Timolol is a potent sterile drug that is used to treat open angle glaua and ocular hypertension. How it works Dorzolamide It is highly specific non petitive carbonic anhydrase inhibitor that slows down the ciliary processes of the eye and decreases aqueous humor secretion. It reduces the sodium and fluid transport and decreases the intraocular pressure.

This way, it treats the elevated intra ocular pressure represents a major risk factor of glaua. Timolol Maleate It is a beta blocker drug that acts by blocking beta receptors. This also lowers the increased intraocular pressure in the eyes. This increased intraocular pressure can cause optic nerve damage and glaua. bination This bination produces additional reduction in intraocular pressure as pared to either drug alone. When should you avoid it You should not take Dorzolamide and Timolol if you: Are allergic to Dorzolamide and Timolol Ever had eye surgery to replace or remove the lens Wear contact lenses or use eye drops Are suffering from severe kidney problems Have narrow angle glaua are pregnant or planning to conceive are breast feeding How much to apply The remended dosage is one drop in the affected eye twice a day. Always take the medicine as prescribed by the Doctor. What are the strengths available Dorzolamide and Timolol bination is available in following strength bination on our website: Who is the manufacturer Dorzox T is manufactured by Cipla Pharmaceuticals private limited, a pharmaceutical giant and is available on our website in the 1, 3 and 6 eye drops. How to apply Dorzolamide and Timolol bination is instilled exactly as prescribed by your doctor.

The general way of using eye drops are as follows: Always wash your hands before using the eye drops Bend your head backward and pull down your eyelid down Hold the dropper above one eye Let go the eyelid and keep the eye closed for 2 to 3 minutes Repeat the procedure for second eye Never ever use eye drops when you are wearing contact lenses Donrsquot touch the eye dropper with your hands, eyes and eyelids When to apply One drop is instilled in the affected eyes twice a day. Always apply the medicine at the same time daily as it reduces the chances of missing a dose. For how long should it be applied Keep on using the medicine as long as remended by the Doctor. It does not cure the root cause of the problem. So, always ask the doctor before stopping its use. What if you apply too much (overdose) In this type of dosage form, there are less chances of overdose. If overdose, immediately consult with your concerned doctor. Few symptoms of overdose are as listed below: Breath shortness Muscular pain Wheezing Chest pain Seizures Bradycardia What if you miss the dose Try to apply the medicine at the same time each day this reduces the chances of missing dose.

Talk to your Doctor if you miss the dose. Donrsquot double up the dose in order to pensate with the previous one. What are the side effects Every medicine shows some side effects, same way this drug also have some undesired effects with it. Dorzolamide and Timolol show mon and serious side effects such as: Blurred vision Eyelid redness Darken eye lashes Thickening of eye lashes Some serious and rare side effects that need serious consideration are stated below: Bitter taste in mouth Changes in vision Irritated eye lids Dizziness Nausea Flashes of light Breath shortness Swelling, rapid weight gain Skin Rashes Are there any possible drug interactions Always inform your doctor about the drugs you are taking till date. Give a plete list of prescription or non prescription drugs and any other disease conditions. This way, doctor is able to decide and give you the list of drugs and other things that may interact with Dorzolamide and Timolol. What are the things to be taken care of Always take the medicine as per prescription Donrsquot use the expired eye drops Donrsquot share your eye drops with anyone or donrsquot use anyonersquos else eye drops This medicine is for ocular use only.

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CloudFlare Ray ID: 26bd4d4f664a291a Your IP. Performance amp security by CloudFlareDorzox T is considered as one of the best medication for the management of ocular hypertension or glaua. This medication works by curing the intraocular pressure of the eye happens in glaua. Increased intraocular pressure is very dangerous for your that may lead to damage of the optic nerve of the eye, which is responsible for our vision. Damage of optic nerve causes blindness. You can buy Dorzox T online from our reliable pharmacy drugspillsmart or from your nearest chemist at a reasonable price. Dorzolamide Hydrochloride-Timolol Maleate Buy Dorzox T Eye Drops Generic (Dorzolamide/Timolol) Dorzox T 5 Eye Drops online Dorzon T contains two drugs that effectively lower down the high pressure inside the eye and prevent blindness. Further, the drug is also helpful for lessening the amount of fluid inside the eye to maintain the correct balance.

You can purchase this medication from our online pharmaceutical store for the treatment of increased pressure in the eye, wide-angle glaua What is the correct usage of this drug It is important to carefully read all the specifications ad instruction given in the leaflet that es with this medication before start using it and each time you get a refill. For detailed information, you can also contact your doctor or pharmacist. What are the possible side effects that may occur while using the medicationDescription Dorzox T 5ml Eye Drop Dorzox T eye drops are used to treat intraocular pressure in the patients who are either suffering from glaua or ocular hypertension. Regular usage of this medicine helps manage and alleviate the symptoms, thus bringing in relief. How it works Dorzolamide Hydrochloride present in Dorzox T eye drops reduces the amount of fluid in the eyes and an immediate result of this is that the eye pressure es down.

On the other hand, Timolol Maleate provides relief from the symptoms of glaua and high intraocular pressure. Important information about Medicine Dorzolamide Hydrochloride-Timolol Maleate, this bination acts as a carbonic anhydrase inhibitor. Dorzox T eye drops work by lowering down pressure in the eyes which prevents gradual vision loss. Regular intake tends to control the signs and symptoms of glaua.

Dosage information Dorzox T eye drops need to be used thrice a day or as directed by the doctor. The doctor would decide on both the dosage and length of treatment looking at the condition of the patient and response ing from the medicine. Strengths available Dorzox T eye drops are available in the strength of 5ml on our website. What if you miss a dose Try to take every dose on time, in case you miss one and find that the time to next dose is not near you can take on the missed one. What if you overdose In case, you feel that you have taken an extra dose, consult with your doctor and seek medical assistance.

Things to be taken care of Dorzox T eye drops are to be used strictly under a doctorrsquos instructions and make sure that you maintain plete hygiene while using this. Do not put the eye drops on contact lenses and maintain a time gap of at least 15-20 minutes before you wear lenses. Try not to indulge in the activities that would put stress on the eyes or require alertness. Always maintain a time gap of 10-15 minutes when putting Dorzox T eye drops in both eyes. No major side effects of Dorzox T eye drops have been reported so far, however the minor to moderate ones that would bother some and not all are: Double vision Blurred vision Burning or stinging in eye Dropping eyelid Bitter or unusual taste in your mouth Headache Nausea Sensitivity to light Crusting of your eyes or eye lids Redness in the eye Swelling in the eye If you feel unfortable using Dorzox T eye drops go and consult your doctor immediately. Interaction with other drugs The constituents present in Dorzox T eye drops might interact with oral beta blockers, calcium channel blockers, anti-depressants and oral carbonic anhydrase inhibitors.

Make sure that you inform your doctor about the medicines that you are taking and do not start taking any new medicine while using Dorzox T eye drops. Dorzox, Dorzox T, Cosopt To meet the diverse requirements of our clients, we are offering superior quality Dorzox, Dorzox T, Cosopt (Dorzolamide and Timolol Eye Drops). Our offered eye drops are used to treat increased pressure in the eye caused by open-angle glaua. These eye drops are tested at laboratories in order to dispatch a quality assured range from our side. Offered eye drops are best to treat eye conditions, including glaua and ocular hypertension, in which increased pressure can lead to a gradual loss of vision. Description DORZOX-T ophthalmic solution is prised of two ponents: dorzolamide hydrochloride and timolol maleate.

Each of these two ponents decreases elevated intraocular pressure, whether or not associated with glaua, by reducing the aqueous humour secretion. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glauatous visual field loss. The higher the level of intraocular pressure, the greater the likelihood of glauatous field loss and optic nerve damage. Pharmacodynamics DORZOX-T is prised of two ponents: dorzolamide hydrochloride and timolol maleate. Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase-II. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humour secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anaesthetic (membrane-stabilizing) activity. The bined effect of these two agents administered as dorzolamide-timolol fixed dose bination ophthalmic solution b. i.d. results in additional intraocular pressure reduction pared to either ponent administered alone, but the reduction is not as much as when dorzolamide t. i.d. and timolol b. i.d. are administered conitantly. This medicinal product reduces intra-ocular pressure without the mon side effects of miotics such as night blindness, acmodative spasm and pupillary constriction. Pharmacokinetics Dorzolamide Hydrochloride Indications Dosage and Administration Contraindications Reactive airway disease Bronchial asthma A history of bronchial asthma Severe chronic obstructive pulmonary disease Sinus bradycardia Sino-atrial block Second or third degree atrioventricular block not controlled with the pacemaker Overt cardiac failure Cardiogenic shock Severe renal impairment (CrCl Hypersensitivity to any ponent of this product Warnings and Precautions While taking beta-blockers, patients with a history of atopy or a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated accidental, diagnostic or therapeutic challenge with such allergens.

Such patients may be unresponsive to the usual doses of epinephrine used to treat anaphylactic reactions. In clinical studies, local ocular adverse effects, primarily conjunctivitis and lid reactions, were reported with chronic administration of dorzolamide - timolol fixed dose bination ophthalmic solution. Many of these reactions had the clinical appearance and course of an allergic-type reaction that resolved upon discontinuation of drug therapy. If such reactions are observed, Dorzolamide-timolol fixed dose bination ophthalmic solution should be discontinued and the patient evaluated before considering restarting the drug. Therapy with oral carbonic anhydrase inhibitors has been associated with urolithiasis as a result of acid-base disturbances, especially in patients with a prior history of renal calculi. Although no acid-base disturbances have been observed with this medicinal product, urolithiasis has been reported infrequently. Because Dorzolamide-timolol fixed dose bination ophthalmic solution contains a topical carbonic anhydrase inhibitor that is absorbed systemically, patients with a prior history of renal calculi may be at increased risk of urolithiasis while using this medicinal product. The management of patients with acute angle-closure glaua requires therapeutic interventions in addition to ocular hypotensive agents.

Dorzolamide-timolol fixed dose bination ophthalmic solution has not been studied in patients with acute angle-closure glaua. Choroidal detachment after filtration procedures has been reported with the administration of aqueous suppressant therapy (e. g. timolol). Beta-adrenergic blockade has been reported to potentiate muscle weakness consistent with certain myasthenic symptoms (e. g. diplopia, ptosis and generalized weakness). Timolol has been reported, rarely, to increase muscle weakness in some patients with myasthenia gravis or myasthenic symptoms. As with the use of other antiglaua medicines, diminished responsiveness to ophthalmic timolol maleate after prolonged therapy has been reported in some patients. However, in clinical studies in which 164 patients have been followed for at least 3 years, no significant difference in mean intraocular pressure has been observed after initial stabilization. There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products.

These containers had been inadvertently contaminated by patients who, in most cases, had a concurrent corneal disease or a disruption of the ocular epithelial surface. Corneal oedema and irreversible corneal depensation have been reported in patients with pre-existing chronic corneal defects and/or a history of intraocular surgery while using dorzolamide. There is an increased potential for developing corneal oedema in patients with low endothelial cell counts topical dorzolamide - timolol fixed dose bination ophthalmic solution should be used with caution in such patients. Ophthalmic beta-blockers may induce dryness of eyes.

Patients with corneal diseases should be treated with caution. Patients should be advised that Dorzolamide-timolol fixed dose bination ophthalmic solution contains benzalkonium chloride, which may be absorbed by soft contact lenses. Contact lenses should be removed prior to administration of the solution. Lenses may be reinserted after 15 minutes following administration of Dorzolamide-timolol fixed dose bination ophthalmic solution. No studies on the effects on the ability to drive and use machines have been performed. Possible side effects such as blurred vision may affect some patients ability to drive and/or operate machinery. Systemic Exposure Dorzolamide-timolol fixed dose bination ophthalmic solution contains dorzolamide, a sulphonamide, and timolol maleate, a beta-adrenergic blocking agent and although administered topically, is absorbed systemically. Therefore, the same types of adverse reactions that are attributable to sulphonamides and/or systemic administration of beta-adrenergic blocking agents may occur with topical administration.

For example, severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and, rarely, death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol maleate. Fatalities have occurred, although rarely, due to severe reactions to sulphonamides, including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anaemia and other blood dyscrasias. Sensitization may recur when a sulphonamide is re-administered, irrespective of the route of administration. If signs of serious reactions or hypersensitivity occur, discontinue the use of this preparation. The following conitant medications are not remended: Dorzolamide and oral carbonic anhydrase inhibitors Use of two topical beta-adrenergic blocking agents Cardiac Failure Sympathetic stimulation may be essential for support of the circulation in individuals with diminished myocardial contractility, and its inhibition by beta-adrenergic receptor blockade may precipitate more severe failure. Because of the timolol maleate ponent, cardiac failure should be adequately controlled before beginning therapy with Dorzolamide-timolol fixed dose bination ophthalmic solution. Patients with a history of cardiovascular disease, including cardiac failure, should be watched for signs of deterioration of these diseases, and pulse rates should be checked.

Due to its negative effect on conduction time, beta-blockers should be given with caution to patients with first degree heart block. In patients without a history of cardiac failure continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. At the first sign or symptom of cardiac failure, Dorzolamide-timolol fixed dose bination ophthalmic solution should be discontinued. Obstructive Pulmonary Diseases Patients with chronic obstructive pulmonary disease (e. g. chronic bronchitis, emphysema) of mild or moderate severity, bronchospastic disease or a history of bronchospastic disease (other than bronchial asthma or a history of bronchial asthma, in which dorzolamide-timolol fixed dose bination ophthalmic solution is contraindicated, should, in general, not receive beta-blocking agents, including dorzolamide-timolol fixed dose bination ophthalmic solution. Major Surgery The necessity or desirability of withdrawal of beta-adrenergic blocking agents prior to major surgery is controversial. Beta-adrenergic receptor blockade impairs the ability of the heart to respond to beta-adrenergically mediated reflex stimuli. This may augment the risk of general anaesthesia in surgical procedures.

Some patients receiving beta-adrenergic receptor blocking agents have experienced protracted severe hypotension during anaesthesia. Difficulty in restarting and maintaining the heartbeat has also been reported. For these reasons, in patients undergoing elective surgery, some authorities remend gradual withdrawal of beta-adrenergic receptor blocking agents. If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists. Beta-blocking ophthalmological preparations may block systemic beta-agonist effects e. g. of adrenaline.

The anaesthesiologist should be informed when the patient is receiving timolol. Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycaemia or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycaemic agents. Beta-adrenergic receptor blocking agents may mask the signs and symptoms of acute hypoglycaemia. Thyrotoxicosis Beta-adrenergic blocking agents may mask certain clinical signs (e. g. tachycardia) of hyperthyroidism. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-adrenergic blocking agents that might precipitate a thyroid storm. Vascular Disorders Patients with severe peripheral circulatory disturbance/disorders (e. g. severe forms of Raynauds disease or Raynauds syndrome) should be treated with caution.

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