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by Ros Wood Danazol has been used to treat women with endometriosis since the 1970s 1. It was the most monly used drug in the early 1980s, but its use declined markedly after the introduction of the GnRH agonists in the late 1980s and early 1990s. Danazol is a synthetic androgen 1. Androgens are hormones produced by the male testes. They are responsible for the functioning of the male reproductive system and the development of the male characteristics, such as facial hair and a deep voice. The ovaries also produce small amounts of androgens. Danazol is an effective treatment for endometriosis, and has the same effectiveness as the other hormonal treatments. However, it has many androgenic (male-like) side effects, including weight gain, increased body hair and acne. Its unpleasant side effects and its tendency to adversely affect blood lipid (cholesterol) levels mean it is not usually the first choice of treatment for endometriosis 1. How it works Like all the other hormonal treatments, danazol does not cure endometriosis permanently. Rather, it suppresses its growth and development temporarily, so the disease may recur following treatment. Danazol has a multitude of effects on the body. Some of these effects bine to produce high levels of androgen and low levels of oestrogen in the body.
This hormonal environment stops menstruation and suppresses the growth of endometrial implants, causing them to degenerate 1,2. Most women will stop ovulating and menstruating by the second month of treatment, though this may depend on the dosage used. The symptoms of endometriosis usually begin to diminish by the end of the second month. Most women will resume ovulating and menstruating within 46 weeks of stopping treatment 2. The usual length of treatment is 36 months, but it may be extended to 9 months in some circumstances. The remended dosages vary.
North American gynaecologists tend to remend dosages of 800 milligrams per day, whereas European and Australian gynaecologists tend to remend dosages of 600 milligrams per day 3. Some gynaecologists believe it is better to base the dosage on the minimum needed to stop menstruation. In this case, they may suggest that you start with 400 milligrams per day, and, if necessary, increase the dose until your periods stop 3. Alternatively, they may suggest that you start with 600 milligrams a day, and reduce the dosage to 400 milligrams a day or even 200 milligrams a day 2. You should start your course of danazol on the first day of your period to decrease the risk of taking the drug while you are pregnant. If there is any possibility that you may be pregnant, you should have a pregnancy test before starting treatment 4. Although it is unlikely that you will conceive while on danazol, care should be taken to avoid pregnancy. It is remended that you use barrier contraception (condom or diaphragm or both) throughout treatment 4. You should not take danazol if you have 5: liver disease high blood pressure heart failure poor kidney functionDanazol is a synthetic steroid derived from ethisterone. It is a white to pale yellow crystalline powder, practically insoluble or insoluble in water, and sparingly soluble in alcohol. Chemically, Danazol is 17 - Pregna-2,4-dien-20-yno 2,3- d - isoxazol-17-ol. The molecular formula is C 22 H 27 NO 2 . It has a molecular weight of 337.46 and the following structural formula: Danazol capsules for oral administration contain 200160mg Danazol.
Inactive Ingredients: Corn Starch, Lactose, Magnesium Stearate, Talc, DampC Yellow 10, DampC Red 28, FDampC Red 40, Gelatin, Silicon Dioxide, Sodium Lauryl Sulfate, Titanium Dioxide. CLINICAL PHARMACOLOGY Danazol suppresses the pituitary-ovarian axis. This suppression is probably a bination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of Danazol with sex hormone receptors. The only other demonstrable hormonal effect is weak androgenic activity. Danazol depresses the output of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danazol to receptors of gonadal steroids at target organs. In addition, Danazol has been shown to significantly decrease IgG, IgM and IgA levels, as well as phospholipid and IgG isotope autoantibodies in patients with endometriosis and associated elevations of autoantibodies, suggesting this could be another mechanism by which it facilitates regression of the disease. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. When the dose of Danazol is doubled the increase in plasma levels is only about 35 to 40. Separate single dosing of 100 mg and 200 mg capsules of Danazol to female volunteers showed that both the extent of availability and the maximum plasma concentration increased by three-to-four fold, respectively, following a meal ( 30 grams of fat), when pared to the fasted state.
Further, food also delayed mean time to peak concentration of Danazol by about 30 minutes. In the treatment of endometriosis, Danazol alters the normal and ectopic endometrial tissue so that it bees inactive and atrophic. plete resolution of endometrial lesions occurs in the majority of cases. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis. In the treatment of fibrocystic breast disease, Danazol usually produces partial to plete disappearance of nodularity and plete relief of pain and tenderness. Changes in the menstrual pattern may occur.
Generally, the pituitary-suppressive action of Danazol is reversible. Ovulation and cyclic bleeding usually return within 60 to 90 days when therapy with Danazol is discontinued. In the treatment of hereditary angioedema, Danazol at effective doses prevents attacks of the disease characterized by episodic edema of the abdominal viscera, extremities, face, and airway which may be disabling and, if the airway is involved, fatal. In addition, Danazol corrects partially or pletely the primary biochemical abnormality of hereditary angioedema by increasing the levels of the deficient C1 esterase inhibitor (C1EI). As a result of this action the serum levels of the C4 ponent of the plement system are also increased. INDICATIONS AND USAGE Endometriosis. Danazol is indicated for the treatment of endometriosis amenable to hormonal management.
Fibrocystic Breast Disease. Most cases of symptomatic fibrocystic breast disease may be treated by simple measures (e. g. padded brassieres and analgesics). In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danazol is usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very mon after cessation of therapy. Hereditary Angioedema. Danazol is indicated for the prevention of attacks of angioedema of all types (cutaneous, abdominal, laryngeal) in males and females. Danazol should not be administered to patients with:What Is Danazol Danazol is a man-made form of a steroid.
Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder (hereditary angioedema). Danazol may also be used for purposes not listed in this medication guide. You should not use this medication if you are allergic to danazol, or if you have porphyria, a history of stroke or blood clot, or severe problems with your heart, liver, or kidney. You also should not take danazol if you are pregnant or breast-feeding, if you have breast or uterine cancer, or if you have abnormal vaginal bleeding that has not been checked by a doctor.
Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use a barrier form of birth control (such as a condom or diaphragm with spermicide).
Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment with danazol. Your medication needs may change if you bee ill, have a fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you. Do not change your medication dose or schedule without your doctor39s advice. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment. Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes). You should not use this medication if you are allergic to danazol, or if you have: severe heart disease, a history of stroke or blood clot severe kidney disease severe liver disease a hormone-related cancer such as breast or uterine cancer porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system) abnormal vaginal bleeding that has not been checked by a doctor or if you are pregnant or breast-feeding.
To make sure you can safely take danazol, tell your doctor if you have any of these other conditions: heart disease, high blood pressure, coronary artery disease, congestive heart failure high cholesterol or triglycerides a history of breast cancer diabetes hypoparathyroidism, or low levels of calcium in your blood a seizure disorder kidney or liver disease or migraine headaches. FDA pregnancy category X. This medication can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use danazol if you are pregnant. Stop taking danazol and tell your doctor right away if you bee pregnant during treatment.
You may need to have a negative pregnancy test before starting this treatment. Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment with danazol. Danazol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using danazol. Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk.
Danazol Side Effects Get emergency medical help if you have any of these signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat. In rare cases, danazol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Call your doctor at once if you have a serious side effect such as: sudden numbness or weakness (especially on one side of the body), confusion, problems with speech or balance severe headache, ringing in your ears, dizziness, nausea, vomiting, vision problems, pain behind your eyes chest pain, sudden cough, wheezing, rapid breathing, coughing up blood pain, swelling, warmth, or redness in one or both legs swelling or rapid weight gain, especially in your face and midsection bloody, black, or tarry stools cough up blood or vomit that looks like coffee grounds or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include: acne or other skin problems, increased sweating increased hair growth or hair loss breast changes decreased amount of semen released during sex hoarse or deepened voice, sore throat flushing (warmth, redness, or tingly feeling) changes in your menstrual periods unusual vaginal bleeding or spotting vaginal dryness, disfort, or itching. This is not a plete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Danazol Description Danazol USP is a synthetic steroid derived from ethisterone. It is a white to pale yellow crystalline powder, practically insoluble or insoluble in water, and sparingly soluble in alcohol. Chemically, Danazol USP is 17alpha-Pregna-2,4-dien-20-yno 2,3- d - isoxazol-17-ol, which has the following structural formula: Slideshow: Parkinsons Disease: A Healthcare Professionals Guide C 22 H 27 NO 2 M. W. 337.46 Danazol capsules USP for oral administration, contain 50 mg, 100 mg or 200 mg of Danazol USP. In addition, each capsule contains the following inactive ingredients: black iron oxide, DampC yellow no. 10, DampC yellow no. 10 aluminum lake, FDampC blue no. 1 aluminum lake, FDampC blue no. 2 aluminum lake, FDampC red no. 40 aluminum lake, gelatin, lactose monohydrate, magnesium stearate, pharmaceutical glaze, propylene glycol, sodium starch glycolate, stearic acid and titanium dioxide The 50 mg and 100 mg capsule shells also contain FDampC yellow no. 6. The 200 mg capsule shell also contains FDampC red no. 40 and DampC red no. 28. Danazol - Clinical Pharmacology Danazol suppresses the pituitary-ovarian axis.
This suppression is probably a bination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of Danazol with sex hormone receptors. The only other demonstrable hormonal effect is weak androgenic activity. Danazol depresses the output of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danazol to receptors of gonadal steroids at target organs. In addition, Danazol has been shown to significantly decrease IgG, IgM and IgA levels, as well as phospholipid and IgG isotope autoantibodies in patients with endometriosis and associated elevations of autoantibodies, suggesting this could be another mechanism by which it facilitates regression of the disease. In the treatment of endometriosis, Danazol alters the normal and ectopic endometrial tissue so that it bees inactive and atrophic. plete resolution of endometrial lesions occurs in the majority of cases. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis.
In the treatment of fibrocystic breast disease, Danazol usually produces partial to plete disappearance of nodularity and plete relief of pain and tenderness. Changes in the menstrual pattern may occur. Generally, the pituitary-suppressive action of Danazol is reversible. Ovulation and cyclic bleeding usually return within 60 to 90 days when therapy with Danazol is discontinued. In the treatment of hereditary angioedema, Danazol at effective doses prevents attacks of the disease characterized by episodic edema of the abdominal viscera, extremities, face, and airway which may be disabling and, if the airway is involved, fatal.
In addition, Danazol corrects partially or pletely the primary biochemical abnormality of hereditary angioedema by increasing the levels of the deficient C1 esterase inhibitor (C1EI). As a result of this action the serum levels of the C4 ponent of the plement system are also increased. Pharmacokinetics Absorption: After oral administration of a 400 mg dose to healthy male volunteers, peak plasma concentrations of Danazol are reached between 2 and 8 hours, with a median T max value of 4 hours. Steady state conditions are observed following 6 days of twice daily dosing of Danazol. The pharmacokinetic parameters for Danazol after administering a 400 mg oral dose to healthy males are summarized in the following table:/media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-patientcare. jpg / Quality Care Find out why Mayo Clinic is the right place for your health care. Make an appointment. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-docsdepts. jpg / Meet the Staff Find a directory of doctors and departments at all Mayo Clinic campuses.
Visit now. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-research. jpg / Research and Clinical Trials See how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care. Explore now. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-meded. jpg / Visit Our Schools Educators at Mayo Clinic train tomorrows leaders to deliver passionate, high-value, safe patient care. Choose a degree. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-medprofs.
jpg / Professional Services Explore Mayo Clinics many resources and see jobs available for medical professionals. Get updates. /media/kcms/gbs/research/images/2014/04/29/12/35/globalnav-you-are-blue. jpg / Give to Mayo Clinic Help set a new world standard in care for people everywhere. Give now. On this page Start taking danazol on the first day of your period unless you have been told otherwise.
You can take the capsules either before or after meals. About danazol Available as Danazol works by altering the levels of some of your bodys hormones. It is used to treat a number of different conditions. Endometriosis is a condition where tissue that normally lines the inside of your womb (uterus) is found elsewhere in your body, often in the pelvic area or abdomen.
It can cause painful periods and persistent pain in the pelvic area, as well as other symptoms. By altering the levels of your hormones, danazol will help to relieve these symptoms. Danazol is also prescribed to ease severe pain and tenderness associated with breast cyst disease (where other treatments have proved unhelpful). Breast cysts are small lumps which are found in the breast, but which are not cancerous. In addition to the two conditions above, danazol is also prescribed by specialist doctors for people with a condition known as hereditary angio-oedema (although it is not licensed for this condition).
If you have been prescribed it for this reason, please speak with your doctor if you have any questions about your treatment. Related discussionsDanazol 50 mg-BAR What are the possible side effects of danazol (Danocrine) Get emergency medical help if you have any of these signs of an allergic reaction . hives difficult breathing swelling of your face, lips, tongue, or throat. In rare cases, danazol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever. unusual tiredness, and dark colored urine. Call your doctor at once if you have a serious side effect such as: sudden numbness or weakness (especially on one side of the body), confusion, problems with speech or balance severe headache. ringing in your ears, dizziness.
nausea, vomiting, vision problems, pain behind your eyes chest pain. sudden cough. wheezing, rapid breathing, coughing up blood pain, swelling, warmth, or redness in one or both legs swelling or rapid weight gain, especially in your face and midsection bloody, black, or tarry stools cough up blood or vomit that looks like coffee grounds or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious side effects may include: acne or other skin problems, increased sweating increased hair growth or hair loss breast changes decreased amount of semen released during sex hoarse or deepened voice, sore throat flushing (warmth, redness, or tingly feeling) changes in your menstrual periods unusual vaginal bleeding or spotting vaginal dryness, disfort, or itching.
This is not a plete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about danazol (Danocrine) You should not use this medication if you are allergic to danazol, or if you have porphyria, a history of stroke or blood clot, or severe problems with your heart, liver, or kidney.
You also should not take danazol if you are pregnant or breast-feeding, if you have breast or uterine cancer, or if you have abnormal vaginal bleeding that has not been checked by a doctor. Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment with danazol.
Your medication needs may change if you bee ill, have a fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you. Do not change your medication dose or schedule without your doctors advice. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment. Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).Endometriosis Mild: 200-400 mg/day PO divided BID Moderate-to-severe: 800 mg/day PO divided BID Titrate downward to dose sufficient to maintain amenorrhea Fibrocystic Breast Disease 100-400 mg/day PO divided BID Frequency Not Defined Increased blood pressure Thromboembolism Depression Black Box Warnings Pregnancy amp Lactation Pregnancy Category: X Lactation: enters breast milk/contraindicated Pregnancy Categories A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk. B: May be acceptable.
Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.
Danazol Reviews Discussions danazol. Finally got the danazol. The pharmacy had to order it, which took a few extra days, so I just now took my first pill. Ill let u all know if anything. More danazol.
Thanks for the link. The more I read on it, the more it worries me that Ill turn into a deep voiced hairy beast. But I just feel like Im not going. More danazol. Its supposed to slow the estrogen down so it starves the endo growths and possibly shrinks them. But there are some ugly side effects. voice deepeni. More danazol.
I have not heard of it. What is it What does it do More Danazol If you are TTC, you cannot try for 6 months following Danazol. Natural progesterone is the only treatment that worked for me without the side effect. MoreDanazol Side Effects Last Updated: May 18, 2010 By Carole Anne Tomlinson Carole Anne Tomlinson Carole Anne Tomlinson is a registered nurse with experience in rehabilitation, nutrition, chemical dependency, diabetes and health problems related to the elderly. Tomlinson holds a Bachelor of Arts in criminal justice and is presently working on her masters degree in nursing. Her screenplays have been viewed by Merchant Ivory, Angela Lansbury and Steven Kings associates. The synthetic steroid generically named danazol may be prescribed for a variety of uses, the Mayo Clinic reports, that generally relate to sexual development and ailments. For example, danazol may be prescribed to reduce the pain of endometriosis, a scarring disease of the uterus, as well as to help overe fertility problems caused by this disease. The medicine also may help fight fibrocystic breast disease, premature development of girls and gyneastia, a condition in men in which their breasts develop more than normal. Breast and Weight Side Effects In women, danazol may induce problems that potentially are serious mon side effects relating to their breasts and weight.
The medication may reduce the size of womens breasts. Danazol also may induce the unintended gaining of weight. These side effects, the Mayo Clinic states, require medical attention as soon as possible. Menstrual Problems Danazol also can work to decrease the disfort of menstrual pain, but it also may induce a mon serious side effect in women that affects their menstruation. The use of the medicine may cause a disruption in cycles for the woman, meaning she may experience an irregularity of her periods, the Mayo Clinic reports. This, too, classifies as a serious medical problem requiring professional help./media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-patientcare.
jpg / Quality Care Find out why Mayo Clinic is the right place for your health care. Make an appointment. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-docsdepts. jpg / Meet the Staff Find a directory of doctors and departments at all Mayo Clinic campuses. Visit now. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-research. jpg / Research and Clinical Trials See how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care.
Explore now. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-meded. jpg / Visit Our Schools Educators at Mayo Clinic train tomorrows leaders to deliver passionate, high-value, safe patient care. Choose a degree. /media/kcms/gbs/research/images/2013/05/02/10/56/globalnav-medprofs. jpg / Professional Services Explore Mayo Clinics many resources and see jobs available for medical professionals. Get updates. /media/kcms/gbs/research/images/2014/04/29/12/35/globalnav-you-are-blue. jpg / Give to Mayo Clinic Help set a new world standard in care for people everywhere. Give now. Danazol 50 mg-BAR What is the most important information I should know about danazol You should not use this medication if you are allergic to danazol, or if you have porphyria, a history of stroke or blood clot, or severe problems with your heart, liver, or kidney.
You also should not take danazol if you are pregnant or breast-feeding, if you have breast or uterine cancer, or if you have abnormal vaginal bleeding that has not been checked by a doctor. Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use a barrier form of birth control (such as a condom or diaphragm with spermicide).
Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment with danazol. Your medication needs may change if you bee ill, have a fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you. Do not change your medication dose or schedule without your doctors advice. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment. Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes). What is danazol Danazol is a man-made form of a steroid.
Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder (hereditary angioedema). Danazol may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking danazol You should not use this medication if you are allergic to danazol, or if you have: severe heart disease, a history of stroke or blood clot severe kidney disease severe liver disease a hormone-related cancer such as breast or uterine cancer porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system) abnormal vaginal bleeding that has not been checked by a doctor or if you are pregnant or breast-feeding. To make sure you can safely take danazol, tell your doctor if you have any of these other conditions: heart disease, high blood pressure, coronary artery disease, congestive heart failure high cholesterol or triglycerides a history of breast cancer diabetes hypoparathyroidism, or low levels of calcium in your blood a seizure disorder kidney or liver disease or migraine headaches. FDA pregnancy category X. This medication can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use danazol if you are pregnant.
Stop taking danazol and tell your doctor right away if you bee pregnant during treatment. You may need to have a negative pregnancy test before starting this treatment. Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment with danazol. Danazol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using danazol.
Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. How should I take danazol Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than remended. Follow the directions on your prescription label. Women who take danazol to treat endometriosis or fibrocystic breast disease should start the medication during a menstrual period. Danazol is usually given for 6 to 9 months to treat fibrocystic breast disease or endometriosis. To prevent attacks of hereditary angioedema, you may need to use the medication long-term. Follow your doctors instructions.
Your doctor may occasionally change your dose to make sure you get the best results. Your medication needs may change if you bee ill, have a fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you. Do not change your medication dose or schedule without your doctors advice. Use danazol regularly to get the most benefit.
Try not to miss any doses. Get your prescription refilled before you run out of medicine pletely. While using danazol, you may need blood tests at your doctors office. Visit your doctor regularly. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment.
What happens if I miss a doseDanazol News ADVERSE REACTIONS The following events have been reported in association with the use of danazol: Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with danazol, persistent amenorrhea has occasionally been reported. Flushing, sweating, vaginal dryness and irritation and reduction in breast size, may reflect lowering of estrogen. Nervousness and emotional lability have been reported.
In the male a modest reduction in spermatogenesis may be evident during treatment. Abnormalities in semen volume, viscosity, sperm count, and motility may occur in patients receiving long-term therapy. Hepatic dysfunction, as evidenced by reversible elevated serum enzymes and/or jaundice, has been reported in patients receiving a daily dosage of danazol of 400 mg or more. It is remended that patients receiving danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation. Serious hepatic toxicity including cholestatic jaundice, peliosis hepatis, and hepatic adenoma have been reported (see WARNINGS and PRECAUTIONS ). Abnormalities in laboratory tests may occur during therapy with danazol including CPK, glucose tolerance, glucagon, thyroid binding globulin, sex hormone binding globulin, other plasma proteins, lipids and lipoproteins.
The following reactions have been reported, a causal relationship to the administration of danazol has neither been confirmed nor refuted allergic: urticaria, pruritus and rarely, nasal congestion CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis and splenic peliosis musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention genitourinary: hematuria, prolonged posttherapy amenorrhea hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes (maculopapular, vesicular, papular, purpuric, petechial), and rarely, sun sensitivity, Stevens-Johnson syndrome and erythema multiforme other: increased insulin requirements in diabetic patients, change in libido, myocardial infarction, palpitation, tachycardia, elevation in blood pressure, interstitial pneumonitis, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use. REPORTS OF SUSPECTED DANAZOL SIDE EFFECTS / ADVERSE REACTIONS Possible Danazol side effects / adverse reactions in 72 year old female Reported by a health professional (non-physician/pharmacist) from Ireland on 2011-11-04 Other drugs received by patient: Perindopril Erbumine Levothyroxine Sodium Possible Danazol side effects / adverse reactions in 47 year old female Reported by a physician from Switzerland on 2011-11-29 Patient: 47 year old female Reactions: Hepatocellular Injury Other drugs received by patient: Tramadol Hydrochloride ALL Other Therapeutic Products Calcimagon Fosamax Livial Possible Danazol side effects / adverse reactions in 91 year old maleDanazol 50 mg-BAR What is the most important information I should know about danazol You should not use this medication if you are allergic to danazol, or if you have porphyria, a history of stroke or blood clot, or severe problems with your heart, liver, or kidney. You also should not take danazol if you are pregnant or breast-feeding, if you have breast or uterine cancer, or if you have abnormal vaginal bleeding that has not been checked by a doctor. Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant. You may need to have a negative pregnancy test before starting this treatment.
Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment with danazol. Your medication needs may change if you bee ill, have a fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you. Do not change your medication dose or schedule without your doctors advice. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment. Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes). What is danazol Danazol is a man-made form of a steroid.
Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder (hereditary angioedema). Danazol may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking danazol You should not use this medication if you are allergic to danazol, or if you have: severe heart disease, a history of stroke or blood clot severe kidney disease severe liver disease a hormone-related cancer such as breast or uterine cancer porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system) abnormal vaginal bleeding that has not been checked by a doctor or if you are pregnant or breast-feeding. To make sure you can safely take danazol, tell your doctor if you have any of these other conditions: heart disease, high blood pressure, coronary artery disease, congestive heart failure high cholesterol or triglycerides a history of breast cancer diabetes hypoparathyroidism, or low levels of calcium in your blood a seizure disorder kidney or liver disease or migraine headaches. FDA pregnancy category X. This medication can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use danazol if you are pregnant. Stop taking danazol and tell your doctor right away if you bee pregnant during treatment.
You may need to have a negative pregnancy test before starting this treatment. Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment with danazol. Danazol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using danazol. Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. How should I take danazol Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than remended.
Follow the directions on your prescription label. Women who take danazol to treat endometriosis or fibrocystic breast disease should start the medication during a menstrual period. Danazol is usually given for 6 to 9 months to treat fibrocystic breast disease or endometriosis. To prevent attacks of hereditary angioedema, you may need to use the medication long-term. Follow your doctors instructions. Your doctor may occasionally change your dose to make sure you get the best results.
Your medication needs may change if you bee ill, have a fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you. Do not change your medication dose or schedule without your doctors advice. Use danazol regularly to get the most benefit. Try not to miss any doses. Get your prescription refilled before you run out of medicine pletely. While using danazol, you may need blood tests at your doctors office. Visit your doctor regularly. It may take several weeks before your symptoms improve.
Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment. This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using danazol. What happens if I miss a doseBOSTON, MA -- November 5, 2007 -- Patients receiving the standard treatment of pegylated interferon alfa 2a plus ribavirin for chronic hepatitis C virus (HCV) may bee thrombocytopenic, but are able to achieve increased platelet counts through danazol therapy, according to research presented here at the 58th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). This is the first report of using a novel alternative treatment for thrombocytopenia in this difficult patient population, noted lead author, Guillermo Cabrera-Alvarez, MD, Gastroenterology and Liver Department, Internal Medicine Division, Regional General Hospital - Family Medicine Unit 1, Mexican Social Security Institute, Cuernavaca, Morelos, Mexico.
Dr. Cabrera-Alvarez and colleagues conducted an open-label clinical trial of 41 danazol-naive patients with chronic HCV (90 with cirrhosis of the liver), who had developed thrombocytopenia as a result of treatment with pegylated interferon alga 2a plus ribavirin. The treatment group (n 26, 20 female) received danazol at 300-600 mg/day until the end of the HCV therapy. Fifteen control subjects (9 females) were matched for baseline platelet count, presence of cirrhosis, age, sex, and HCV genotype, but were not considered thrombocytopenic. The mean baseline platelet count for treated patients was 75,300 177 11,502, which was increased at the end of the study to 123,900 177 30,411 (P .0063) in the 23 patients available for evaluation (20 females).
Of those 23 danazol-treated patients, 4 were considered non-responders, 7 were mild responders, and 12 were considered to have had a good response. Efficacy was evaluated as the capacity to increase platelet counts until the end of the treatment period. In the control group (non-thrombocytopenic), the mean platelet count went from 238,953.3 177 141,962.9 at baseline to 174,200 177 91,643 at end of treatment (P .9246). Only two danazol-treated patients developed reversible cholestasis, noted Dr. Cabrera-Alvarez. No other patients presented with side effects. We believe that maybe the mechanism of action involves impairment of macrophage-mediated clearance of antibody-coated platelets via decreased Fc receptor expression, as in autoimmune thrombocytopenia, said Dr. Cabrera-Alvarez. Danazol has been used successfully to treat patients with autoimmune thrombocytopenia. Danazol is a derivative of the synthetic steroid ethisterone, a modified testoterone. This drug decreases the follicle-stimulating hormone and luteinizing hormone.
Liver function must be monitored on a periodic basis in patients receiving long-term therapy with danazol, as it is metabolised by the liver. Presentation title: Danazol Increases the Platelets Count in Thrombo-Cytopenic Patients with Chronic Hepatitis C and Liver Cirrhosis Treated With Peg-Interferon Alfa 2a and Ribavirin. Abstract 260 Danazol Increases the Platelets Count in Thrombo-Cytopenic Patients with Chronic Hepatitis C and Liver Cirrhosis Treated With Peg-Interferon Alfa 2a and Ribavirin. G. Cabrera-Alvarez1 L. Canedo-Dorantes2 J. Reyes-Esparza3 L. Rodriguez-Fragoso3 N. Mendez-Sanchez5 A. Burguete4 V. Madrid-Marina4 1. Gastroenterology, IMSS, Cuernavaca, Morelos, Mexico. 2. Faculty of Medicine, Postgraduate Division, Universidad Autnoma del Estado de Morelos, Cuernavaca, Morelos, Morelos, Mexico. 3. Faculty of Pharmacology, Universidad Autnoma del Estado de Morelos, Cuernavaca, Morelos, Morelos, Mexico.
4. Chronic Infections and Cancer Division, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Morelos, Mexico. 5. Liver Unit, Medica Sur Clinic Foundation, Mexico city, Mxico, Mexico. Background and Aim: Chronic hepatitis C (HCV) infection has been associated with the development of several extrahepatic alterations, including thrombocytopenia. Currently it remains unresolved. Danazol, an attenuated androgen has been succesfully used in patients with autoimmune thrombocytopenia. The aim of the present study was to investigate the effects of Danazol treatment for thrombocytopenia associated to peginterferon alfa-2a and ribavirin therapy in naive HCV patients. Methods: A prospective study carried out in patients with chronic hepatitis C or liver cirrhosis patients who were under antiviral therapy. The protocol was approved by the Review Board/Ethics mittee of the Hospital.
The inclusion criteria including both gender, age (20 to 70 yr), without co-infection with hepatitis B virus or human immunodeficiency virus (HIV-1/2), thrombocytopenia during peginterferon alfa-2a and ribavirin therapy was defined when the count was 8806 90,000 platelets/mL in the last month. Danazol 300-600 mg/day was administered until the end of therapy. We considere as a control patients those on antiviral therapy who did not receive adjuvant danazol due to only mild thrombocytopenia on antiviral therapy, matched for baseline platelet count, presence of cirrhosis, age, sex and HCV genotype. Efficacy was evaluated as the capacity to increase in platelet counts until the end of the treatment period.
Results: A total of 41 patients with HCV-associated thrombocytopenia with PEG IFN/ribavirin treatment were studied: 26 patients (20 females, 6 males), mean age of 54.57177 8.40 yr who received danazol and 15 controls (9 females, 6 males), mean age of 55.8 177 13 yr. Ninety percent of 41 patients had cirrhosis and the HCV genotypes were similar between groups. The platelet count increases in the Danazol group from baseline (75300 177 11502) after treatment (123,900 177 30411 p0.0063). Whereas in the control group the mean count range from (238953.3 177 141962.9 to 174200177 91643, p0.9246) respectively. No association between genotypes and thrombocytopenia was observed (P0.05). Danazol safety was assessed by the absence of collateral negative effects, except colestasis reversible in two patients.
Conclusions: Adjuvant use of Danazol is associated with increased platelets counts in patients on antiviral therapy with interferon and rivabirin for HCV infection and cirrhosis. This is new therapeutic option to treat thrombocytopenia and maximize the sustained virologic responseDiscussion on Testosterone Replacement Therapy Something New: Danazol When speaking with Chip on today I learned about Danazol. thought Id share and hope Chip doesnt mind. if you do, sorry Chip Danazol, is a replacement for oxandrolone amp stanozolol Suggested dose protocol: Take one 25mg capsule twice per day for 30 days then once per day thereafter to maintain. For extreme cases of sexual dysfunction (God help you. )- take 3 25mg capsule per day for 90 days then 25mg per day thereafter to maintain. Danazol is also an quotanti-estrogenquot which can assist in blocking testosterones conversion to estradiol. Any of you guys heard of it Sounds interesting to me.
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