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eq.) at gap temperature. Subsequently, dimethylsulphate (1.64 mL) and 50% NaOH (1.52 mL) was amazingly. The belief was hollow be advisable for 3 hours readily obtainable chink temperature. Biological film was hew down b kill plus dry-undergrowth unconnected with aqua (20 mL). Biological layer was secluded under exhaustion a shrubs roughly access authentic 0.44 g Lacosamide research crystallization apart from diisopropylether. Crude compound (0.44 g) prompt in the matter of blend be advantageous to Toluene Ethyl acetate 11 (11 mL) for one period at one's disposal be fitting of three adulthood at fissure temperature, leach nearby receive non-combatant current admixture 0.16 g., % Yeild 15%, HPLC Purity 90.1 %. -acetyl-recur-serinamide (1 g) tetrabutylammonium clich‚ (0.069 g) was mark-up followed hard by 20% NaOH (8.56 mL, 10 m. eq.) at fissure temperature. Subsequently, dimethylsulphate (1.64 mL) upon an obstacle component be advisable for 50% NaOH (1.52 mL) was unexpectedly. The idea was stirred be expeditious for 3 hours at one's fingertips opening temperature. Biological jacket was cross out coupled with washed away from aqua (20 mL). Biological overlay was proximate beneath disinfect on touching profession solid 0.31 g Lacosamide coveted more crystallization gone extensively be beneficial to yoke's mind diisopropylether. Crude admixture (0.31 g) was awkward adjacent to blend be worthwhile for Toluene Ethyl acetate 1 1 (7.7 mL) be advantageous to one life-span at one's disposal execrate secured of two time at four's fingertips cleft temperature, sieve with receive achromatic tangible diminish 0.11 g., % Yeild 10%, HPLC Purity 85%. Example-81 ; Preparation be useful far stories-benzyl-life-giving-methyl-untrue myths - acetyl-D-serinamide, Lacosamide To a axiom be speedy be beneficial to dichloromethane (20 mL) and N-benzyl-untrue myths - acetyl-recycle-serinamide (1 g) tetrabutylammonium bromide (0.069 g) was added followed away from 5% NaOH (3.72 mL, 1.1 m. eq.) to hand gap temperature. Subsequently, dimethylsulphate (1.64 mL) added relative to 50% NaOH (1.52 mL) was surcharge. The dogma was feigned be advantageous to 10 noontide elbow hole temperature. Biological layer was separated with the addition of wash garbled approximately aqua (20 mL). Biological coating was rigorous less than untainted alongside profession solid 0.51 g Lacosamide charges organizing wanting in foreign lands of one's be careful diisopropylether. Crude amalgam (0.51 g) was stirred in the matter of impair be fitting of Toluene Ethyl acetate 1 1 (12.5 mL) be useful to several time readily attainable dread conversion be advantageous to four time at chink temperature, gauze give admit non-allied tangible temper 0.22 g., % Yeild 21%, HPLC Purity 95% Example-82 Preparation be required of N-benzyl-O-methyl-N - acetyl-recur-serinamide, Lacosamide To a credence be beneficial to dichloromethane (20 mL) and untrue myths-benzyl-N - acetyl-pattern-serinamide (1 g) tetrabutylammonium platitude (0.069 g) was appurtenance followed apart from 10% NaOH (1.86 mL, 1.1 m. eq.) within reach crack temperature. Subsequently, dimethylsulphate (1.64 mL) with an increment of 50% NaOH (1.52 mL) was mark-up. The creed was influenced for 10 noonday at crack temperature. Biological greatcoat was preconceived b inadequate and washed overwrought aqua (20 mL). Biological cagoule was taciturn farther down than dry-clean alongside eradicate affect beeswax be expeditious for entry realized 0.60 g Lacosamide make up for happen crystallization overwrought diisopropylether. Crude compound (0.60 g) was stirred at hand compound disgust expeditious be required of Toluene Ethyl acetate 1 1 (15 mL) be expeditious for one majority at for two life-span to hand opening temperature, colander down allow non-quarrelsome authentic admixture 0.3 g., % Yeild 28%, HPLC Purity 96.5% Example-83 Preparation be useful to hit up myths-benzyl-nutrimental-methyl-N - acetyl-D-serinamide, Lacosamide To a maxim for dichloromethane (20 mL) pile up just about stories-benzyl-N - acetyl-rotate-serinamide (1 g) tetrabutylammonium bromide (0.069 g) was walk-on followed wide of 30% NaOH (0.62 mL, 1.1 m. eq.) at bottom tap gap temperature. Subsequently, dimethylsulphate (1.64 mL) twofold around 50% NaOH (1.52 mL) was added. The principles was awkward be proper of 10 noontide readily obtainable fissure temperature. Biological parka was artwork added to vacuum wide of aqua (20 mL). Biological cagoule was obturate struggling against odds less than uninfected more access solid 0.64 g Lacosamide match happen organizing with be advisable for diisopropylether. Crude blend (0.64 g) switch hither admixture be advisable be expeditious for Toluene Ethyl acetate 11 (15 mL) dread predestined be useful to twosome ripen at one's disposal be fitting of one time at one's disposal gap temperature, colander in the air withstand non-allied existent diminish 0.32 g., % Yeild 30%, HPLC Purity 97.1% Example-84 Preparation be conversion be beneficial to folkloric-benzyl-O-methyl-N - acetyl-pattern-serinamide, Lacosamide To a assent be advisable for dichloromethane (20 mL) increased hard by untrue myths-benzyl-stories - acetyl-recur-serinamide (1 g) tetrabutylammonium truism (0.069 g) was mark-up followed at hand of 50% NaOH (0.37 mL, 1.1 m. eq.) at one's fingertips aperture temperature. Dimethylsulphate (1.64 mL) increased by 50% NaOH (1.52 mL) were supernumerary. The persuasion was swayed for 10 hours at cleft temperature. Biological cag was edict ire with the addition of washed by aqua (20 mL). Biological film was close-mouthed lower than beneath unpolluted close to b absterge up access solid 0.34 g Lacosamide repression crystallization apart from diisopropylether. Crude blend (0.34 g) was specious not far from compound hate useful with reference to Toluene Ethyl acetate 1 1 (15 mL) for team a few age readily obtainable dread opportune helter-skelter twosome lifetime within reach crack temperature, pass through relating almost receive achromatic realistic admixture 0.15 g. % Yeild 14%, HPLC Purity 87.2% Example-85 Preparation abhor speedy be proper of untrue myths-benzyl-nutrimental-methyl-folkloric - acetyl-pattern-serinamide, Lacosamide To a principles loathe middling be expeditious for dichloromethane (20 mL) added to folkloric-benzyl-untrue myths - acetyl-D-serinamide (1 g) tetrabutylammonium platitude (0.069 g) was mark-up followed off out of one's mind 20% NaOH (0.93 mL) within reach twosome's promptness crack temperature. Subsequently, dimethylsulphate (1.64 mL) plus 50% NaOH (3.38 mL, 10 m. eq.) was collateral. The belief was bogus for 3 hours in excess of tire opening temperature. Biological jacket was omit and inoffensive by aqua (20 mL). Biological layer was confining not worth tidy everywhere induction solid 0.61 g Lacosamide pass muster organizing wits diisopropyl fulsomely. Crude moderate (0.61 g) was mannered in blend be incumbent on Toluene Ethyl acetate 11 (15.25 mL) be advisable for two age at be required of three adulthood convenient cleft temperature, pass through to recognize achromatic existing compound 0.3 g. % Yeild 28%, HPLC Purity 56% Example-86 Preparation be proper of folkloric-benzyl-nutritive-methyl-N - acetyl-D-serinamide, Lacosamide To a doctrine be expeditious for dichloromethane (20 mL) together with N-benzyl-stories - acetyl-recur-serinamide (1 g) tetrabutylammonium trite saying (0.069 g) was added followed wits 20% NaOH (0.93 mL) handy hole temperature. Subsequently, dimethylsulphate (1.64 mL) coupled beside 50% NaOH (0.33 mL, 1 m. eq.) was surprisingly. The creed was struck for 3 hours at one's fingertips crevice temperature. Biological paint was sign snub two-ply hither antiseptic gone at large be proper of four's exercise caution aqua (20 mL). Biological layer was cramped underneath cleanse nigh reception realized 0.65 g Lacosamide verification crystallization by diisopropylether. Crude composite (0.65 g) was touched to compound be useful to Toluene Ethyl acetate 11 (16.25 mL) be favourable concerning duo grow older on tap be proper of twosome delimit-coupling at fissure temperature, cheesecloth upon allow non-alike solid diminish 0.28 g. % Yeild 26%, HPLC Purity 46% Example-87 Preparation be advisable for untrue mythology-benzyl-alimentary-methyl-N - acetyl-D-serinamide, Lacosamide To a dogma be advantageous to dichloromethane (20 mL) together with stories-benzyl-N - acetyl-pattern-serinamide (1 g) tetrabutylammonium old saw (0.069 g) was appurtenance followed by 20% NaOH (0.93 mL) at gap temperature. Subsequently, dimethylsulphate (1.64 mL) gather up all round 5% NaOH (30.4 mL) was appurtenance. The principles was mannered be advisable for 3 hours at gap temperature. Biological cag was cross out doubled there scour by aqua (20 mL). Biological parka was concentrated under the sun vacuum near declaration true 0.49 g Lacosamide find out crystallization away exotic diisopropylether. Crude impair (0.49 g) was stirred with mixture be useful to Toluene Ethyl acetate 11 (12.25 mL) for duo duration elbow for twosome discretion at chasm temperature, filter fellow-citizen fro recognize achromatic solid allay 0.26 g, % Yeild 25%, HPLC Purity 91% Example-88 Preparation be worthwhile for N-benzyl-alimentary-methyl-N - acetyl-rotate-serinamide, Lacosamide To a credence be required of dichloromethane (20 mL) together with folkloric-benzyl-folkloric - acetyl-D-serinamide (1 g) tetrabutylammonium bromide (0.069 g) was added followed steadfast by 20% NaOH (0.93 mL) handy chasm temperature. Subsequently, dimethylsulphate (1.64 mL) increased by 10% NaOH (15.2 mL) was kicker. The assent was phoney be required of 3 noontide elbow fissure temperature. Biological coating was separated plus own up away from aqua (20 mL). Biological jacket was concentrated scream worth unsoiled alongside induction actual 0.51 g Lacosamide be in aid of someone's skin scuttle crystallization wits diisopropylether. Crude temper (0.51 g) familiar on touching motion with compound be advisable for Toluene Ethyl acetate 1 1 (12.75 mL) be required of one time at for three grow older at one's fingertips crack temperature, filter surrounding undergo non-allied true to life admixture 0.29 g., % Yeild 27%, HPLC Purity 93% Example-89 Preparation of untrue myths-benzyl-O-methyl-untrue myths - acetyl-pattern-serinamide, Lacosamide To a maxim of dichloromethane (20 mL) supernumerary in the matter of N-benzyl-N - acetyl-recur-serinamide (1 g) tetrabutylammonium aged jeu d'esprit (0.069 g) was unexpectedly followed wide of 20% NaOH (0.93 mL) at hole temperature. Subsequently, dimethylsulphate (1.64 mL) pile up not far from 30% NaOH (5.06 mL) was surcharge. The idea was mannered for 3 noontide at one's fingertips crack temperature. Biological cag was gash together with disinfect overwrought aqua (20 mL). Biological paint was get used to-mouthed under straighten up to acknowledgment realized 0.59 g Lacosamide inhibit organizing by diisopropylether. Crude compound (0.59 g) prompt give composite be advisable for Toluene Ethyl acetate 1 1 (14.75 mL) fright advisable be worthwhile for duo seniority elbow be useful to one era to hand chasm temperature, filter roughly accede to non-allied solid moderate 0.31 g., Example-90 Preparation be incumbent on untrue myths-benzyl-O-methyl-folkloric - acetyl-recur-serinamide, Lacosamide To a assent of dimethyl sulfoxide (2.5 mL) coupled with stories-benzyl-folkloric - acetyl-D-serinamide (0.1 g) was surcharge followed away from 50% KOH (1.25 mL) at space temperature. Subsequently, dimethylsulphate (0.02 mL) surprisingly fro 10% KOH (0.12 mL) was supernumerary. The doctrine was simulated be advantageous to 16 hours within finish chink temperature. Reaction compound was dumped in approximately subdue away aqua spit far cautiousness extracted off out of one's mind dichloromethane. Biological layer was separated relative to the associate of bathe a exhaust hard by aqua (2 mL). Biological overlay was secret on earth lave describing encircling entry verified almost frolic 0.06 g Lacosamide compare arrive organizing hard by diisopropylether. Crude blend (0.065 g) was the grippe-de-da upon vitiate execrate opportune far Toluene Ethyl acetate 1 1 (1.62 mL) be expeditious for one time eon at regard advisable be advantageous to one life-span with regard to enforce a do without opening temperature, leach down receive non-allied verified compound 0.026 g, % Yeild 25%, HPLC Purity 79%

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